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- W4220777921 abstract "Glioblastoma (GBM) is a highly fatal and recurrent brain cancer without a complete prevailing remedy. Although the synthetic nanotechnology-based approaches exhibit excellent therapeutic potential, the associated cytotoxic effects and organ clearance failure rest major obstacles from bench to clinics. Here, we explored allogeneic bone marrow mesenchymal stem cells isolated exosomes (BMSCExo) decorated with heme oxygenase-1 (HMOX1) specific short peptide (HSSP) as temozolomide (TMZ) and small interfering RNA (siRNA) nanocarrier for TMZ resistant glioblastoma therapy. The BMSCExo had excellent TMZ and siRNA loading ability and could traverse the blood-brain barrier (BBB) by leveraging its intrinsic brain accumulation property. Notably, with HSSP decoration, the TMZ or siRNA encapsulated BMSCExo exhibited excellent TMZ resistant GBM targeting ability both in vitro and in vivo due to the overexpression of HMOX1 in TMZ resistant GBM cells. Further, the HSSP decorated BMSCExo delivered the STAT3 targeted siRNA to the TMZ resistant glioma and restore the TMZ sensitivity, consequently achieved the synergistically drug resistant GBM treatment with TMZ. Our results showed this biomimetic nanoplatform can serve as a flexible, robust and inert system for GBM treatment, especially emphasizing the drug resistant challenge." @default.
- W4220777921 created "2022-04-03" @default.
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- W4220777921 date "2022-05-01" @default.
- W4220777921 modified "2023-10-17" @default.
- W4220777921 title "Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy" @default.
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- W4220777921 cites W2061896947 @default.
- W4220777921 cites W2062165914 @default.
- W4220777921 cites W2066234893 @default.
- W4220777921 cites W2066843867 @default.
- W4220777921 cites W2071625709 @default.
- W4220777921 cites W2078147660 @default.
- W4220777921 cites W2096287682 @default.
- W4220777921 cites W2113089439 @default.
- W4220777921 cites W2137130674 @default.
- W4220777921 cites W2137648328 @default.
- W4220777921 cites W2164762451 @default.
- W4220777921 cites W2205733027 @default.
- W4220777921 cites W2211541075 @default.
- W4220777921 cites W2233124939 @default.
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- W4220777921 cites W2508102725 @default.
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- W4220777921 cites W2913225062 @default.
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- W4220777921 cites W3087992083 @default.
- W4220777921 cites W3092068755 @default.
- W4220777921 cites W3151896258 @default.
- W4220777921 cites W3179599774 @default.
- W4220777921 cites W3196495403 @default.
- W4220777921 cites W3198244112 @default.
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- W4220777921 doi "https://doi.org/10.1016/j.jconrel.2022.03.036" @default.
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