FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220761323> ?p ?o ?g. }

• W4220761323 endingPage "17" @default.
• W4220761323 startingPage "1" @default.
• W4220761323 abstract "#Background. Because of the heterogeneity of hepatocellular carcinoma (HCC) and the complex nature of the tumor microenvironment (TME), the long-term efficacy of therapy continues to be a clinical challenge. It is necessary to classify and refine the appropriate treatment intervention decision-making in this kind of tumor. Methods. We used ConsensusClusterPlus to establish a stable molecular classification based on the ferroptosis-related genes (FRGs) expression obtained from FerrDb. The clinical features, immune infiltration, DNA damage, and genomic changes of different subclasses were evaluated. The least absolute shrinkage and selection operator regression (LASSO) method and univariate Cox regression were utilized to construct the ferroptosis-related prognosis risk score (FPRS) model, and the association between the FPRS model and HCC molecular characteristics, immune features, and immunotherapy was studied. Results. We identified two ferroptosis subclasses, C1 with poor prognosis and a higher proportion of patients in the middle and late stages infected with HBV and HCV, having higher DNA damage including aneuploidy, HRD, fraction altered, and the number of segments, and higher probability of gene mutation and copy number mutation. FPRS model was constructed on the basis of differentially expressed genes (DEGs) between C1 and C2, which showed a higher area under the curve (AUC) in predicting overall survival rate in the training set and independent verification cohort and could reflect the clinical characteristics and response to immunotherapy of different patients, being an independent prognostic factor of HCC. Conclusion. Here, we revealed two novel molecular subgroups based on FRGs and develop an FPRS model consisting of six genes that can help predict prognosis and select patients suitable for immunotherapy." @default.
• W4220761323 created "2022-04-03" @default.
• W4220761323 creator A5014456836 @default.
• W4220761323 creator A5051782587 @default.
• W4220761323 creator A5052883326 @default.
• W4220761323 creator A5086210578 @default.
• W4220761323 creator A5086988401 @default.
• W4220761323 date "2022-03-12" @default.
• W4220761323 modified "2023-09-30" @default.
• W4220761323 title "The Detection and Verification of Two Heterogeneous Subgroups and a Risk Model Based on Ferroptosis-Related Genes in Hepatocellular Carcinoma" @default.
• W4220761323 cites W1967997862 @default.
• W4220761323 cites W1975514993 @default.
• W4220761323 cites W1985987855 @default.
• W4220761323 cites W1997183854 @default.
• W4220761323 cites W2023815439 @default.
• W4220761323 cites W2035618305 @default.
• W4220761323 cites W2099789788 @default.
• W4220761323 cites W2115462905 @default.
• W4220761323 cites W2130430382 @default.
• W4220761323 cites W2136415416 @default.
• W4220761323 cites W2146512944 @default.
• W4220761323 cites W2155943701 @default.
• W4220761323 cites W2163432985 @default.
• W4220761323 cites W2206214621 @default.
• W4220761323 cites W2214074259 @default.
• W4220761323 cites W2314057593 @default.
• W4220761323 cites W2574604975 @default.
• W4220761323 cites W2765565477 @default.
• W4220761323 cites W2767965002 @default.
• W4220761323 cites W2782803697 @default.
• W4220761323 cites W2786355530 @default.
• W4220761323 cites W2796207838 @default.
• W4220761323 cites W2888144978 @default.
• W4220761323 cites W2896872272 @default.
• W4220761323 cites W2948017644 @default.
• W4220761323 cites W2949273159 @default.
• W4220761323 cites W2952112680 @default.
• W4220761323 cites W3008188366 @default.
• W4220761323 cites W3013967177 @default.
• W4220761323 cites W3021818653 @default.
• W4220761323 cites W3042080013 @default.
• W4220761323 cites W3045029533 @default.
• W4220761323 cites W3093253494 @default.
• W4220761323 cites W3113289256 @default.
• W4220761323 cites W3128646645 @default.
• W4220761323 cites W3138896074 @default.
• W4220761323 cites W3160118848 @default.
• W4220761323 cites W3195038582 @default.
• W4220761323 cites W3202493769 @default.
• W4220761323 cites W3209702733 @default.
• W4220761323 doi "https://doi.org/10.1155/2022/1182383" @default.
• W4220761323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35313563" @default.
• W4220761323 hasPublicationYear "2022" @default.
• W4220761323 type Work @default.
• W4220761323 citedByCount "4" @default.
• W4220761323 countsByYear W42207613232022 @default.
• W4220761323 countsByYear W42207613232023 @default.
• W4220761323 crossrefType "journal-article" @default.
• W4220761323 hasAuthorship W4220761323A5014456836 @default.
• W4220761323 hasAuthorship W4220761323A5051782587 @default.
• W4220761323 hasAuthorship W4220761323A5052883326 @default.
• W4220761323 hasAuthorship W4220761323A5086210578 @default.
• W4220761323 hasAuthorship W4220761323A5086988401 @default.
• W4220761323 hasBestOaLocation W42207613231 @default.
• W4220761323 hasConcept C104317684 @default.
• W4220761323 hasConcept C121608353 @default.
• W4220761323 hasConcept C126322002 @default.
• W4220761323 hasConcept C136764020 @default.
• W4220761323 hasConcept C143998085 @default.
• W4220761323 hasConcept C203014093 @default.
• W4220761323 hasConcept C2777701055 @default.
• W4220761323 hasConcept C2778019345 @default.
• W4220761323 hasConcept C37616216 @default.
• W4220761323 hasConcept C41008148 @default.
• W4220761323 hasConcept C502942594 @default.
• W4220761323 hasConcept C50382708 @default.
• W4220761323 hasConcept C54355233 @default.
• W4220761323 hasConcept C71924100 @default.
• W4220761323 hasConcept C86803240 @default.
• W4220761323 hasConcept C8891405 @default.
• W4220761323 hasConceptScore W4220761323C104317684 @default.
• W4220761323 hasConceptScore W4220761323C121608353 @default.
• W4220761323 hasConceptScore W4220761323C126322002 @default.
• W4220761323 hasConceptScore W4220761323C136764020 @default.
• W4220761323 hasConceptScore W4220761323C143998085 @default.
• W4220761323 hasConceptScore W4220761323C203014093 @default.
• W4220761323 hasConceptScore W4220761323C2777701055 @default.
• W4220761323 hasConceptScore W4220761323C2778019345 @default.
• W4220761323 hasConceptScore W4220761323C37616216 @default.
• W4220761323 hasConceptScore W4220761323C41008148 @default.
• W4220761323 hasConceptScore W4220761323C502942594 @default.
• W4220761323 hasConceptScore W4220761323C50382708 @default.
• W4220761323 hasConceptScore W4220761323C54355233 @default.
• W4220761323 hasConceptScore W4220761323C71924100 @default.
• W4220761323 hasConceptScore W4220761323C86803240 @default.
• W4220761323 hasConceptScore W4220761323C8891405 @default.
• W4220761323 hasLocation W42207613231 @default.
• W4220761323 hasLocation W42207613232 @default.

• next