Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220779541> ?p ?o ?g. }
- W4220779541 endingPage "13" @default.
- W4220779541 startingPage "1" @default.
- W4220779541 abstract "Neuroinflammation is a critical pathological process of neurodegenerative diseases, and alleviating the inflammatory response caused by abnormally activated microglia might be valuable for treatment. The 18 kDa translocator protein (TSPO), a biomarker of neuroinflammation, is significantly elevated in activated microglia. However, the role of TSPO in microglia activation has not been well demonstrated. In this study, we evaluated the role of TSPO and its ligands PK11195 and Midazolam in LPS-activated BV-2 microglia cells involving mitophagy process and the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome activation. In the microglia-neuron coculture system, the neurotoxicity induced by LPS-activated microglia and the neuroprotective effects of PK11195 and Midazolam were evaluated. Our results showed that after being stimulated by LPS, the expression of TSPO was increased, and the process of mitophagy was inhibited in BV-2 microglia cells. Inhibition of mitophagy was reversed by pretreatment with PK11195 and Midazolam. And the NLRP3 inflammasome was increased in LPS-activated BV-2 microglia cells in the microglia-neuron coculture system; pretreatment with PK11195 and Midazolam limited this undesirable situation. Lastly, PK11195 and Midazolam improved the cell viability and reduced apoptosis of neuronal cells in the microglia-neuron coculture system. Taken together, TSPO ligands PK11195 and Midazolam showed neuroprotective effects by reducing the inflammatory response of LPS-activated microglia, which may be related to the enhancement of mitophagy and the inhibition of NLRP3 inflammasome." @default.
- W4220779541 created "2022-04-03" @default.
- W4220779541 creator A5005412189 @default.
- W4220779541 creator A5015744114 @default.
- W4220779541 creator A5018023415 @default.
- W4220779541 creator A5024545721 @default.
- W4220779541 creator A5027792053 @default.
- W4220779541 creator A5028711894 @default.
- W4220779541 creator A5041730288 @default.
- W4220779541 creator A5041811714 @default.
- W4220779541 creator A5057030725 @default.
- W4220779541 creator A5069187527 @default.
- W4220779541 creator A5081717248 @default.
- W4220779541 creator A5085352453 @default.
- W4220779541 date "2022-03-30" @default.
- W4220779541 modified "2023-10-10" @default.
- W4220779541 title "TSPO Ligands Protect against Neuronal Damage Mediated by LPS-Induced BV-2 Microglia Activation" @default.
- W4220779541 cites W1574200406 @default.
- W4220779541 cites W1964888681 @default.
- W4220779541 cites W1985538633 @default.
- W4220779541 cites W2031648971 @default.
- W4220779541 cites W2049016912 @default.
- W4220779541 cites W2076647919 @default.
- W4220779541 cites W2092013624 @default.
- W4220779541 cites W2098038342 @default.
- W4220779541 cites W2125461230 @default.
- W4220779541 cites W2163179762 @default.
- W4220779541 cites W2262781282 @default.
- W4220779541 cites W2275879522 @default.
- W4220779541 cites W2570634615 @default.
- W4220779541 cites W2592077895 @default.
- W4220779541 cites W2594094135 @default.
- W4220779541 cites W2735873011 @default.
- W4220779541 cites W2756642063 @default.
- W4220779541 cites W2786608785 @default.
- W4220779541 cites W2884031535 @default.
- W4220779541 cites W2884073029 @default.
- W4220779541 cites W2884445384 @default.
- W4220779541 cites W2889446669 @default.
- W4220779541 cites W2890625851 @default.
- W4220779541 cites W2890627020 @default.
- W4220779541 cites W2904217430 @default.
- W4220779541 cites W2911127509 @default.
- W4220779541 cites W2942886351 @default.
- W4220779541 cites W2947302792 @default.
- W4220779541 cites W2973473061 @default.
- W4220779541 cites W2983415011 @default.
- W4220779541 cites W2990312754 @default.
- W4220779541 cites W3030804042 @default.
- W4220779541 cites W3050737291 @default.
- W4220779541 cites W3056264410 @default.
- W4220779541 cites W3087325898 @default.
- W4220779541 cites W3094213593 @default.
- W4220779541 cites W3103775593 @default.
- W4220779541 cites W3112807738 @default.
- W4220779541 cites W3122385255 @default.
- W4220779541 cites W3189717352 @default.
- W4220779541 doi "https://doi.org/10.1155/2022/5896699" @default.
- W4220779541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35401924" @default.
- W4220779541 hasPublicationYear "2022" @default.
- W4220779541 type Work @default.
- W4220779541 citedByCount "5" @default.
- W4220779541 countsByYear W42207795412022 @default.
- W4220779541 countsByYear W42207795412023 @default.
- W4220779541 crossrefType "journal-article" @default.
- W4220779541 hasAuthorship W4220779541A5005412189 @default.
- W4220779541 hasAuthorship W4220779541A5015744114 @default.
- W4220779541 hasAuthorship W4220779541A5018023415 @default.
- W4220779541 hasAuthorship W4220779541A5024545721 @default.
- W4220779541 hasAuthorship W4220779541A5027792053 @default.
- W4220779541 hasAuthorship W4220779541A5028711894 @default.
- W4220779541 hasAuthorship W4220779541A5041730288 @default.
- W4220779541 hasAuthorship W4220779541A5041811714 @default.
- W4220779541 hasAuthorship W4220779541A5057030725 @default.
- W4220779541 hasAuthorship W4220779541A5069187527 @default.
- W4220779541 hasAuthorship W4220779541A5081717248 @default.
- W4220779541 hasAuthorship W4220779541A5085352453 @default.
- W4220779541 hasBestOaLocation W42207795411 @default.
- W4220779541 hasConcept C178790620 @default.
- W4220779541 hasConcept C185592680 @default.
- W4220779541 hasConcept C190283241 @default.
- W4220779541 hasConcept C203014093 @default.
- W4220779541 hasConcept C203522944 @default.
- W4220779541 hasConcept C25498285 @default.
- W4220779541 hasConcept C2776791281 @default.
- W4220779541 hasConcept C2776914184 @default.
- W4220779541 hasConcept C2777209026 @default.
- W4220779541 hasConcept C2779324830 @default.
- W4220779541 hasConcept C2779491297 @default.
- W4220779541 hasConcept C2779830541 @default.
- W4220779541 hasConcept C29730261 @default.
- W4220779541 hasConcept C55493867 @default.
- W4220779541 hasConcept C86803240 @default.
- W4220779541 hasConcept C87753298 @default.
- W4220779541 hasConcept C95444343 @default.
- W4220779541 hasConcept C98274493 @default.
- W4220779541 hasConceptScore W4220779541C178790620 @default.
- W4220779541 hasConceptScore W4220779541C185592680 @default.