Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220762263> ?p ?o ?g. }
- W4220762263 endingPage "204173142210840" @default.
- W4220762263 startingPage "204173142210840" @default.
- W4220762263 abstract "Apical periodontitis (AP) causes arrest of tooth root development, which is associated with impaired odontoblastic differentiation of stem cells from apical papilla (SCAPs), but the underlying mechanism remains unclear. Here, we investigated roles of extracellular vesicle (EV) in AP and odontoblastic differentiation of SCAPs, moreover, a novel nuclear factor I/C (NFIC)-encapsulated EV was developed to promote dentin regeneration. We detected a higher expression of EV marker CD63 in inflamed apical papilla, and found that EVs from LPS-stimulated dental pulp cells suppressed odontoblastic differentiation of SCAPs through downregulating NFIC. Furthermore, we successfully constructed the NFIC-encapsulated EV by overexpressing NFIC in HEK293FT cells, which could upregulate cellular NFIC level in SCAPs, promoting the proliferation and migration of SCAPs, as well as dentinogenesis both in vitro and in vivo. Collectively, based on pathological roles of EV in AP, our study provides a novel strategy for dentin regeneration by exploiting EV to deliver NFIC." @default.
- W4220762263 created "2022-04-03" @default.
- W4220762263 creator A5002099124 @default.
- W4220762263 creator A5006259312 @default.
- W4220762263 creator A5017941291 @default.
- W4220762263 creator A5021411903 @default.
- W4220762263 creator A5030190286 @default.
- W4220762263 creator A5041256730 @default.
- W4220762263 creator A5047609104 @default.
- W4220762263 creator A5060335364 @default.
- W4220762263 creator A5063104330 @default.
- W4220762263 date "2022-01-01" @default.
- W4220762263 modified "2023-10-16" @default.
- W4220762263 title "Extracellular vesicles delivering nuclear factor I/C for hard tissue engineering: Treatment of apical periodontitis and dentin regeneration" @default.
- W4220762263 cites W1974543096 @default.
- W4220762263 cites W2014145369 @default.
- W4220762263 cites W2023989480 @default.
- W4220762263 cites W2046342087 @default.
- W4220762263 cites W2050664881 @default.
- W4220762263 cites W2098863391 @default.
- W4220762263 cites W2135651311 @default.
- W4220762263 cites W2138284463 @default.
- W4220762263 cites W2279102027 @default.
- W4220762263 cites W2514206815 @default.
- W4220762263 cites W2526445427 @default.
- W4220762263 cites W2547129703 @default.
- W4220762263 cites W2607544365 @default.
- W4220762263 cites W2724386338 @default.
- W4220762263 cites W2783934455 @default.
- W4220762263 cites W2786514708 @default.
- W4220762263 cites W2791126322 @default.
- W4220762263 cites W2793760887 @default.
- W4220762263 cites W2800046588 @default.
- W4220762263 cites W2800659616 @default.
- W4220762263 cites W2863980947 @default.
- W4220762263 cites W2914009050 @default.
- W4220762263 cites W2946645851 @default.
- W4220762263 cites W2949356248 @default.
- W4220762263 cites W2955452369 @default.
- W4220762263 cites W2957275004 @default.
- W4220762263 cites W2970718184 @default.
- W4220762263 cites W2970752061 @default.
- W4220762263 cites W2974434865 @default.
- W4220762263 cites W2988677495 @default.
- W4220762263 cites W2991287507 @default.
- W4220762263 cites W3001023258 @default.
- W4220762263 cites W3005104290 @default.
- W4220762263 cites W3006566616 @default.
- W4220762263 cites W3011557809 @default.
- W4220762263 cites W3016824415 @default.
- W4220762263 cites W3017240959 @default.
- W4220762263 cites W3023667710 @default.
- W4220762263 cites W3028960763 @default.
- W4220762263 cites W3029285152 @default.
- W4220762263 cites W3031627183 @default.
- W4220762263 cites W3032105658 @default.
- W4220762263 cites W3034563020 @default.
- W4220762263 cites W3044936974 @default.
- W4220762263 cites W3046637292 @default.
- W4220762263 cites W3082084030 @default.
- W4220762263 cites W3084484613 @default.
- W4220762263 cites W3106681759 @default.
- W4220762263 cites W3108337286 @default.
- W4220762263 cites W3114942846 @default.
- W4220762263 cites W3140786300 @default.
- W4220762263 cites W3143156214 @default.
- W4220762263 cites W3154868467 @default.
- W4220762263 cites W3175628958 @default.
- W4220762263 cites W3188918039 @default.
- W4220762263 cites W3207093085 @default.
- W4220762263 cites W3214886624 @default.
- W4220762263 cites W3215989640 @default.
- W4220762263 cites W4206239721 @default.
- W4220762263 cites W570470178 @default.
- W4220762263 doi "https://doi.org/10.1177/20417314221084095" @default.
- W4220762263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35321254" @default.
- W4220762263 hasPublicationYear "2022" @default.
- W4220762263 type Work @default.
- W4220762263 citedByCount "8" @default.
- W4220762263 countsByYear W42207622632022 @default.
- W4220762263 countsByYear W42207622632023 @default.
- W4220762263 crossrefType "journal-article" @default.
- W4220762263 hasAuthorship W4220762263A5002099124 @default.
- W4220762263 hasAuthorship W4220762263A5006259312 @default.
- W4220762263 hasAuthorship W4220762263A5017941291 @default.
- W4220762263 hasAuthorship W4220762263A5021411903 @default.
- W4220762263 hasAuthorship W4220762263A5030190286 @default.
- W4220762263 hasAuthorship W4220762263A5041256730 @default.
- W4220762263 hasAuthorship W4220762263A5047609104 @default.
- W4220762263 hasAuthorship W4220762263A5060335364 @default.
- W4220762263 hasAuthorship W4220762263A5063104330 @default.
- W4220762263 hasBestOaLocation W42207622631 @default.
- W4220762263 hasConcept C105702510 @default.
- W4220762263 hasConcept C142724271 @default.
- W4220762263 hasConcept C171056886 @default.
- W4220762263 hasConcept C185592680 @default.
- W4220762263 hasConcept C2520015 @default.
- W4220762263 hasConcept C2777894202 @default.