FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220761716> ?p ?o ?g. }

• W4220761716 endingPage "109" @default.
• W4220761716 startingPage "98" @default.
• W4220761716 abstract "While altered expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type receptor has been reported in postmortem studies of schizophrenia, these findings are inconsistent. Therefore, we aimed to systematically review postmortem studies that investigated AMPA receptor expressions in schizophrenia.A systematic literature search was conducted for postmortem studies that measured AMPA receptor subunit expressions or receptor bindings in schizophrenia compared to healthy individuals on February 3, 2021, using Medline and Embase.A total of 39 relevant articles were identified from 1360 initial reports. The dorsolateral prefrontal cortex (DLPFC) was the most investigated region (15 studies), followed by the medial temporal lobe (8 studies). For the DLPFC, 4/15 studies (26.7%) showed increased AMPA receptor binding or subunit expression in patients with schizophrenia compared to that in controls, especially in GRIA1 and GRIA4, 2/15 studies (13.3%) reported a decrease, particularly in GRIA2, and 8/15 studies (56.7%) found no significant differences. A decreased expression or receptor binding was observed in 6/8 studies (75.0%) in the subregions of the hippocampus in patients with schizophrenia compared to that in controls, whereas the other two studies found no significant differences.Published data have reported decreased subunit expression or receptor binding in the hippocampus in schizophrenia. These findings were inconsistent in other brain regions, which might be due to the heterogeneity of this population, various study design, physiological changes after death, and limited number of studies. Future in vivo studies are warranted to examine AMPA receptor expressions in human brains, together with their comprehensive clinical characterization." @default.
• W4220761716 created "2022-04-03" @default.
• W4220761716 creator A5000318706 @default.
• W4220761716 creator A5005264920 @default.
• W4220761716 creator A5014162780 @default.
• W4220761716 creator A5021932877 @default.
• W4220761716 creator A5033519257 @default.
• W4220761716 creator A5043573908 @default.
• W4220761716 creator A5057023665 @default.
• W4220761716 creator A5061187943 @default.
• W4220761716 creator A5061811239 @default.
• W4220761716 date "2022-05-01" @default.
• W4220761716 modified "2023-10-18" @default.
• W4220761716 title "AMPA receptors in schizophrenia: A systematic review of postmortem studies on receptor subunit expression and binding" @default.
• W4220761716 cites W1533324384 @default.
• W4220761716 cites W1906444297 @default.
• W4220761716 cites W1964289335 @default.
• W4220761716 cites W1965507972 @default.
• W4220761716 cites W1966057857 @default.
• W4220761716 cites W1967658024 @default.
• W4220761716 cites W1975788909 @default.
• W4220761716 cites W1978817835 @default.
• W4220761716 cites W1980486154 @default.
• W4220761716 cites W1990286087 @default.
• W4220761716 cites W1990348029 @default.
• W4220761716 cites W1990964050 @default.
• W4220761716 cites W1992232671 @default.
• W4220761716 cites W1993683682 @default.
• W4220761716 cites W1994267687 @default.
• W4220761716 cites W1996491588 @default.
• W4220761716 cites W2000767080 @default.
• W4220761716 cites W2007924853 @default.
• W4220761716 cites W2012678641 @default.
• W4220761716 cites W2014167042 @default.
• W4220761716 cites W2015650391 @default.
• W4220761716 cites W2021101169 @default.
• W4220761716 cites W2024278554 @default.
• W4220761716 cites W2026710381 @default.
• W4220761716 cites W2028669852 @default.
• W4220761716 cites W2028884770 @default.
• W4220761716 cites W2042753686 @default.
• W4220761716 cites W2044384095 @default.
• W4220761716 cites W2047758646 @default.
• W4220761716 cites W2048024033 @default.
• W4220761716 cites W2048855971 @default.
• W4220761716 cites W2056366478 @default.
• W4220761716 cites W2058387509 @default.
• W4220761716 cites W2058934183 @default.
• W4220761716 cites W2063409933 @default.
• W4220761716 cites W2063987809 @default.
• W4220761716 cites W2066399961 @default.
• W4220761716 cites W2067409878 @default.
• W4220761716 cites W2067915400 @default.
• W4220761716 cites W2073845233 @default.
• W4220761716 cites W2076899555 @default.
• W4220761716 cites W2077874409 @default.
• W4220761716 cites W2079841710 @default.
• W4220761716 cites W2085003759 @default.
• W4220761716 cites W2090694271 @default.
• W4220761716 cites W2092042021 @default.
• W4220761716 cites W2093116784 @default.
• W4220761716 cites W2101357408 @default.
• W4220761716 cites W2101494517 @default.
• W4220761716 cites W2108968692 @default.
• W4220761716 cites W2110008349 @default.
• W4220761716 cites W2110534885 @default.
• W4220761716 cites W2113773514 @default.
• W4220761716 cites W2115807273 @default.
• W4220761716 cites W2121407089 @default.
• W4220761716 cites W2124300506 @default.
• W4220761716 cites W2125648698 @default.
• W4220761716 cites W2128574573 @default.
• W4220761716 cites W2129108032 @default.
• W4220761716 cites W2133623572 @default.
• W4220761716 cites W2139078690 @default.
• W4220761716 cites W2143146123 @default.
• W4220761716 cites W2143417330 @default.
• W4220761716 cites W2156098321 @default.
• W4220761716 cites W2164799222 @default.
• W4220761716 cites W2330826013 @default.
• W4220761716 cites W2424710696 @default.
• W4220761716 cites W2436087278 @default.
• W4220761716 cites W2509143449 @default.
• W4220761716 cites W2560822022 @default.
• W4220761716 cites W2735674872 @default.
• W4220761716 cites W2886587096 @default.
• W4220761716 cites W2898344414 @default.
• W4220761716 cites W2944450515 @default.
• W4220761716 cites W2970374982 @default.
• W4220761716 cites W2990923180 @default.
• W4220761716 cites W2991792334 @default.
• W4220761716 cites W2999688222 @default.
• W4220761716 cites W3118790847 @default.
• W4220761716 cites W3119454518 @default.
• W4220761716 cites W3121165943 @default.
• W4220761716 cites W3165179400 @default.
• W4220761716 cites W4211075559 @default.
• W4220761716 cites W4231232311 @default.

• next