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- W4220778824 abstract "Abstract Evolution turned aquaporins (AQPs) into the most efficient facilitators of passive water flow through cell membranes at no expense of solute discrimination. In spite of a plethora of solved AQP structures, many structural details remain hidden. Here, by combining extensive sequence- and structural-based analysis of a unique set of 20 non-redundant high-resolution structures and molecular dynamics simulations of 4 representatives, we identify key aspects of AQP stability, gating, selectivity, pore geometry and oligomerization, with a potential impact on channel functionality. We challenge the general view of AQPs possessing a continuous open water pore and depict that AQPs selectivity is not exclusively shaped by pore lining residues but also by the relative arrangement of transmembrane helices. Moreover, our analysis reveals that hydrophobic interactions constitute the main determinant of protein thermal stability. Finally, we establish a novel numbering scheme of the conserved AQP scaffold facilitating direct comparison and prediction of potential structural effects of e.g. disease-causing mutations. Additionally, our results pave the way for the design of optimized AQP water channels to be utilized in biotechnological applications." @default.
- W4220778824 created "2022-04-03" @default.
- W4220778824 creator A5000580086 @default.
- W4220778824 creator A5000946042 @default.
- W4220778824 creator A5004764117 @default.
- W4220778824 creator A5012110398 @default.
- W4220778824 creator A5041035239 @default.
- W4220778824 creator A5041992046 @default.
- W4220778824 creator A5055394316 @default.
- W4220778824 date "2022-03-29" @default.
- W4220778824 modified "2023-10-14" @default.
- W4220778824 title "The hidden intricacies of aquaporins: Remarkable details in a common structural scaffold" @default.
- W4220778824 cites W1031578623 @default.
- W4220778824 cites W1502708911 @default.
- W4220778824 cites W1512016817 @default.
- W4220778824 cites W1562378157 @default.
- W4220778824 cites W1580434367 @default.
- W4220778824 cites W1608218663 @default.
- W4220778824 cites W1833104430 @default.
- W4220778824 cites W1931164952 @default.
- W4220778824 cites W1931574707 @default.
- W4220778824 cites W1946394423 @default.
- W4220778824 cites W1947778485 @default.
- W4220778824 cites W1962561849 @default.
- W4220778824 cites W1965956460 @default.
- W4220778824 cites W1974146961 @default.
- W4220778824 cites W1975652298 @default.
- W4220778824 cites W1982230840 @default.
- W4220778824 cites W1984723140 @default.
- W4220778824 cites W1985842673 @default.
- W4220778824 cites W1989707197 @default.
- W4220778824 cites W1990685972 @default.
- W4220778824 cites W1991958052 @default.
- W4220778824 cites W1992310381 @default.
- W4220778824 cites W1992518077 @default.
- W4220778824 cites W1993301962 @default.
- W4220778824 cites W1994525470 @default.
- W4220778824 cites W1995572705 @default.
- W4220778824 cites W1999340580 @default.
- W4220778824 cites W2000282358 @default.
- W4220778824 cites W2002508442 @default.
- W4220778824 cites W2003879331 @default.
- W4220778824 cites W2005546760 @default.
- W4220778824 cites W2009059228 @default.
- W4220778824 cites W2009703891 @default.
- W4220778824 cites W2009843970 @default.
- W4220778824 cites W2009851764 @default.
- W4220778824 cites W2010182284 @default.
- W4220778824 cites W2011357793 @default.
- W4220778824 cites W2011679999 @default.
- W4220778824 cites W2011823820 @default.
- W4220778824 cites W2014301815 @default.
- W4220778824 cites W2015079610 @default.
- W4220778824 cites W2015870127 @default.
- W4220778824 cites W2018768238 @default.
- W4220778824 cites W2020662831 @default.
- W4220778824 cites W2023821031 @default.
- W4220778824 cites W2023979176 @default.
- W4220778824 cites W2024399685 @default.
- W4220778824 cites W2026629384 @default.
- W4220778824 cites W2030119097 @default.
- W4220778824 cites W2032424722 @default.
- W4220778824 cites W2035294304 @default.
- W4220778824 cites W2035503835 @default.
- W4220778824 cites W2041572867 @default.
- W4220778824 cites W2042000969 @default.
- W4220778824 cites W2042458891 @default.
- W4220778824 cites W2043689640 @default.
- W4220778824 cites W2043901383 @default.
- W4220778824 cites W2043996331 @default.
- W4220778824 cites W2048743237 @default.
- W4220778824 cites W2050679273 @default.
- W4220778824 cites W2051425608 @default.
- W4220778824 cites W2051471043 @default.
- W4220778824 cites W2051628563 @default.
- W4220778824 cites W2052038479 @default.
- W4220778824 cites W2052922251 @default.
- W4220778824 cites W2053518734 @default.
- W4220778824 cites W2059149362 @default.
- W4220778824 cites W2060701169 @default.
- W4220778824 cites W2061175110 @default.
- W4220778824 cites W2061718144 @default.
- W4220778824 cites W2065093074 @default.
- W4220778824 cites W2066056753 @default.
- W4220778824 cites W2066414494 @default.
- W4220778824 cites W2067200099 @default.
- W4220778824 cites W2069363866 @default.
- W4220778824 cites W2072292027 @default.
- W4220778824 cites W2078184681 @default.
- W4220778824 cites W2078936885 @default.
- W4220778824 cites W2084168484 @default.
- W4220778824 cites W2084304818 @default.
- W4220778824 cites W2085820729 @default.
- W4220778824 cites W2086007235 @default.
- W4220778824 cites W2086546323 @default.
- W4220778824 cites W2087077288 @default.
- W4220778824 cites W2087637788 @default.
- W4220778824 cites W2089463543 @default.
- W4220778824 cites W2089717693 @default.
- W4220778824 cites W2090082061 @default.