FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220762854> ?p ?o ?g. }

• W4220762854 abstract "Although both copy number variations (CNVs) and single nucleotide variations (SNVs) detected by single-cell RNA sequencing (scRNA-seq) are used to study intratumor heterogeneity and detect clonal groups, a software that integrates these two types of data in the same cells is unavailable.We developed Clonal Architecture with Integration of SNV and CNV (CAISC), an R package for scRNA-seq data analysis that clusters single cells into distinct subclones by integrating CNV and SNV genotype matrices using an entropy weighted approach. The performance of CAISC was tested on simulation data and four real datasets, which confirmed its high accuracy in sub-clonal identification and assignment, including subclones which cannot be identified using one type of data alone. Furthermore, integration of SNV and CNV allowed for accurate examination of expression changes between subclones, as demonstrated by the results from trisomy 8 clones of the myelodysplastic syndromes (MDS) dataset.CAISC is a powerful tool for integration of CNV and SNV data from scRNA-seq to identify clonal clusters with better accuracy than obtained from a single type of data. CAISC allows users to interactively examine clonal assignments." @default.
• W4220762854 created "2022-04-03" @default.
• W4220762854 creator A5029264687 @default.
• W4220762854 creator A5047493607 @default.
• W4220762854 creator A5052494094 @default.
• W4220762854 creator A5072063614 @default.
• W4220762854 creator A5090749715 @default.
• W4220762854 date "2022-03-01" @default.
• W4220762854 modified "2023-10-09" @default.
• W4220762854 title "CAISC: A software to integrate copy number variations and single nucleotide mutations for genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing" @default.
• W4220762854 cites W1572656384 @default.
• W4220762854 cites W2011637823 @default.
• W4220762854 cites W2023887100 @default.
• W4220762854 cites W2030017878 @default.
• W4220762854 cites W2032518018 @default.
• W4220762854 cites W2042162405 @default.
• W4220762854 cites W2060900396 @default.
• W4220762854 cites W2071949631 @default.
• W4220762854 cites W2090461073 @default.
• W4220762854 cites W2119180969 @default.
• W4220762854 cites W2136170412 @default.
• W4220762854 cites W2137586531 @default.
• W4220762854 cites W2139031797 @default.
• W4220762854 cites W2281397941 @default.
• W4220762854 cites W2301970471 @default.
• W4220762854 cites W2342423616 @default.
• W4220762854 cites W2425449982 @default.
• W4220762854 cites W2515472395 @default.
• W4220762854 cites W2546514099 @default.
• W4220762854 cites W2610509384 @default.
• W4220762854 cites W2738946651 @default.
• W4220762854 cites W2760824708 @default.
• W4220762854 cites W2779149735 @default.
• W4220762854 cites W2795441313 @default.
• W4220762854 cites W2952630931 @default.
• W4220762854 cites W2953517386 @default.
• W4220762854 cites W2989292515 @default.
• W4220762854 cites W3000756465 @default.
• W4220762854 cites W3008591269 @default.
• W4220762854 cites W3011619834 @default.
• W4220762854 cites W3017999335 @default.
• W4220762854 cites W3027826979 @default.
• W4220762854 cites W3095901003 @default.
• W4220762854 doi "https://doi.org/10.1186/s12859-022-04625-x" @default.
• W4220762854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35313800" @default.
• W4220762854 hasPublicationYear "2022" @default.
• W4220762854 type Work @default.
• W4220762854 citedByCount "0" @default.
• W4220762854 crossrefType "journal-article" @default.
• W4220762854 hasAuthorship W4220762854A5029264687 @default.
• W4220762854 hasAuthorship W4220762854A5047493607 @default.
• W4220762854 hasAuthorship W4220762854A5052494094 @default.
• W4220762854 hasAuthorship W4220762854A5072063614 @default.
• W4220762854 hasAuthorship W4220762854A5090749715 @default.
• W4220762854 hasBestOaLocation W42207628541 @default.
• W4220762854 hasConcept C104317684 @default.
• W4220762854 hasConcept C113968399 @default.
• W4220762854 hasConcept C120821319 @default.
• W4220762854 hasConcept C141231307 @default.
• W4220762854 hasConcept C150194340 @default.
• W4220762854 hasConcept C16671776 @default.
• W4220762854 hasConcept C174749747 @default.
• W4220762854 hasConcept C192800701 @default.
• W4220762854 hasConcept C501734568 @default.
• W4220762854 hasConcept C51679486 @default.
• W4220762854 hasConcept C54355233 @default.
• W4220762854 hasConcept C70721500 @default.
• W4220762854 hasConcept C86803240 @default.
• W4220762854 hasConcept C95371953 @default.
• W4220762854 hasConceptScore W4220762854C104317684 @default.
• W4220762854 hasConceptScore W4220762854C113968399 @default.
• W4220762854 hasConceptScore W4220762854C120821319 @default.
• W4220762854 hasConceptScore W4220762854C141231307 @default.
• W4220762854 hasConceptScore W4220762854C150194340 @default.
• W4220762854 hasConceptScore W4220762854C16671776 @default.
• W4220762854 hasConceptScore W4220762854C174749747 @default.
• W4220762854 hasConceptScore W4220762854C192800701 @default.
• W4220762854 hasConceptScore W4220762854C501734568 @default.
• W4220762854 hasConceptScore W4220762854C51679486 @default.
• W4220762854 hasConceptScore W4220762854C54355233 @default.
• W4220762854 hasConceptScore W4220762854C70721500 @default.
• W4220762854 hasConceptScore W4220762854C86803240 @default.
• W4220762854 hasConceptScore W4220762854C95371953 @default.
• W4220762854 hasFunder F4320332161 @default.
• W4220762854 hasIssue "S3" @default.
• W4220762854 hasLocation W42207628541 @default.
• W4220762854 hasLocation W42207628542 @default.
• W4220762854 hasLocation W42207628543 @default.
• W4220762854 hasOpenAccess W4220762854 @default.
• W4220762854 hasPrimaryLocation W42207628541 @default.
• W4220762854 hasRelatedWork W2411766195 @default.
• W4220762854 hasRelatedWork W2762224802 @default.
• W4220762854 hasRelatedWork W2809058112 @default.
• W4220762854 hasRelatedWork W2905558664 @default.
• W4220762854 hasRelatedWork W2955906052 @default.
• W4220762854 hasRelatedWork W2980374641 @default.
• W4220762854 hasRelatedWork W3029029205 @default.
• W4220762854 hasRelatedWork W3035503811 @default.
• W4220762854 hasRelatedWork W4220852060 @default.
• W4220762854 hasRelatedWork W779505722 @default.

• next