FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220781008> ?p ?o ?g. }

• W4220781008 abstract "The role of natural killer (NK) cells in juvenile-onset recurrent respiratory papillomatosis (JORRP) patients remains elusive. In this study, we find increased NK cell percentage, particularly CD11b-CD27- (DN) subsets in peripheral blood of JORRP patients and associated with disease activity. RNA sequencing shows a downregulated “natural killer cell-mediated cytotoxicity” feature in JORRP tumors. We also find impaired cytotoxic capacity and lower expression of NK cell-activating receptors including NKp30 and NKp46. Higher transforming growth factor-beta 1 (TGF-β1) is found both in plasma and tumor tissues of JORRP, and anti-TGF-β1 antibody could restore NK cell cytolytic activity and upregulate NKp30 and NKG2D expression. Also, we find a significantly higher Chemokine receptor type 6 (CXCR6) on NK cells in tumors compared with that in peripheral blood. Finally, RT-PCR analysis show that both HPV6-E6-E7 and HPV11-E6-E7 overexpression leads to higher TGFB1 expression compared with control SNU-1076 cell line, and higher CXCR6 expression is detected on NK coculture with HPV11-E6-E7-overexpressing cells. In conclusion, we demonstrate that TGF-β1 by papillomatosis leads to decreased NK cell cytotoxicity through downregulating NK cell-activating receptors in JORRP patients." @default.
• W4220781008 created "2022-04-03" @default.
• W4220781008 creator A5005149807 @default.
• W4220781008 creator A5013395304 @default.
• W4220781008 creator A5014725864 @default.
• W4220781008 creator A5036200124 @default.
• W4220781008 creator A5048843486 @default.
• W4220781008 date "2022-03-08" @default.
• W4220781008 modified "2023-10-16" @default.
• W4220781008 title "Reduced NK Cell Cytotoxicity by Papillomatosis-Derived TGF-β Contributing to Low-Risk HPV Persistence in JORRP Patients" @default.
• W4220781008 cites W1560092366 @default.
• W4220781008 cites W1976563894 @default.
• W4220781008 cites W1984455211 @default.
• W4220781008 cites W2045598455 @default.
• W4220781008 cites W2047846334 @default.
• W4220781008 cites W2051465794 @default.
• W4220781008 cites W2065341824 @default.
• W4220781008 cites W2075873658 @default.
• W4220781008 cites W2085309730 @default.
• W4220781008 cites W2137601145 @default.
• W4220781008 cites W2137970297 @default.
• W4220781008 cites W2151058118 @default.
• W4220781008 cites W2196639367 @default.
• W4220781008 cites W2466776366 @default.
• W4220781008 cites W2521123529 @default.
• W4220781008 cites W2555055728 @default.
• W4220781008 cites W2565448904 @default.
• W4220781008 cites W2740001104 @default.
• W4220781008 cites W2741163567 @default.
• W4220781008 cites W2747249535 @default.
• W4220781008 cites W2750092411 @default.
• W4220781008 cites W2791855274 @default.
• W4220781008 cites W2899573186 @default.
• W4220781008 cites W2913289941 @default.
• W4220781008 cites W2915822971 @default.
• W4220781008 cites W2918519373 @default.
• W4220781008 cites W2942336783 @default.
• W4220781008 cites W2944669628 @default.
• W4220781008 cites W2953740029 @default.
• W4220781008 cites W2971459028 @default.
• W4220781008 cites W2983497119 @default.
• W4220781008 cites W2986121805 @default.
• W4220781008 cites W3001496296 @default.
• W4220781008 cites W3006483160 @default.
• W4220781008 cites W3011436447 @default.
• W4220781008 cites W3194594621 @default.
• W4220781008 cites W3205785087 @default.
• W4220781008 cites W35267829 @default.
• W4220781008 cites W4285719527 @default.
• W4220781008 cites W4288058932 @default.
• W4220781008 doi "https://doi.org/10.3389/fimmu.2022.849493" @default.
• W4220781008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35350785" @default.
• W4220781008 hasPublicationYear "2022" @default.
• W4220781008 type Work @default.
• W4220781008 citedByCount "4" @default.
• W4220781008 countsByYear W42207810082022 @default.
• W4220781008 countsByYear W42207810082023 @default.
• W4220781008 crossrefType "journal-article" @default.
• W4220781008 hasAuthorship W4220781008A5005149807 @default.
• W4220781008 hasAuthorship W4220781008A5013395304 @default.
• W4220781008 hasAuthorship W4220781008A5014725864 @default.
• W4220781008 hasAuthorship W4220781008A5036200124 @default.
• W4220781008 hasAuthorship W4220781008A5048843486 @default.
• W4220781008 hasBestOaLocation W42207810081 @default.
• W4220781008 hasConcept C105702510 @default.
• W4220781008 hasConcept C109316439 @default.
• W4220781008 hasConcept C12823836 @default.
• W4220781008 hasConcept C13373296 @default.
• W4220781008 hasConcept C154317977 @default.
• W4220781008 hasConcept C159654299 @default.
• W4220781008 hasConcept C202751555 @default.
• W4220781008 hasConcept C203014093 @default.
• W4220781008 hasConcept C2775866117 @default.
• W4220781008 hasConcept C2778102761 @default.
• W4220781008 hasConcept C2778867473 @default.
• W4220781008 hasConcept C2780474809 @default.
• W4220781008 hasConcept C2910019179 @default.
• W4220781008 hasConcept C40677261 @default.
• W4220781008 hasConcept C502942594 @default.
• W4220781008 hasConcept C542903549 @default.
• W4220781008 hasConcept C55493867 @default.
• W4220781008 hasConcept C86803240 @default.
• W4220781008 hasConcept C8891405 @default.
• W4220781008 hasConceptScore W4220781008C105702510 @default.
• W4220781008 hasConceptScore W4220781008C109316439 @default.
• W4220781008 hasConceptScore W4220781008C12823836 @default.
• W4220781008 hasConceptScore W4220781008C13373296 @default.
• W4220781008 hasConceptScore W4220781008C154317977 @default.
• W4220781008 hasConceptScore W4220781008C159654299 @default.
• W4220781008 hasConceptScore W4220781008C202751555 @default.
• W4220781008 hasConceptScore W4220781008C203014093 @default.
• W4220781008 hasConceptScore W4220781008C2775866117 @default.
• W4220781008 hasConceptScore W4220781008C2778102761 @default.
• W4220781008 hasConceptScore W4220781008C2778867473 @default.
• W4220781008 hasConceptScore W4220781008C2780474809 @default.
• W4220781008 hasConceptScore W4220781008C2910019179 @default.
• W4220781008 hasConceptScore W4220781008C40677261 @default.
• W4220781008 hasConceptScore W4220781008C502942594 @default.
• W4220781008 hasConceptScore W4220781008C542903549 @default.
• W4220781008 hasConceptScore W4220781008C55493867 @default.

• next