Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220774582> ?p ?o ?g. }
- W4220774582 endingPage "156" @default.
- W4220774582 startingPage "149" @default.
- W4220774582 abstract "Four bioactive metabolites; ergosterol (1), peroxy ergosterol (2), α-cyclopiazonic acid (3) and kojic acid (4), were isolated from the fungal sp. Trichoderma viride MM21. Their structures were assigned by cumulative analysis of NMR and mass spectra, and comparison with literature. The antimicrobial activity of the fungus supernatant, mycelial cake, cumulative crude extract and compounds 1-4 was broadly studied against 11 diverse pathogens, revealing auspicious activity results. Based on the molecular docking, ergosterol (1) and peroxy ergosterol (2) were picked up to be computationally tested against topoisomerase IV of Staphylococcus aureus. The nominated enzyme is a possible target for the antibacterial activity of triterpenoidal/steroidal compounds. Compounds 1, 2 showed a deep inserting inside the enzyme groove recording a good binding affinity of -8.1 and -8.4 kcal/mol, respectively. Noteworthy that the antibacterial activity of ergosterol was higher (14-17 mm) than peroxy ergosterol (11-14 mm), although ergosterol formed only one hydrogen bond with the target, while peroxy ergosterol formed three hydrogen bonds. Such higher antibacterial activity of ergosterol may be attributed to its interference with other proteins included in this inhibition. The cytotoxic activity was tested against brine shrimp, revealing 100% mortality for the supernatant, crude extract and whole isolated compounds. Such strong cytotoxicity is attributed most likely to the abundant productivity/concentration of α-cyclopiazonic acid and kojic acid." @default.
- W4220774582 created "2022-04-03" @default.
- W4220774582 creator A5024763484 @default.
- W4220774582 creator A5037555944 @default.
- W4220774582 creator A5042691029 @default.
- W4220774582 creator A5047557653 @default.
- W4220774582 creator A5087161395 @default.
- W4220774582 creator A5090814120 @default.
- W4220774582 date "2022-03-18" @default.
- W4220774582 modified "2023-10-16" @default.
- W4220774582 title "Bioactive secondary metabolites from <i>Trichoderma viride</i> MM21: structure elucidation, molecular docking and biological activity" @default.
- W4220774582 cites W1225540146 @default.
- W4220774582 cites W1971981678 @default.
- W4220774582 cites W1998602558 @default.
- W4220774582 cites W2000101935 @default.
- W4220774582 cites W2007669310 @default.
- W4220774582 cites W2015851647 @default.
- W4220774582 cites W2018887064 @default.
- W4220774582 cites W2032925467 @default.
- W4220774582 cites W2036495687 @default.
- W4220774582 cites W2045489663 @default.
- W4220774582 cites W2049729243 @default.
- W4220774582 cites W2058590007 @default.
- W4220774582 cites W2064099810 @default.
- W4220774582 cites W2074079991 @default.
- W4220774582 cites W2090400653 @default.
- W4220774582 cites W2093961165 @default.
- W4220774582 cites W2095449241 @default.
- W4220774582 cites W2101504620 @default.
- W4220774582 cites W2108638835 @default.
- W4220774582 cites W2111936210 @default.
- W4220774582 cites W2114423667 @default.
- W4220774582 cites W2117621493 @default.
- W4220774582 cites W2130466938 @default.
- W4220774582 cites W2133173059 @default.
- W4220774582 cites W2134491693 @default.
- W4220774582 cites W2134967712 @default.
- W4220774582 cites W2147682062 @default.
- W4220774582 cites W2192234239 @default.
- W4220774582 cites W2203962955 @default.
- W4220774582 cites W2529920144 @default.
- W4220774582 cites W2782916169 @default.
- W4220774582 cites W2796260470 @default.
- W4220774582 cites W2803450140 @default.
- W4220774582 cites W2903589524 @default.
- W4220774582 cites W2904282263 @default.
- W4220774582 cites W2946412700 @default.
- W4220774582 cites W2951254233 @default.
- W4220774582 cites W2952922249 @default.
- W4220774582 cites W3021075316 @default.
- W4220774582 cites W3114115955 @default.
- W4220774582 cites W316501679 @default.
- W4220774582 cites W3177940451 @default.
- W4220774582 cites W4240382156 @default.
- W4220774582 cites W4322701634 @default.
- W4220774582 doi "https://doi.org/10.1515/znc-2021-0284" @default.
- W4220774582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35304839" @default.
- W4220774582 hasPublicationYear "2022" @default.
- W4220774582 type Work @default.
- W4220774582 citedByCount "0" @default.
- W4220774582 crossrefType "journal-article" @default.
- W4220774582 hasAuthorship W4220774582A5024763484 @default.
- W4220774582 hasAuthorship W4220774582A5037555944 @default.
- W4220774582 hasAuthorship W4220774582A5042691029 @default.
- W4220774582 hasAuthorship W4220774582A5047557653 @default.
- W4220774582 hasAuthorship W4220774582A5087161395 @default.
- W4220774582 hasAuthorship W4220774582A5090814120 @default.
- W4220774582 hasConcept C178790620 @default.
- W4220774582 hasConcept C181199279 @default.
- W4220774582 hasConcept C185592680 @default.
- W4220774582 hasConcept C2777910421 @default.
- W4220774582 hasConcept C2779538156 @default.
- W4220774582 hasConcept C2780052172 @default.
- W4220774582 hasConcept C2780104969 @default.
- W4220774582 hasConcept C31903555 @default.
- W4220774582 hasConcept C4937899 @default.
- W4220774582 hasConcept C523546767 @default.
- W4220774582 hasConcept C54355233 @default.
- W4220774582 hasConcept C55493867 @default.
- W4220774582 hasConcept C71240020 @default.
- W4220774582 hasConcept C86803240 @default.
- W4220774582 hasConcept C87554066 @default.
- W4220774582 hasConceptScore W4220774582C178790620 @default.
- W4220774582 hasConceptScore W4220774582C181199279 @default.
- W4220774582 hasConceptScore W4220774582C185592680 @default.
- W4220774582 hasConceptScore W4220774582C2777910421 @default.
- W4220774582 hasConceptScore W4220774582C2779538156 @default.
- W4220774582 hasConceptScore W4220774582C2780052172 @default.
- W4220774582 hasConceptScore W4220774582C2780104969 @default.
- W4220774582 hasConceptScore W4220774582C31903555 @default.
- W4220774582 hasConceptScore W4220774582C4937899 @default.
- W4220774582 hasConceptScore W4220774582C523546767 @default.
- W4220774582 hasConceptScore W4220774582C54355233 @default.
- W4220774582 hasConceptScore W4220774582C55493867 @default.
- W4220774582 hasConceptScore W4220774582C71240020 @default.
- W4220774582 hasConceptScore W4220774582C86803240 @default.
- W4220774582 hasConceptScore W4220774582C87554066 @default.
- W4220774582 hasIssue "3-4" @default.