Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220766577> ?p ?o ?g. }
- W4220766577 abstract "We present a droplet-based microfluidic system that enables CRISPR-based gene editing and high-throughput screening on a chip. The microfluidic device contains a 10 × 10 element array, and each element contains sets of electrodes for two electric field-actuated operations: electrowetting for merging droplets to mix reagents and electroporation for transformation. This device can perform up to 100 genetic modification reactions in parallel, providing a scalable platform for generating the large number of engineered strains required for the combinatorial optimization of genetic pathways and predictable bioengineering. We demonstrate the system's capabilities through the CRISPR-based engineering of two test cases: (1) disruption of the function of the enzyme galactokinase (galK) in E. coli and (2) targeted engineering of the glutamine synthetase gene (glnA) and the blue-pigment synthetase gene (bpsA) to improve indigoidine production in E. coli." @default.
- W4220766577 created "2022-04-03" @default.
- W4220766577 creator A5000005456 @default.
- W4220766577 creator A5003905928 @default.
- W4220766577 creator A5021331494 @default.
- W4220766577 creator A5027915011 @default.
- W4220766577 creator A5029105964 @default.
- W4220766577 creator A5037693308 @default.
- W4220766577 creator A5039361820 @default.
- W4220766577 creator A5041375274 @default.
- W4220766577 creator A5063377086 @default.
- W4220766577 creator A5063703987 @default.
- W4220766577 creator A5064016356 @default.
- W4220766577 creator A5082182460 @default.
- W4220766577 creator A5087233738 @default.
- W4220766577 creator A5088204645 @default.
- W4220766577 date "2022-03-15" @default.
- W4220766577 modified "2023-10-17" @default.
- W4220766577 title "Scalable and automated CRISPR-based strain engineering using droplet microfluidics" @default.
- W4220766577 cites W2019309036 @default.
- W4220766577 cites W2035724688 @default.
- W4220766577 cites W2087704167 @default.
- W4220766577 cites W2136636278 @default.
- W4220766577 cites W2136670217 @default.
- W4220766577 cites W2144779133 @default.
- W4220766577 cites W2147876420 @default.
- W4220766577 cites W2152603063 @default.
- W4220766577 cites W2158592422 @default.
- W4220766577 cites W2179348438 @default.
- W4220766577 cites W2273981063 @default.
- W4220766577 cites W2315037768 @default.
- W4220766577 cites W2340041357 @default.
- W4220766577 cites W2409273107 @default.
- W4220766577 cites W2417788712 @default.
- W4220766577 cites W2559860295 @default.
- W4220766577 cites W2565169990 @default.
- W4220766577 cites W2568559398 @default.
- W4220766577 cites W2585573161 @default.
- W4220766577 cites W2618242435 @default.
- W4220766577 cites W2744412447 @default.
- W4220766577 cites W2793957704 @default.
- W4220766577 cites W2798810874 @default.
- W4220766577 cites W2803046229 @default.
- W4220766577 cites W2892747992 @default.
- W4220766577 cites W2921963218 @default.
- W4220766577 cites W2947525773 @default.
- W4220766577 cites W3024236153 @default.
- W4220766577 cites W3088231826 @default.
- W4220766577 cites W4210960748 @default.
- W4220766577 doi "https://doi.org/10.1038/s41378-022-00357-3" @default.
- W4220766577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35359611" @default.
- W4220766577 hasPublicationYear "2022" @default.
- W4220766577 type Work @default.
- W4220766577 citedByCount "6" @default.
- W4220766577 countsByYear W42207665772022 @default.
- W4220766577 countsByYear W42207665772023 @default.
- W4220766577 crossrefType "journal-article" @default.
- W4220766577 hasAuthorship W4220766577A5000005456 @default.
- W4220766577 hasAuthorship W4220766577A5003905928 @default.
- W4220766577 hasAuthorship W4220766577A5021331494 @default.
- W4220766577 hasAuthorship W4220766577A5027915011 @default.
- W4220766577 hasAuthorship W4220766577A5029105964 @default.
- W4220766577 hasAuthorship W4220766577A5037693308 @default.
- W4220766577 hasAuthorship W4220766577A5039361820 @default.
- W4220766577 hasAuthorship W4220766577A5041375274 @default.
- W4220766577 hasAuthorship W4220766577A5063377086 @default.
- W4220766577 hasAuthorship W4220766577A5063703987 @default.
- W4220766577 hasAuthorship W4220766577A5064016356 @default.
- W4220766577 hasAuthorship W4220766577A5082182460 @default.
- W4220766577 hasAuthorship W4220766577A5087233738 @default.
- W4220766577 hasAuthorship W4220766577A5088204645 @default.
- W4220766577 hasBestOaLocation W42207665771 @default.
- W4220766577 hasConcept C104317684 @default.
- W4220766577 hasConcept C133386390 @default.
- W4220766577 hasConcept C138942068 @default.
- W4220766577 hasConcept C144501496 @default.
- W4220766577 hasConcept C171250308 @default.
- W4220766577 hasConcept C186852380 @default.
- W4220766577 hasConcept C191908910 @default.
- W4220766577 hasConcept C192562407 @default.
- W4220766577 hasConcept C2779673822 @default.
- W4220766577 hasConcept C41008148 @default.
- W4220766577 hasConcept C48044578 @default.
- W4220766577 hasConcept C49040817 @default.
- W4220766577 hasConcept C54355233 @default.
- W4220766577 hasConcept C70721500 @default.
- W4220766577 hasConcept C77088390 @default.
- W4220766577 hasConcept C8673954 @default.
- W4220766577 hasConcept C86803240 @default.
- W4220766577 hasConcept C92444450 @default.
- W4220766577 hasConcept C98108389 @default.
- W4220766577 hasConceptScore W4220766577C104317684 @default.
- W4220766577 hasConceptScore W4220766577C133386390 @default.
- W4220766577 hasConceptScore W4220766577C138942068 @default.
- W4220766577 hasConceptScore W4220766577C144501496 @default.
- W4220766577 hasConceptScore W4220766577C171250308 @default.
- W4220766577 hasConceptScore W4220766577C186852380 @default.
- W4220766577 hasConceptScore W4220766577C191908910 @default.
- W4220766577 hasConceptScore W4220766577C192562407 @default.
- W4220766577 hasConceptScore W4220766577C2779673822 @default.