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• W4220763834 startingPage "e13159" @default.
• W4220763834 abstract "Background Bronchoalveolar lavage fluid (BALF) exosomes possess different properties in different diseases, which are mediated through microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), among others. By sequencing the differentially expressed lncRNAs in BALF exosomes, we seek potential targets for the diagnosis and treatment of acute lung injury (ALI). Methods Considering that human and rat genes are about 80% similar, ALI was induced using lipopolysaccharide in six male Wistar rats, with six rats as control (all weighing 200 ± 20 g and aged 6–8 weeks). BALF exosomes were obtained 24 h after ALI. The exosomes in BALF were extracted by ultracentrifugation. The differential expression of BALF exosomal lncRNAs in BALF was analyzed by RNA sequencing. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to predict the functions of differentially expressed lncRNAs, which were confirmed by reverse transcription–polymerase chain reaction. Results Compared with the control group, the ALI group displayed a higher wet/dry ratio, tumor necrosis factor-α levels, and interleukin-6 levels (all P < 0.001). The airway injection of exosomes in rats led to significant infiltration by neutrophils. A total of 2,958 differentially expressed exosomal lncRNAs were identified, including 2,524 upregulated and 434 downregulated ones. Five lncRNAs confirmed the reliability of the sequencing data. The top three GO functions were phagocytic vesicle membrane, regulation of receptor biosynthesis process, and I-SMAD binding. Salmonella infection, Toll-like receptor signaling pathway, and osteoclast differentiation were the most enriched KEGG pathways. The lncRNA–miRNA interaction network of the five confirmed lncRNAs could be predicted using miRDB. Conclusions BALF-derived exosomes play an important role in ALI development and help identify potential therapeutic targets related to ALI." @default.
• W4220763834 created "2022-04-03" @default.
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• W4220763834 date "2022-03-30" @default.
• W4220763834 modified "2023-09-28" @default.
• W4220763834 title "RNA sequencing reveals the emerging role of bronchoalveolar lavage fluid exosome lncRNAs in acute lung injury" @default.
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• W4220763834 cites W1832220924 @default.
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• W4220763834 cites W1976089840 @default.
• W4220763834 cites W1986321004 @default.
• W4220763834 cites W2007323336 @default.
• W4220763834 cites W2008906556 @default.
• W4220763834 cites W2011376139 @default.
• W4220763834 cites W2072063027 @default.
• W4220763834 cites W2076102211 @default.
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• W4220763834 cites W2104005232 @default.
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• W4220763834 cites W2121882633 @default.
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• W4220763834 cites W2144371152 @default.
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• W4220763834 cites W2549542099 @default.
• W4220763834 cites W2580923867 @default.
• W4220763834 cites W2600094664 @default.
• W4220763834 cites W2780260597 @default.
• W4220763834 cites W2793697171 @default.
• W4220763834 cites W2804555310 @default.
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• W4220763834 cites W2898749924 @default.
• W4220763834 cites W2900756811 @default.
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• W4220763834 cites W2913635964 @default.
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• W4220763834 doi "https://doi.org/10.7717/peerj.13159" @default.
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