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• W4220771657 abstract "Objective. The objective of the study is to investigate the relationships between fetuin-B, thyroid autoimmunity (TAI), and pregnancy outcomes in women undergoing in vitro fertilization and embryo transfer (IVF-ET). Design, Patients, and Measurements. In this prospective study, 180 women who were preparing for pregnancy with IVF-ET were included. There were 120 women with TAI positive and 60 negative controls matched with age and BMI. Results. The 180 women had mean ± SD age of 31.4 ± 4.0 years, with a mean ± SD BMI of 21.0 ± 1.6 kg/m2. There was a significant difference in the level of fetuin-B in women with TAI positive compared with TAI negative group (65.2 ± 18.5 vs. 76.4 ± 25.1, <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo>=</mo> <mn>0.001</mn> </math> ). Fetuin-B had a negative relationship with thyroid antibodies even after adjusting for other variables (OR (95%CI) = 0.98 (0.96–0.99), <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo>=</mo> <mn>0.002</mn> </math> ). Compared with women with TAI negative, those with TAI positive had a significantly higher risk of low fertilization (20.0% vs. 6.7%; <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo>=</mo> <mn>0.035</mn> </math> ). And we found no difference in terms of pregnancy, abortion, implantation, and live birth rate between the two groups. Logistic regression analysis showed that both fetuin-B and TAI were the independent factors to lead the low fertilization of IVF-ET (OR (95%CI) = 0.96 (0.94–0.99) and 4.084 (1.39–15.30), <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo>=</mo> <mn>0.004</mn> </math> and 0.019, respectively). Conclusion. Fetuin-B was significantly associated with TAI and low fertilization rate in women undergoing IVF-ET. Decreased fetuin-B in women with TAI may be the underlying reason for the lower IVF-ET success rate." @default.
• W4220771657 created "2022-04-03" @default.
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• W4220771657 date "2022-03-16" @default.
• W4220771657 modified "2023-10-18" @default.
• W4220771657 title "The Relationships among Plasma Fetuin-B, Thyroid Autoimmunity, and Fertilization Rate In Vitro Fertilization and Embryo Transfer" @default.
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• W4220771657 doi "https://doi.org/10.1155/2022/9961253" @default.
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