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- W4220766314 endingPage "100012" @default.
- W4220766314 startingPage "100012" @default.
- W4220766314 abstract "Cocaine use disorder (CUD) is a significant public health issue that generates substantial personal, familial, and economic burdens. Still, there are no FDA-approved pharmacotherapies for CUD. Cocaine-dependent individuals report anxiety during withdrawal, and alleviation of anxiety and other negative affective states may be critical for maintaining drug abstinence. However, the neurobiological mechanisms underlying abstinence-related anxiety in humans or anxiety-like behavior in rodents are not fully understood. This review summarizes investigations regarding anxiety-like behavior in mice and rats undergoing cocaine abstinence, as assessed using four of the most common anxiety-related assays: the elevated plus (or its derivative, the elevated zero) maze, open field test, light-dark transition test, and defensive burying task. We first summarize available evidence that cocaine abstinence generates anxiety-like behavior that persists throughout protracted abstinence. Then, we examine investigations concerning neuropeptide, neurotransmitter, and neuromodulator systems in cocaine abstinence-induced anxiety-like behavior. Throughout, we discuss how differences in sex, rodent strain, cocaine dose and dosing strategy, and abstinence duration interact to generate anxiety-like behavior." @default.
- W4220766314 created "2022-04-03" @default.
- W4220766314 creator A5062045407 @default.
- W4220766314 creator A5081108799 @default.
- W4220766314 date "2022-06-01" @default.
- W4220766314 modified "2023-09-25" @default.
- W4220766314 title "Brain systems in cocaine abstinence-induced anxiety-like behavior in rodents: A review" @default.
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