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- W4220773969 endingPage "18" @default.
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- W4220773969 abstract "Idiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease (ILD) characterized by the proliferation of fibroblasts and aberrant accumulation of extracellular matrix. These changes are accompanied by structural destruction of the lung tissue and the progressive decline of pulmonary function. In the past few decades, researchers have investigated the pathogenesis of IPF and sought a therapeutic approach for its treatment. Some studies have shown that the occurrence of IPF is related to pulmonary inflammatory injury; however, its specific etiology and pathogenesis remain unknown, and no effective treatment, with the exception of lung transplantation, has been identified yet. Several basic science and clinical studies in recent years have shown that statins, the traditional lipid-lowering drugs, exert significant antifibrotic effects, which can delay the progression of IPF and impairment of pulmonary function. This article is aimed at summarizing the current understanding of the pathogenesis of IPF, the progress of research on the use of statins in IPF models and clinical trials, and its main molecular targets." @default.
- W4220773969 created "2022-04-03" @default.
- W4220773969 creator A5015488433 @default.
- W4220773969 creator A5019488428 @default.
- W4220773969 creator A5034126692 @default.
- W4220773969 creator A5044990630 @default.
- W4220773969 date "2022-03-19" @default.
- W4220773969 modified "2023-09-26" @default.
- W4220773969 title "Progress of Statin Therapy in the Treatment of Idiopathic Pulmonary Fibrosis" @default.
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