Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220776985> ?p ?o ?g. }
- W4220776985 endingPage "2028" @default.
- W4220776985 startingPage "1983" @default.
- W4220776985 abstract "ABSTRACT: The discovery of antibiotics was a revolutionary feat that provided countless health bene-fits. The identification of penicillin by Alexander Fleming initiated the era of antibiotics, represent-ed by constant discoveries that enabled effective treatments for the different classes of diseases caused by bacteria. However, the indiscriminate use of these drugs allowed the emergence of re-sistance mechanisms of these microorganisms against the available drugs. In addition, the constant discoveries in the 20th century generated a shortage of new molecules, worrying health agencies and professionals about the appearance of multidrug-resistant strains against available drugs. In this context, the advances of recent years in molecular biology and microbiology have allowed new per-spectives in drug design and development, using the findings related to the mechanisms of bacterial resistance to generate new drugs that are not affected by such mechanisms and supply new mole-cules to be used to treat resistant bacterial infections. Besides, a promising strategy against bacterial resistance is the combination of drugs through adjuvants, providing new expectations in designing new antibiotics and new antimicrobial therapies. Thus, this manuscript will address the main mech-anisms of bacterial resistance under the understanding of medicinal chemistry, showing the main active compounds against efflux mechanisms, and also the application of the use of drug delivery systems, and finally, the main potential natural products as adjuvants or with promising activity against resistant strains." @default.
- W4220776985 created "2022-04-03" @default.
- W4220776985 creator A5004680385 @default.
- W4220776985 creator A5033055915 @default.
- W4220776985 creator A5045328085 @default.
- W4220776985 creator A5051878782 @default.
- W4220776985 creator A5067791299 @default.
- W4220776985 creator A5073848646 @default.
- W4220776985 creator A5078473675 @default.
- W4220776985 date "2022-09-01" @default.
- W4220776985 modified "2023-09-25" @default.
- W4220776985 title "Medicinal Chemistry of Inhibitors Targeting Resistant Bacteria" @default.
- W4220776985 cites W1488950745 @default.
- W4220776985 cites W1499482268 @default.
- W4220776985 cites W1502497970 @default.
- W4220776985 cites W1512234863 @default.
- W4220776985 cites W1539821149 @default.
- W4220776985 cites W1573067122 @default.
- W4220776985 cites W1576277845 @default.
- W4220776985 cites W1592601208 @default.
- W4220776985 cites W1598136901 @default.
- W4220776985 cites W1607506205 @default.
- W4220776985 cites W1685574292 @default.
- W4220776985 cites W1697048736 @default.
- W4220776985 cites W1840805957 @default.
- W4220776985 cites W1874122563 @default.
- W4220776985 cites W1896929128 @default.
- W4220776985 cites W1913970538 @default.
- W4220776985 cites W1915856409 @default.
- W4220776985 cites W1917256276 @default.
- W4220776985 cites W1926375223 @default.
- W4220776985 cites W1963989891 @default.
- W4220776985 cites W1965451682 @default.
- W4220776985 cites W1968053930 @default.
- W4220776985 cites W1968701741 @default.
- W4220776985 cites W1968833213 @default.
- W4220776985 cites W1968965739 @default.
- W4220776985 cites W1969493831 @default.
- W4220776985 cites W1970415429 @default.
- W4220776985 cites W1970546677 @default.
- W4220776985 cites W1971121351 @default.
- W4220776985 cites W1972111977 @default.
- W4220776985 cites W1972570655 @default.
- W4220776985 cites W1972605876 @default.
- W4220776985 cites W1973268169 @default.
- W4220776985 cites W1974063025 @default.
- W4220776985 cites W1975711556 @default.
- W4220776985 cites W1975780688 @default.
- W4220776985 cites W1978917736 @default.
- W4220776985 cites W1980526754 @default.
- W4220776985 cites W1980655272 @default.
- W4220776985 cites W1983784984 @default.
- W4220776985 cites W1984464901 @default.
- W4220776985 cites W1985108480 @default.
- W4220776985 cites W1985372050 @default.
- W4220776985 cites W1985716049 @default.
- W4220776985 cites W1986481619 @default.
- W4220776985 cites W1988770237 @default.
- W4220776985 cites W1990337211 @default.
- W4220776985 cites W1990835199 @default.
- W4220776985 cites W1992748055 @default.
- W4220776985 cites W1992928036 @default.
- W4220776985 cites W1994300126 @default.
- W4220776985 cites W1994863517 @default.
- W4220776985 cites W1996108021 @default.
- W4220776985 cites W1998644752 @default.
- W4220776985 cites W1998915382 @default.
- W4220776985 cites W2000572336 @default.
- W4220776985 cites W2001166652 @default.
- W4220776985 cites W2001330064 @default.
- W4220776985 cites W2002865102 @default.
- W4220776985 cites W2006648060 @default.
- W4220776985 cites W2007575182 @default.
- W4220776985 cites W2007577762 @default.
- W4220776985 cites W2007599867 @default.
- W4220776985 cites W2007995861 @default.
- W4220776985 cites W2009786701 @default.
- W4220776985 cites W2009933778 @default.
- W4220776985 cites W2011917728 @default.
- W4220776985 cites W2012550584 @default.
- W4220776985 cites W2015178572 @default.
- W4220776985 cites W2015349964 @default.
- W4220776985 cites W2015721897 @default.
- W4220776985 cites W2016173546 @default.
- W4220776985 cites W2016752655 @default.
- W4220776985 cites W2023742594 @default.
- W4220776985 cites W2025067031 @default.
- W4220776985 cites W2025126892 @default.
- W4220776985 cites W2025240035 @default.
- W4220776985 cites W2026374625 @default.
- W4220776985 cites W2027340393 @default.
- W4220776985 cites W2027433336 @default.
- W4220776985 cites W2030831690 @default.
- W4220776985 cites W2034624108 @default.
- W4220776985 cites W2035900467 @default.
- W4220776985 cites W2039458881 @default.
- W4220776985 cites W2042885230 @default.
- W4220776985 cites W2044607163 @default.