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• W4220777773 abstract "Tissues present differences in their metabolism, prioritizing certain metabolic pathways over others. This chapter describes these differences. Liver . all metabolic pathways for glucose, triacylglycerols, phospholipid, cholesterol, ketone bodies, and protein synthesis are active. Glucose is metabolized by converting it to G-6-P by glucokinase when glycemia increases. Fatty acids, subjected to β-oxidation, constitute the main energy source. The liver synthesizes triacylglycerols, phospholipids, and cholesterol; it also forms ketone bodies but cannot use them. The liver is rich in aminotransferases and glutamate dehydrogenase; it is the organ where urea is formed. In addition, the gluconeogenesis pathway is very active. The liver is important in ethanol metabolism , converting it to active acetate, which can follow several pathways, including its final oxidation to CO 2 and H 2 O in the citric acid cycle. The liver is also involved in the biotransformation or detoxification of xenobiotics. Skeletal muscle . Metabolism varies depending on the type of work performed. Intense exercise can be carried out via anaerobic metabolism and the breakdown of muscle glycogen to produce lactate. Low-intensity exercise of short time duration requires the oxidation of fatty acids. Muscle also uses ketoacids from branched-chain amino acids as an energy source. H eart. Due to its continuous activity, the heart generates energy aerobically. It uses fatty acids as the main fuel, but glucose, ketone bodies, and lactate are also oxidized. Adipose tissue represents the major energy reserve of the body; it actively synthesizes triacylglycerols (TAG). The main pathways for G-6-P in fat are glycolysis and pentose phosphate. Lipolysis is catalyzed by lipase. The c entral nervous system uses only glucose as an energy source, consuming ~ 20% of the total O 2 used by the body at rest. Under conditions of prolonged fasting, the brain can also oxidize ketone bodies." @default.
• W4220777773 created "2022-04-03" @default.
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• W4220777773 date "2022-01-01" @default.
• W4220777773 modified "2023-10-02" @default.
• W4220777773 title "Metabolism in some tissues" @default.
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• W4220777773 doi "https://doi.org/10.1016/b978-0-323-91599-1.00012-2" @default.
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