Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220780134> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4220780134 abstract "Backgrounds: Polymyxin B， which is a last line antibiotic for multi-drug resistant gram-negative bacteria, has been reported to induce skin hyperpigmentation in patients during treatments. 8~15% or more cases were reported hyperpigmentation, especially in head and neck, seriously influencing the compliance of patients. To investigate the mechanism of hyperpigmentation is beneficial for intervention strategy and improve compliance. Methods: The melanoma cells, SK-MEL-2 cells were employed in the present study to verify whether polymyxin B treatment could directly induce hyperpigmentation. Melanin contents were measured by hot alkali lysis method and tyrosinase were quantified by dopaquinone oxidation method. The real-time quantitative PCR was applied to measure the mRNA levels of melanogenesis-related genes to investigate the possible signaling pathway involved in the polymyxin B induced hyperpigmentation. Results: The melanin content and tyrosinase activity were up-regulated after 5 μg/mL polymyxin B treatment in SK-MEL-2 cells at 48 hr. and 72 hr. The mRNA levels of melanogenesis-related genes were up-regulated, including PI3K, Akt, GSK-3β, CREB, MITF in the polymyxin B treatment group compared with control group at 48 hr. (p<0.001). Conclusions: In the present study, for the first time to reveal that polymyxin B induced hyperpigmentation involved the signaling pathway of PI3K/AKT/GSK-3β and the up-regulation of CREB and MITF subsequently, then induced the activity of tyrosinase and melanin content in melanoma cells." @default.
- W4220780134 created "2022-04-03" @default.
- W4220780134 creator A5009664126 @default.
- W4220780134 creator A5017947172 @default.
- W4220780134 creator A5022454308 @default.
- W4220780134 creator A5022526821 @default.
- W4220780134 creator A5062064445 @default.
- W4220780134 creator A5079594267 @default.
- W4220780134 creator A5085316750 @default.
- W4220780134 creator A5088568727 @default.
- W4220780134 creator A5069353181 @default.
- W4220780134 date "2022-03-30" @default.
- W4220780134 modified "2023-10-18" @default.
- W4220780134 title "PI3K/AKT/GSK-3β signaling pathway involving in the mechanism of polymyxin B induced melanogenesis" @default.
- W4220780134 doi "https://doi.org/10.22541/au.164864255.52225423/v1" @default.
- W4220780134 hasPublicationYear "2022" @default.
- W4220780134 type Work @default.
- W4220780134 citedByCount "0" @default.
- W4220780134 crossrefType "posted-content" @default.
- W4220780134 hasAuthorship W4220780134A5009664126 @default.
- W4220780134 hasAuthorship W4220780134A5017947172 @default.
- W4220780134 hasAuthorship W4220780134A5022454308 @default.
- W4220780134 hasAuthorship W4220780134A5022526821 @default.
- W4220780134 hasAuthorship W4220780134A5062064445 @default.
- W4220780134 hasAuthorship W4220780134A5069353181 @default.
- W4220780134 hasAuthorship W4220780134A5079594267 @default.
- W4220780134 hasAuthorship W4220780134A5085316750 @default.
- W4220780134 hasAuthorship W4220780134A5088568727 @default.
- W4220780134 hasBestOaLocation W42207801341 @default.
- W4220780134 hasConcept C104317684 @default.
- W4220780134 hasConcept C107538193 @default.
- W4220780134 hasConcept C1629964 @default.
- W4220780134 hasConcept C177504595 @default.
- W4220780134 hasConcept C181199279 @default.
- W4220780134 hasConcept C185592680 @default.
- W4220780134 hasConcept C2776728111 @default.
- W4220780134 hasConcept C2780026444 @default.
- W4220780134 hasConcept C2780675486 @default.
- W4220780134 hasConcept C2909381827 @default.
- W4220780134 hasConcept C501593827 @default.
- W4220780134 hasConcept C55493867 @default.
- W4220780134 hasConcept C62478195 @default.
- W4220780134 hasConcept C71924100 @default.
- W4220780134 hasConcept C75217442 @default.
- W4220780134 hasConcept C86339819 @default.
- W4220780134 hasConcept C86554907 @default.
- W4220780134 hasConcept C87554066 @default.
- W4220780134 hasConcept C98274493 @default.
- W4220780134 hasConceptScore W4220780134C104317684 @default.
- W4220780134 hasConceptScore W4220780134C107538193 @default.
- W4220780134 hasConceptScore W4220780134C1629964 @default.
- W4220780134 hasConceptScore W4220780134C177504595 @default.
- W4220780134 hasConceptScore W4220780134C181199279 @default.
- W4220780134 hasConceptScore W4220780134C185592680 @default.
- W4220780134 hasConceptScore W4220780134C2776728111 @default.
- W4220780134 hasConceptScore W4220780134C2780026444 @default.
- W4220780134 hasConceptScore W4220780134C2780675486 @default.
- W4220780134 hasConceptScore W4220780134C2909381827 @default.
- W4220780134 hasConceptScore W4220780134C501593827 @default.
- W4220780134 hasConceptScore W4220780134C55493867 @default.
- W4220780134 hasConceptScore W4220780134C62478195 @default.
- W4220780134 hasConceptScore W4220780134C71924100 @default.
- W4220780134 hasConceptScore W4220780134C75217442 @default.
- W4220780134 hasConceptScore W4220780134C86339819 @default.
- W4220780134 hasConceptScore W4220780134C86554907 @default.
- W4220780134 hasConceptScore W4220780134C87554066 @default.
- W4220780134 hasConceptScore W4220780134C98274493 @default.
- W4220780134 hasLocation W42207801341 @default.
- W4220780134 hasOpenAccess W4220780134 @default.
- W4220780134 hasPrimaryLocation W42207801341 @default.
- W4220780134 hasRelatedWork W2045787205 @default.
- W4220780134 hasRelatedWork W2400849592 @default.
- W4220780134 hasRelatedWork W2750522373 @default.
- W4220780134 hasRelatedWork W2777836631 @default.
- W4220780134 hasRelatedWork W2805975731 @default.
- W4220780134 hasRelatedWork W2914273419 @default.
- W4220780134 hasRelatedWork W3200139384 @default.
- W4220780134 hasRelatedWork W3212997363 @default.
- W4220780134 hasRelatedWork W4220780134 @default.
- W4220780134 hasRelatedWork W4312210067 @default.
- W4220780134 isParatext "false" @default.
- W4220780134 isRetracted "false" @default.
- W4220780134 workType "article" @default.