FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220758381> ?p ?o ?g. }

• W4220758381 endingPage "2893" @default.
• W4220758381 startingPage "2882" @default.
• W4220758381 abstract "A significant proportion of patients with short-lasting unilateral neuralgiform headache attacks are refractory to medical treatments. Neuroimaging studies have suggested a role for ipsilateral trigeminal neurovascular conflict with morphological changes in the pathophysiology of this disorder. We present the outcome of an uncontrolled open-label prospective single-centre study conducted between 2012 and 2020, to evaluate the efficacy and safety of trigeminal microvascular decompression in refractory chronic short-lasting unilateral neuralgiform headache attacks with MRI evidence of trigeminal neurovascular conflict ipsilateral to the pain side. Primary endpoint was the proportion of patients who achieved an 'excellent response', defined as 90-100% weekly reduction in attack frequency, or 'good response', defined as a reduction in weekly headache attack frequency between 75% and 89% at final follow-up, compared to baseline. These patients were defined as responders. The study group consisted of 47 patients, of whom 31 had short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, and 16 had short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (25 females, mean age ± SD 55.2 years ± 14.8). Participants failed to respond or tolerate a mean of 8.1 (±2.7) preventive treatments pre-surgery. MRI of the trigeminal nerves (n = 47 patients, n = 50 symptomatic trigeminal nerves) demonstrated ipsilateral neurovascular conflict with morphological changes in 39/50 (78.0%) symptomatic nerves and without morphological changes in 11/50 (22.0%) symptomatic nerves. Postoperatively, 37/47 (78.7%) patients obtained either an excellent or a good response. Ten patients (21.3%, short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing = 7 and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms = 3) reported no postoperative improvement. The mean post-surgery follow-up was 57.4 ± 24.3 months (range 11-96 months). At final follow-up, 31 patients (66.0%) were excellent/good responders. Six patients experienced a recurrence of headache symptoms. There was no statistically significant difference between short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks in the response to surgery (P = 0.463). Responders at the last follow-up were, however, more likely to not have interictal pain (77.42% versus 22.58%, P = 0.021) and to show morphological changes on the MRI (78.38% versus 21.62%, P = 0.001). The latter outcome was confirmed in the Kaplan-Meyer analysis, where patients with no morphological changes were more likely to relapse overtime compared to those with morphological changes (P = 0.0001). All but one patient, who obtained an excellent response without relapse, discontinued their preventive medications. Twenty-two post-surgery adverse events occurred in 18 patients (46.8%) but no mortality or severe neurological deficit was seen. Trigeminal microvascular decompression may be a safe and effective long-term treatment for patients suffering short-lasting unilateral neuralgiform headache attacks with MRI evidence of neurovascular conflict with morphological changes." @default.
• W4220758381 created "2022-04-03" @default.
• W4220758381 creator A5016058429 @default.
• W4220758381 creator A5022140806 @default.
• W4220758381 creator A5023034194 @default.
• W4220758381 creator A5036767918 @default.
• W4220758381 creator A5054698002 @default.
• W4220758381 creator A5064259046 @default.
• W4220758381 creator A5065076505 @default.
• W4220758381 creator A5069926672 @default.
• W4220758381 creator A5088463655 @default.
• W4220758381 date "2022-03-23" @default.
• W4220758381 modified "2023-09-26" @default.
• W4220758381 title "Trigeminal microvascular decompression for short-lasting unilateral neuralgiform headache attacks" @default.
• W4220758381 cites W11563888 @default.
• W4220758381 cites W1596353656 @default.
• W4220758381 cites W1817733919 @default.
• W4220758381 cites W1965563178 @default.
• W4220758381 cites W1982272694 @default.
• W4220758381 cites W1983669801 @default.
• W4220758381 cites W1996897475 @default.
• W4220758381 cites W2014501747 @default.
• W4220758381 cites W2017268752 @default.
• W4220758381 cites W2051812095 @default.
• W4220758381 cites W2064170874 @default.
• W4220758381 cites W2076608564 @default.
