FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220774992> ?p ?o ?g. }

• W4220774992 abstract "Schizophrenia is a chronic and severe mental disorder. Dysregulated decision-making and affective processing have been implicated in patients with schizophrenia (SZ) and have significant impacts on their cognitive and social functions. However, little is known about how affective arousal influences reward-based decision-making in SZ. Taking advantage of a two-choice probabilistic gambling task and utilizing three facial expressions as affective primes (i.e., neutral, angry, and happy conditions) in each trial, we investigated how affective arousal influences reward-related choice based on behavioral, model fitting, and feedback-related negativity (FRN) data in 38 SZ and 26 healthy controls (CTRL). We also correlated our measurements with patients' symptom severity. Compared with the CTRL group, SZ expressed blunted responses to angry facial primes. They had lower total game scores and displayed more maladaptive choice strategies (i.e., less win-stay and more lose-shift) and errors in monitoring rewards. Model fitting results revealed that the SZ group had a higher learning rate and lower choice consistency, especially in the happy condition. Brain activity data further indicated that SZ had smaller amplitudes of FRN than their controls in the angry and happy conditions. Importantly, the SZ group exhibited attenuated affective influence on decision-making, and their impairments in decision-making were only correlated with their clinical symptoms in the angry condition. Our findings imply the affective processing is dysregulated in SZ and it is selectively involved in the regulation of choice strategies, choice behaviors, and FRN in SZ, which lead to impairments in reward-related decision-making, especially in the angry condition." @default.
• W4220774992 created "2022-04-03" @default.
• W4220774992 creator A5005108843 @default.
• W4220774992 creator A5018201435 @default.
• W4220774992 creator A5052169736 @default.
• W4220774992 creator A5055085721 @default.
• W4220774992 creator A5063850009 @default.
• W4220774992 creator A5078375808 @default.
• W4220774992 date "2022-03-21" @default.
• W4220774992 modified "2023-10-16" @default.
• W4220774992 title "Dysregulated affective arousal regulates reward-based decision making in patients with schizophrenia: an integrated study" @default.
• W4220774992 cites W1517555081 @default.
• W4220774992 cites W1518408905 @default.
• W4220774992 cites W1955614066 @default.
• W4220774992 cites W1965146231 @default.
• W4220774992 cites W1969251217 @default.
• W4220774992 cites W1974110307 @default.
• W4220774992 cites W1974713132 @default.
• W4220774992 cites W1977924236 @default.
• W4220774992 cites W1979025384 @default.
• W4220774992 cites W1988775970 @default.
• W4220774992 cites W1990191307 @default.
• W4220774992 cites W1990592342 @default.
• W4220774992 cites W1992997294 @default.
• W4220774992 cites W1994022122 @default.
• W4220774992 cites W1999387961 @default.
• W4220774992 cites W2001795509 @default.
• W4220774992 cites W2002790098 @default.
• W4220774992 cites W2015770890 @default.
• W4220774992 cites W2022775357 @default.
• W4220774992 cites W2049865797 @default.
• W4220774992 cites W2052161329 @default.
• W4220774992 cites W2058188943 @default.
• W4220774992 cites W2066492582 @default.
• W4220774992 cites W2073806182 @default.
• W4220774992 cites W2082088355 @default.
• W4220774992 cites W2084331056 @default.
• W4220774992 cites W2084711871 @default.
• W4220774992 cites W2087251764 @default.
• W4220774992 cites W2088183125 @default.
• W4220774992 cites W2107726111 @default.
• W4220774992 cites W2108602008 @default.
• W4220774992 cites W2112380861 @default.
• W4220774992 cites W2114390994 @default.
• W4220774992 cites W2114512489 @default.
• W4220774992 cites W2117726420 @default.
• W4220774992 cites W2119052627 @default.
• W4220774992 cites W2125015303 @default.
• W4220774992 cites W2132073746 @default.
• W4220774992 cites W2132218777 @default.
• W4220774992 cites W2133788626 @default.
• W4220774992 cites W2135572147 @default.
• W4220774992 cites W2137125240 @default.
• W4220774992 cites W2140487181 @default.
• W4220774992 cites W2140606211 @default.
• W4220774992 cites W2142258740 @default.
• W4220774992 cites W2145602532 @default.
• W4220774992 cites W2148905283 @default.
• W4220774992 cites W2149221657 @default.
• W4220774992 cites W2150983377 @default.
• W4220774992 cites W2155167336 @default.
• W4220774992 cites W2156156415 @default.
• W4220774992 cites W2161689902 @default.
• W4220774992 cites W2165525034 @default.
• W4220774992 cites W2168648143 @default.
• W4220774992 cites W2170605051 @default.
• W4220774992 cites W2171441239 @default.
• W4220774992 cites W2260986243 @default.
• W4220774992 cites W2261385605 @default.
• W4220774992 cites W2327773496 @default.
• W4220774992 cites W2400340781 @default.
• W4220774992 cites W2505804705 @default.
• W4220774992 cites W2518844890 @default.
• W4220774992 cites W2526947450 @default.
• W4220774992 cites W2803735852 @default.
• W4220774992 cites W2885941492 @default.
• W4220774992 cites W3014036292 @default.
• W4220774992 cites W3181936035 @default.
• W4220774992 cites W4231324690 @default.
• W4220774992 cites W4292994367 @default.
• W4220774992 doi "https://doi.org/10.1038/s41537-022-00234-y" @default.
• W4220774992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35314840" @default.
• W4220774992 hasPublicationYear "2022" @default.
• W4220774992 type Work @default.
• W4220774992 citedByCount "1" @default.
• W4220774992 countsByYear W42207749922023 @default.
• W4220774992 crossrefType "journal-article" @default.
• W4220774992 hasAuthorship W4220774992A5005108843 @default.
• W4220774992 hasAuthorship W4220774992A5018201435 @default.
• W4220774992 hasAuthorship W4220774992A5052169736 @default.
• W4220774992 hasAuthorship W4220774992A5055085721 @default.
• W4220774992 hasAuthorship W4220774992A5063850009 @default.
• W4220774992 hasAuthorship W4220774992A5078375808 @default.
• W4220774992 hasBestOaLocation W42207749921 @default.
• W4220774992 hasConcept C118552586 @default.
• W4220774992 hasConcept C138496976 @default.
• W4220774992 hasConcept C15744967 @default.
• W4220774992 hasConcept C169760540 @default.
• W4220774992 hasConcept C169900460 @default.
• W4220774992 hasConcept C180747234 @default.

• next