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- W4220761386 abstract "Glioblastoma (GBM) is a lethal brain cancer known for its potent immunosuppressive effects. Loss of Methylthioadenosine Phosphorylase (MTAP) expression, via gene deletion or epigenetic silencing, is one of the most common alterations in GBM. Here we show that MTAP loss in GBM cells is correlated with differential expression of immune regulatory genes. In silico analysis of gene expression profiles in GBM samples revealed that low MTAP expression is correlated with an increased proportion of M2 macrophages. Using in vitro macrophage models, we found that methylthioadenosine (MTA), the metabolite that accumulates as a result of MTAP loss in GBM cells, promotes the immunosuppressive alternative activation (M2) of macrophages. We show that this effect of MTA on macrophages is independent of IL4/IL3 signaling, is mediated by the adenosine A2B receptor, and can be pharmacologically reversed. This study suggests that MTAP loss in GBM cells may contribute to the immunosuppressive tumor microenvironment, and that MTAP status should be considered for characterizing GBM immune states and devising immunotherapy-based approaches for treating MTAP-null GBM." @default.
- W4220761386 created "2022-04-03" @default.
- W4220761386 creator A5000731827 @default.
- W4220761386 creator A5021569860 @default.
- W4220761386 creator A5038247833 @default.
- W4220761386 creator A5046203392 @default.
- W4220761386 creator A5048382247 @default.
- W4220761386 creator A5059485677 @default.
- W4220761386 creator A5062250223 @default.
- W4220761386 creator A5080611527 @default.
- W4220761386 date "2022-03-09" @default.
- W4220761386 modified "2023-10-01" @default.
- W4220761386 title "MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization" @default.
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