• W4220758381 cites W2077270511 @default.
• W4220758381 cites W2085418440 @default.
• W4220758381 cites W2095922755 @default.
• W4220758381 cites W2103788878 @default.
• W4220758381 cites W2107801660 @default.
• W4220758381 cites W2108608733 @default.
• W4220758381 cites W2111329718 @default.
• W4220758381 cites W2113442092 @default.
• W4220758381 cites W2117753124 @default.
• W4220758381 cites W2137566510 @default.
• W4220758381 cites W2144011294 @default.
• W4220758381 cites W2148144077 @default.
• W4220758381 cites W2155221506 @default.
• W4220758381 cites W2313494828 @default.
• W4220758381 cites W2321711807 @default.
• W4220758381 cites W2345388706 @default.
• W4220758381 cites W2511833556 @default.
• W4220758381 cites W2640885106 @default.
• W4220758381 cites W2762529100 @default.
• W4220758381 cites W2766216187 @default.
• W4220758381 cites W2769724041 @default.
• W4220758381 cites W2793051137 @default.
• W4220758381 cites W2800223298 @default.
• W4220758381 cites W2801085490 @default.
• W4220758381 cites W2922242162 @default.
• W4220758381 cites W2944407352 @default.
• W4220758381 cites W2969242314 @default.
• W4220758381 cites W3049171345 @default.
• W4220758381 cites W3111917836 @default.
• W4220758381 cites W3116233806 @default.
• W4220758381 cites W4248075514 @default.
• W4220758381 cites W4362216782 @default.
• W4220758381 doi "https://doi.org/10.1093/brain/awac109" @default.
• W4220758381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35325067" @default.
• W4220758381 hasPublicationYear "2022" @default.
• W4220758381 type Work @default.
• W4220758381 citedByCount "7" @default.
• W4220758381 countsByYear W42207583812022 @default.
• W4220758381 countsByYear W42207583812023 @default.
• W4220758381 crossrefType "journal-article" @default.
• W4220758381 hasAuthorship W4220758381A5016058429 @default.
• W4220758381 hasAuthorship W4220758381A5022140806 @default.
• W4220758381 hasAuthorship W4220758381A5023034194 @default.
• W4220758381 hasAuthorship W4220758381A5036767918 @default.
• W4220758381 hasAuthorship W4220758381A5054698002 @default.
• W4220758381 hasAuthorship W4220758381A5064259046 @default.
• W4220758381 hasAuthorship W4220758381A5065076505 @default.
• W4220758381 hasAuthorship W4220758381A5069926672 @default.
• W4220758381 hasAuthorship W4220758381A5088463655 @default.
• W4220758381 hasBestOaLocation W42207583811 @default.
• W4220758381 hasConcept C105572291 @default.
• W4220758381 hasConcept C121332964 @default.
• W4220758381 hasConcept C141071460 @default.
• W4220758381 hasConcept C142424586 @default.
• W4220758381 hasConcept C2777397368 @default.
• W4220758381 hasConcept C2780355897 @default.
• W4220758381 hasConcept C2780504541 @default.
• W4220758381 hasConcept C42219234 @default.
• W4220758381 hasConcept C71924100 @default.
• W4220758381 hasConcept C87355193 @default.
• W4220758381 hasConceptScore W4220758381C105572291 @default.
• W4220758381 hasConceptScore W4220758381C121332964 @default.
• W4220758381 hasConceptScore W4220758381C141071460 @default.
• W4220758381 hasConceptScore W4220758381C142424586 @default.
• W4220758381 hasConceptScore W4220758381C2777397368 @default.
• W4220758381 hasConceptScore W4220758381C2780355897 @default.
• W4220758381 hasConceptScore W4220758381C2780504541 @default.
• W4220758381 hasConceptScore W4220758381C42219234 @default.
• W4220758381 hasConceptScore W4220758381C71924100 @default.
• W4220758381 hasConceptScore W4220758381C87355193 @default.
• W4220758381 hasFunder F4320315071 @default.
• W4220758381 hasFunder F4320319990 @default.

• next