FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220763457> ?p ?o ?g. }

• W4220763457 endingPage "327" @default.
• W4220763457 startingPage "317" @default.
• W4220763457 abstract "Peimine (PM) is a bioactive compound obtained from Fritillaria. It has been documented that PM exhibits potent antitumor properties against multiple cancers. However, the antitumor properties of PM in breast cancer and its associated mechanisms have not been clarified.Proliferation and apoptosis of MCF-7 and MCF-10A cells were detected by CCK8, colony formation, and flow cytometry assays. Cytotoxicity was measured by Lactate dehydrogenase (LDH) leakage assay. The level of IL-1β and IL-18 were detected with ELISA kits. Western blotting and real-time Polymerase Chain Reaction were performed to analyze the expression of proteins and genes related to the NLRP3 inflammasome pathway and Endoplasmic reticulum stress.The doses of PM (5, 10, and 20 μM) inhibited cell viability significantly, apoptotic induction, and inflammasome activation in breast cancer cells in vitro. Inflammasome components were decreased, including the apoptosisassociated speck like protein containing a CARD (ASC) and NOD-like receptor pyrindomain-containing protein3 (NLRP3), as well as the inhibition of caspase-1 and interleukin-1β activation. Moreover, inflammasome inhibitors suppressed cell growth and induced apoptosis, implying that PM suppresses the growth of breast cancer cells through regulating inflammasome. Mechanistically, PM inhibited the activity of inflammasome by alleviating endoplasmic reticulum (ER) stress and by down-regulating the expression of multiple proteins in transcription factor nuclear factor- κB (NF-κB) and mitogen-activated protein kinases (MAPKs) signaling pathways.These findings show that PM suppresses the growth of breast cancer cells by inhibiting inflammasome activation, to a certain extent, by primarily acting on the MAPK/NF-κB pathway's inactivation-dependent mechanisms." @default.
• W4220763457 created "2022-04-03" @default.
• W4220763457 creator A5012677271 @default.
• W4220763457 creator A5039913914 @default.
• W4220763457 creator A5043667195 @default.
• W4220763457 creator A5087052969 @default.
• W4220763457 date "2023-02-01" @default.
• W4220763457 modified "2023-09-27" @default.
• W4220763457 title "Peimine Inhibits MCF-7 Breast Cancer Cell Growth by Modulating Inflammasome Activation: Critical Roles of MAPK and NF-κB Signaling" @default.
• W4220763457 cites W2006917873 @default.
• W4220763457 cites W2014460314 @default.
• W4220763457 cites W2067006826 @default.
• W4220763457 cites W2281518043 @default.
• W4220763457 cites W2331564595 @default.
• W4220763457 cites W2583653513 @default.
• W4220763457 cites W2589060305 @default.
• W4220763457 cites W2620027809 @default.
• W4220763457 cites W2739819331 @default.
• W4220763457 cites W2766528308 @default.
• W4220763457 cites W2790856676 @default.
• W4220763457 cites W2805363086 @default.
• W4220763457 cites W2885558936 @default.
• W4220763457 cites W2897298828 @default.
• W4220763457 cites W2898306498 @default.
• W4220763457 cites W2901171191 @default.
• W4220763457 cites W2915763610 @default.
• W4220763457 cites W2923883554 @default.
• W4220763457 cites W2944835160 @default.
• W4220763457 cites W2945861489 @default.
• W4220763457 cites W2954782052 @default.
• W4220763457 cites W2963199063 @default.
• W4220763457 cites W2971694526 @default.
• W4220763457 cites W2976001270 @default.
• W4220763457 cites W2982045176 @default.
• W4220763457 cites W2991772838 @default.
• W4220763457 cites W2992396212 @default.
• W4220763457 cites W3026572993 @default.
• W4220763457 cites W3036446761 @default.
• W4220763457 cites W3047400254 @default.
• W4220763457 cites W3048159287 @default.
• W4220763457 cites W3083166201 @default.
• W4220763457 cites W3091806149 @default.
• W4220763457 cites W3095682799 @default.
• W4220763457 cites W3096390470 @default.
• W4220763457 cites W3096875329 @default.
• W4220763457 cites W3106961537 @default.
• W4220763457 cites W3108294928 @default.
• W4220763457 cites W3111876889 @default.
• W4220763457 cites W3112004952 @default.
• W4220763457 doi "https://doi.org/10.2174/1871520622666220324100510" @default.
• W4220763457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35331099" @default.
• W4220763457 hasPublicationYear "2023" @default.
• W4220763457 type Work @default.
• W4220763457 citedByCount "2" @default.
• W4220763457 countsByYear W42207634572022 @default.
• W4220763457 countsByYear W42207634572023 @default.
• W4220763457 crossrefType "journal-article" @default.
• W4220763457 hasAuthorship W4220763457A5012677271 @default.
• W4220763457 hasAuthorship W4220763457A5039913914 @default.
• W4220763457 hasAuthorship W4220763457A5043667195 @default.
• W4220763457 hasAuthorship W4220763457A5087052969 @default.
• W4220763457 hasConcept C121608353 @default.
• W4220763457 hasConcept C153911025 @default.
• W4220763457 hasConcept C158617107 @default.
• W4220763457 hasConcept C170493617 @default.
• W4220763457 hasConcept C185592680 @default.
• W4220763457 hasConcept C190283241 @default.
• W4220763457 hasConcept C2777209026 @default.
• W4220763457 hasConcept C502942594 @default.
• W4220763457 hasConcept C53227056 @default.
• W4220763457 hasConcept C54355233 @default.
• W4220763457 hasConcept C55493867 @default.
• W4220763457 hasConcept C57074206 @default.
• W4220763457 hasConcept C62112901 @default.
• W4220763457 hasConcept C62478195 @default.
• W4220763457 hasConcept C86803240 @default.
• W4220763457 hasConcept C95444343 @default.
• W4220763457 hasConcept C96232424 @default.
• W4220763457 hasConceptScore W4220763457C121608353 @default.
• W4220763457 hasConceptScore W4220763457C153911025 @default.
• W4220763457 hasConceptScore W4220763457C158617107 @default.
• W4220763457 hasConceptScore W4220763457C170493617 @default.
• W4220763457 hasConceptScore W4220763457C185592680 @default.
• W4220763457 hasConceptScore W4220763457C190283241 @default.
• W4220763457 hasConceptScore W4220763457C2777209026 @default.
• W4220763457 hasConceptScore W4220763457C502942594 @default.
• W4220763457 hasConceptScore W4220763457C53227056 @default.
• W4220763457 hasConceptScore W4220763457C54355233 @default.
• W4220763457 hasConceptScore W4220763457C55493867 @default.
• W4220763457 hasConceptScore W4220763457C57074206 @default.
• W4220763457 hasConceptScore W4220763457C62112901 @default.
• W4220763457 hasConceptScore W4220763457C62478195 @default.
• W4220763457 hasConceptScore W4220763457C86803240 @default.
• W4220763457 hasConceptScore W4220763457C95444343 @default.
• W4220763457 hasConceptScore W4220763457C96232424 @default.
• W4220763457 hasIssue "3" @default.
• W4220763457 hasLocation W42207634571 @default.
• W4220763457 hasLocation W42207634572 @default.

• next