FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220762260> ?p ?o ?g. }

• W4220762260 endingPage "1336" @default.
• W4220762260 startingPage "1325" @default.
• W4220762260 abstract "The risk assessment classification schemes for gastrointestinal stromal tumors (GIST) include tumor site, size, mitotic count and variably tumor rupture. Heterogeneity in high-risk GIST poses limitations for current classification schemes. This study aims to demonstrate the clinical utility of risk stratification by gene expression profiling (GEP) using Nanostring technology.Fifty-six GIST cases were analyzed using a 231 gene expression panel. GEP results were correlated with clinical and pathological data. The prognostic performance was assessed in 34 patients with available survival data using ROC curves, Kaplan-Meier survival curves and compared with traditional risk assessment schemes. Volcano plot analysis identified seven genes with significantly higher expression (FDR < .0.05) in high-risk than in non-high-risk tumors, namely TYMS, CDC2, TOP2A, CCNA2, E2F1, PCNA, and BIRC5. Together, these transcripts exhibited significantly higher expression in high-risk tumors than in intermediate (P < 0.01), low (P < 0.001), and very low (P = 0.01) risk tumors. Receiver-operating characteristic curve analysis demonstrated area under the curve (AUC) to be 0.858 for the separation of high-risk and non-high-risk tumors. Kaplan-Meier survival analysis demonstrated improved risk stratification (log-rank test P < 0.001) compared to the current risk assessment classification (P = 0.231).In addition to current clinical and histology-based risk classification for patients with GIST, gene expression may offer complementary prognostic information." @default.
• W4220762260 created "2022-04-03" @default.
• W4220762260 creator A5012161690 @default.
• W4220762260 creator A5042679986 @default.
• W4220762260 creator A5047482077 @default.
• W4220762260 creator A5048954949 @default.
• W4220762260 creator A5056075993 @default.
• W4220762260 creator A5057751172 @default.
• W4220762260 creator A5087295236 @default.
• W4220762260 date "2022-01-28" @default.
• W4220762260 modified "2023-09-27" @default.
• W4220762260 title "Risk stratification of gastrointestinal stromal tumors by Nanostring gene expression profiling" @default.
• W4220762260 cites W1777424104 @default.
• W4220762260 cites W1967297034 @default.
• W4220762260 cites W1973205885 @default.
• W4220762260 cites W1976022788 @default.
• W4220762260 cites W1981491302 @default.
• W4220762260 cites W1989277387 @default.
• W4220762260 cites W1995830102 @default.
• W4220762260 cites W1999893493 @default.
• W4220762260 cites W2008920989 @default.
• W4220762260 cites W2009847758 @default.
• W4220762260 cites W2010415450 @default.
• W4220762260 cites W2012208277 @default.
• W4220762260 cites W2022195787 @default.
• W4220762260 cites W2025447556 @default.
• W4220762260 cites W2032771230 @default.
• W4220762260 cites W2035214704 @default.
• W4220762260 cites W2049885981 @default.
• W4220762260 cites W2053911257 @default.
• W4220762260 cites W2068550669 @default.
• W4220762260 cites W2068926954 @default.
• W4220762260 cites W2072047798 @default.
• W4220762260 cites W2072284307 @default.
• W4220762260 cites W2092105161 @default.
• W4220762260 cites W2103017472 @default.
• W4220762260 cites W2103304755 @default.
• W4220762260 cites W2108081301 @default.
• W4220762260 cites W2115504770 @default.
• W4220762260 cites W2115768226 @default.
• W4220762260 cites W2118632896 @default.
• W4220762260 cites W2123106337 @default.
• W4220762260 cites W2128032087 @default.
• W4220762260 cites W2130410032 @default.
• W4220762260 cites W2138902620 @default.
• W4220762260 cites W2142499403 @default.
• W4220762260 cites W2151611826 @default.
• W4220762260 cites W2178731684 @default.
• W4220762260 cites W2264032381 @default.
• W4220762260 cites W2406195324 @default.
• W4220762260 cites W2562594282 @default.
• W4220762260 cites W2579985413 @default.
• W4220762260 cites W2592550483 @default.
• W4220762260 cites W2604461259 @default.
• W4220762260 cites W2618986566 @default.
• W4220762260 cites W2886565893 @default.
• W4220762260 cites W2952481429 @default.
• W4220762260 cites W4233698560 @default.
• W4220762260 cites W4238208852 @default.
• W4220762260 cites W2109951302 @default.
• W4220762260 doi "https://doi.org/10.1007/s00432-022-03924-3" @default.
• W4220762260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35089395" @default.
• W4220762260 hasPublicationYear "2022" @default.
• W4220762260 type Work @default.
• W4220762260 citedByCount "1" @default.
• W4220762260 countsByYear W42207622602022 @default.
• W4220762260 crossrefType "journal-article" @default.
• W4220762260 hasAuthorship W4220762260A5012161690 @default.
• W4220762260 hasAuthorship W4220762260A5042679986 @default.
• W4220762260 hasAuthorship W4220762260A5047482077 @default.
• W4220762260 hasAuthorship W4220762260A5048954949 @default.
• W4220762260 hasAuthorship W4220762260A5056075993 @default.
• W4220762260 hasAuthorship W4220762260A5057751172 @default.
• W4220762260 hasAuthorship W4220762260A5087295236 @default.
• W4220762260 hasBestOaLocation W42207622602 @default.
• W4220762260 hasConcept C104317684 @default.
• W4220762260 hasConcept C10515644 @default.
• W4220762260 hasConcept C11783203 @default.
• W4220762260 hasConcept C12174686 @default.
• W4220762260 hasConcept C126322002 @default.
• W4220762260 hasConcept C143998085 @default.
• W4220762260 hasConcept C150194340 @default.
• W4220762260 hasConcept C16930146 @default.
• W4220762260 hasConcept C18431079 @default.
• W4220762260 hasConcept C2775922572 @default.
• W4220762260 hasConcept C2779134260 @default.
• W4220762260 hasConcept C3020404979 @default.
• W4220762260 hasConcept C38652104 @default.
• W4220762260 hasConcept C41008148 @default.
• W4220762260 hasConcept C50382708 @default.
• W4220762260 hasConcept C55493867 @default.
• W4220762260 hasConcept C58471807 @default.
• W4220762260 hasConcept C71924100 @default.
• W4220762260 hasConcept C86803240 @default.
• W4220762260 hasConceptScore W4220762260C104317684 @default.
• W4220762260 hasConceptScore W4220762260C10515644 @default.
• W4220762260 hasConceptScore W4220762260C11783203 @default.
• W4220762260 hasConceptScore W4220762260C12174686 @default.

• next