FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220761750> ?p ?o ?g. }

• W4220761750 endingPage "1686" @default.
• W4220761750 startingPage "1677" @default.
• W4220761750 abstract "Based on network pharmacology, the mechanism of Polygoni Cuspidati Rhizoma et Radix-Ligustri Lucidi Fructus(PL) combination against acute gouty arthritis(AGA) was explored and preliminarily verified by animal experiment. The chemical components and corresponding targets of PL were retrieved from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP). The active components with oral bioavailability(OB)≥30% and drug-likeness(DL)≥0.18 were screened based on literature, and the related protein targets were collected. Then the protein targets were standardized with the help of UniProt database. The AGA-related targets were searched from GeneCards, NCBI, and DrugBank. The common targets of the disease and the medicinals were yielded by FunRich V3, and the protein-protein interaction(PPI) network was constructed to screen the key targets, followed by Gene Ontology(GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis of the key targets. Afterwards, some of the key targets were verified by sodium urate crystal-induced AGA mouse model. A total of 25 active components and 287 targets of PL, 811 targets of AGA, and 88 common targets were screened out. PPI network analysis showed that tumor necrosis factor(TNF), interleukin-6(IL-6), and interleukin-1β(IL-1β) may be the core targets of PL in the treatment of AGA. The key targets were mainly involved in 566 GO terms(P<0.05), including multiple biological processes such as inflammatory response and immune response. Moreover, they were related to 116 KEGG pathways and these pathways were involved in inflammation and immunity, mainly including NOD-like receptor signaling pathway and TNF signaling pathway. Animal experiment confirmed that PL can alleviate ankle swelling, improve abnormal gait, and down-regulate the protein expression of TNF-α, IL-6, and IL-1β in AGA mice, indicating that PL can treat AGA through TNF-α, IL-6, and IL-1β and the feasibility of network pharmacology to predict drug targets. This study preliminarily discussed the key targets and biological signaling pathways involved in the treatment of AGA with PL combination, which reflected the multi-pathway and multi-target action characteristics of Chinese medicine. Moreover, this study laid a scientific basis for research on the treatment of AGA with PL combination, as well as the mechanism of action." @default.
• W4220761750 created "2022-04-03" @default.
• W4220761750 creator A5029941351 @default.
• W4220761750 creator A5041111499 @default.
• W4220761750 creator A5044513573 @default.
• W4220761750 creator A5064759528 @default.
• W4220761750 creator A5085643062 @default.
• W4220761750 date "2022-03-01" @default.
• W4220761750 modified "2023-09-25" @default.
• W4220761750 title "[Mechanism and experimental verification of Polygoni Cuspidati Rhizoma et Radix-Ligustri Lucidi Fructus combination in treatment of acute gouty arthritis based on network pharmacology]." @default.
• W4220761750 doi "https://doi.org/10.19540/j.cnki.cjcmm.20211103.402" @default.
• W4220761750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35347967" @default.
• W4220761750 hasPublicationYear "2022" @default.
• W4220761750 type Work @default.
• W4220761750 citedByCount "0" @default.
• W4220761750 crossrefType "journal-article" @default.
• W4220761750 hasAuthorship W4220761750A5029941351 @default.
• W4220761750 hasAuthorship W4220761750A5041111499 @default.
• W4220761750 hasAuthorship W4220761750A5044513573 @default.
• W4220761750 hasAuthorship W4220761750A5064759528 @default.
• W4220761750 hasAuthorship W4220761750A5085643062 @default.
• W4220761750 hasConcept C104317684 @default.
• W4220761750 hasConcept C142724271 @default.
• W4220761750 hasConcept C150194340 @default.
• W4220761750 hasConcept C152724338 @default.
• W4220761750 hasConcept C155261790 @default.
• W4220761750 hasConcept C158180186 @default.
• W4220761750 hasConcept C188947578 @default.
• W4220761750 hasConcept C202264299 @default.
• W4220761750 hasConcept C204787440 @default.
• W4220761750 hasConcept C2779091547 @default.
• W4220761750 hasConcept C2779446555 @default.
• W4220761750 hasConcept C2780035454 @default.
• W4220761750 hasConcept C2911069016 @default.
• W4220761750 hasConcept C2987395477 @default.
• W4220761750 hasConcept C54174078 @default.
• W4220761750 hasConcept C55493867 @default.
• W4220761750 hasConcept C556039675 @default.
• W4220761750 hasConcept C59822182 @default.
• W4220761750 hasConcept C62478195 @default.
• W4220761750 hasConcept C70721500 @default.
• W4220761750 hasConcept C71924100 @default.
• W4220761750 hasConcept C86803240 @default.
• W4220761750 hasConcept C98274493 @default.
• W4220761750 hasConceptScore W4220761750C104317684 @default.
• W4220761750 hasConceptScore W4220761750C142724271 @default.
• W4220761750 hasConceptScore W4220761750C150194340 @default.
• W4220761750 hasConceptScore W4220761750C152724338 @default.
• W4220761750 hasConceptScore W4220761750C155261790 @default.
• W4220761750 hasConceptScore W4220761750C158180186 @default.
• W4220761750 hasConceptScore W4220761750C188947578 @default.
• W4220761750 hasConceptScore W4220761750C202264299 @default.
• W4220761750 hasConceptScore W4220761750C204787440 @default.
• W4220761750 hasConceptScore W4220761750C2779091547 @default.
• W4220761750 hasConceptScore W4220761750C2779446555 @default.
• W4220761750 hasConceptScore W4220761750C2780035454 @default.
• W4220761750 hasConceptScore W4220761750C2911069016 @default.
• W4220761750 hasConceptScore W4220761750C2987395477 @default.
• W4220761750 hasConceptScore W4220761750C54174078 @default.
• W4220761750 hasConceptScore W4220761750C55493867 @default.
• W4220761750 hasConceptScore W4220761750C556039675 @default.
• W4220761750 hasConceptScore W4220761750C59822182 @default.
• W4220761750 hasConceptScore W4220761750C62478195 @default.
• W4220761750 hasConceptScore W4220761750C70721500 @default.
• W4220761750 hasConceptScore W4220761750C71924100 @default.
• W4220761750 hasConceptScore W4220761750C86803240 @default.
• W4220761750 hasConceptScore W4220761750C98274493 @default.
• W4220761750 hasIssue "6" @default.
• W4220761750 hasLocation W42207617501 @default.
• W4220761750 hasOpenAccess W4220761750 @default.
• W4220761750 hasPrimaryLocation W42207617501 @default.
• W4220761750 hasRelatedWork W11570197 @default.
• W4220761750 hasRelatedWork W11710015 @default.
• W4220761750 hasRelatedWork W3930036 @default.
• W4220761750 hasRelatedWork W3980403 @default.
• W4220761750 hasRelatedWork W4013220 @default.
• W4220761750 hasRelatedWork W5012469 @default.
• W4220761750 hasRelatedWork W5532361 @default.
• W4220761750 hasRelatedWork W8725036 @default.
• W4220761750 hasRelatedWork W8912392 @default.
• W4220761750 hasRelatedWork W9371396 @default.
• W4220761750 hasVolume "47" @default.
• W4220761750 isParatext "false" @default.
• W4220761750 isRetracted "false" @default.
• W4220761750 workType "article" @default.