Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220771440> ?p ?o ?g. }
- W4220771440 abstract "Epithelial wound healing in Drosophila involves the formation of multinucleate cells surrounding the wound. We show that autophagy, a cellular degradation process often deployed in stress responses, is required for the formation of a multinucleated syncytium during wound healing, and that autophagosomes that appear near the wound edge acquire plasma membrane markers. In addition, uncontrolled autophagy in the unwounded epidermis leads to the degradation of endo-membranes and the lateral plasma membrane, while apical and basal membranes and epithelial barrier function remain intact. Proper functioning of TORC1 is needed to prevent destruction of the larval epidermis by autophagy, in a process that depends on phagophore initiation and expansion but does not require autophagosomes fusion with lysosomes. Autophagy induction can also affect other sub-cellular membranes, as shown by its suppression of experimentally induced laminopathy-like nuclear defects. Our findings reveal a function for TORC1-mediated regulation of autophagy in maintaining membrane integrity and homeostasis in the epidermis and during wound healing." @default.
- W4220771440 created "2022-04-03" @default.
- W4220771440 creator A5012787334 @default.
- W4220771440 creator A5027425710 @default.
- W4220771440 creator A5056190515 @default.
- W4220771440 creator A5090932782 @default.
- W4220771440 date "2022-03-09" @default.
- W4220771440 modified "2023-09-24" @default.
- W4220771440 title "Autophagy–mediated plasma membrane removal promotes the formation of epithelial syncytia" @default.
- W4220771440 cites W1513811335 @default.
- W4220771440 cites W1563879817 @default.
- W4220771440 cites W1579748532 @default.
- W4220771440 cites W1828486192 @default.
- W4220771440 cites W1855321011 @default.
- W4220771440 cites W1939431494 @default.
- W4220771440 cites W1961449438 @default.
- W4220771440 cites W1968255867 @default.
- W4220771440 cites W1969967829 @default.
- W4220771440 cites W1970706402 @default.
- W4220771440 cites W1977167726 @default.
- W4220771440 cites W1987467930 @default.
- W4220771440 cites W1987817703 @default.
- W4220771440 cites W1990992599 @default.
- W4220771440 cites W1996858055 @default.
- W4220771440 cites W2004910827 @default.
- W4220771440 cites W2006148298 @default.
- W4220771440 cites W2006229889 @default.
- W4220771440 cites W2012178564 @default.
- W4220771440 cites W2023784682 @default.
- W4220771440 cites W2026860604 @default.
- W4220771440 cites W2026896701 @default.
- W4220771440 cites W2029478181 @default.
- W4220771440 cites W2032685334 @default.
- W4220771440 cites W2040377035 @default.
- W4220771440 cites W2046831598 @default.
- W4220771440 cites W2054815464 @default.
- W4220771440 cites W2072810104 @default.
- W4220771440 cites W2079015945 @default.
- W4220771440 cites W2081092282 @default.
- W4220771440 cites W2083919459 @default.
- W4220771440 cites W2085392189 @default.
- W4220771440 cites W2090817340 @default.
- W4220771440 cites W2103046819 @default.
- W4220771440 cites W2110357466 @default.
- W4220771440 cites W2115363971 @default.
- W4220771440 cites W2117257231 @default.
- W4220771440 cites W2118407679 @default.
- W4220771440 cites W2118956678 @default.
- W4220771440 cites W2119591493 @default.
- W4220771440 cites W2122761286 @default.
- W4220771440 cites W2131925550 @default.
- W4220771440 cites W2141639422 @default.
- W4220771440 cites W2142018200 @default.
- W4220771440 cites W2144718635 @default.
- W4220771440 cites W2150972545 @default.
- W4220771440 cites W2160777888 @default.
- W4220771440 cites W2161007406 @default.
- W4220771440 cites W2164998112 @default.
- W4220771440 cites W2167558439 @default.
- W4220771440 cites W2180027722 @default.
- W4220771440 cites W2254380769 @default.
- W4220771440 cites W2314998955 @default.
- W4220771440 cites W2404264686 @default.
- W4220771440 cites W2409211724 @default.
- W4220771440 cites W241332058 @default.
- W4220771440 cites W2466680365 @default.
- W4220771440 cites W2528857537 @default.
- W4220771440 cites W2534312836 @default.
- W4220771440 cites W2560915405 @default.
- W4220771440 cites W2569101386 @default.
- W4220771440 cites W2767606134 @default.
- W4220771440 cites W2788162903 @default.
- W4220771440 cites W2888070055 @default.
- W4220771440 cites W2909477364 @default.
- W4220771440 cites W2979157722 @default.
- W4220771440 cites W2981674725 @default.
- W4220771440 cites W2985847054 @default.
- W4220771440 cites W3002073975 @default.
- W4220771440 cites W3004849989 @default.
- W4220771440 cites W3005187751 @default.
- W4220771440 cites W3006098252 @default.
- W4220771440 cites W3024482355 @default.
- W4220771440 cites W3067364927 @default.
- W4220771440 cites W3081733528 @default.
- W4220771440 cites W3094060348 @default.
- W4220771440 cites W3101766215 @default.
- W4220771440 cites W3106696187 @default.
- W4220771440 cites W3108936441 @default.
- W4220771440 cites W3116546081 @default.
- W4220771440 cites W3118519106 @default.
- W4220771440 cites W3126180845 @default.
- W4220771440 cites W4220771440 @default.
- W4220771440 doi "https://doi.org/10.15252/embj.2021109992" @default.
- W4220771440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35262206" @default.
- W4220771440 hasPublicationYear "2022" @default.
- W4220771440 type Work @default.
- W4220771440 citedByCount "7" @default.
- W4220771440 countsByYear W42207714402022 @default.
- W4220771440 countsByYear W42207714402023 @default.
- W4220771440 crossrefType "journal-article" @default.