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- W4220778975 abstract "Sweet and umami tastes are elicited by sweet and umami receptors on the tongue and palate epithelium, respectively. However, the molecular machinery allowing the taste reaction remains incompletely understood. Through a phosphoproteomic approach, we identified the key proteins that trigger taste mechanisms based on phosphorylation cascades. Ryanodine receptor isoform 1 (RYR1) was further verified by sensory and behavioral assays. We propose a model of RYR1-mediated sweet/umami signaling in which the RYR1 channel, which mediates Ca2+ release from the endoplasmic reticulum, is closed by dephosphorylation in bud tissue after sweet/umami treatment. The alteration in Ca2+ content in the cytosol induces transient membrane depolarization and generates a cell current for taste signal transduction. We demonstrate that RYR1 is a new channel involved in the regulation of sweet/umami signal transduction and propose a “metabolic clock” notion based on sweet/umami sensing. Our study provides a valuable foundation for a system-level understanding of the taste perception mechanism." @default.
- W4220778975 created "2022-04-03" @default.
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- W4220778975 date "2023-05-01" @default.
- W4220778975 modified "2023-10-14" @default.
- W4220778975 title "Remodeling of the ryanodine receptor isoform 1 channel regulates the sweet and umami taste perception of Rattus norvegicus" @default.
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- W4220778975 doi "https://doi.org/10.1016/j.fmre.2022.02.009" @default.
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