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- W4220761760 endingPage "12" @default.
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- W4220761760 abstract "BH3 mimetics constitute a novel concept of antitumor therapy, inducing apoptosis via inhibition of pro-survival BCL-2 proteins. Programmed cell death is fundamental for physiological hematopoiesis; hence hematological side effects of these compounds are conceivable. Navitoclax and venetoclax have been studied extensively in the clinical setting; our knowledge of the more recently developed BCL-2 protein inhibitors specifically targeting MCL-1 or BCL-XL, however, is restricted mainly to preclinical experiments. To delineate possible adverse effects of novel BH3 mimetics on the human hematopoietic system, this review summarizes current knowledge of the function of specific antiapoptotic BCL-2 proteins in physiological hematopoiesis." @default.
- W4220761760 created "2022-04-03" @default.
- W4220761760 creator A5012624441 @default.
- W4220761760 creator A5022783459 @default.
- W4220761760 creator A5048860862 @default.
- W4220761760 creator A5091482610 @default.
- W4220761760 date "2022-06-01" @default.
- W4220761760 modified "2023-10-01" @default.
- W4220761760 title "Stayin’ alive: BCL-2 proteins in the hematopoietic system" @default.
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