Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220782046> ?p ?o ?g. }
- W4220782046 endingPage "945" @default.
- W4220782046 startingPage "936" @default.
- W4220782046 abstract "COVID-19 vaccines prevent severe forms of the disease, but do not warrant complete protection against breakthrough infections. This could be due to suboptimal mucosal immunity at the site of virus entry, given that all currently approved vaccines are administered via the intramuscular route. In this study, we assessed humoral and cellular immune responses in BALB/c mice after intranasal and intramuscular immunization with adenoviral vector ChAdOx1-S expressing full-length Spike protein of SARS-CoV-2. We showed that both routes of vaccination induced a potent IgG antibody response, as well as robust neutralizing capacity, but intranasal vaccination elicited a superior IgA antibody titer in the sera and in the respiratory mucosa. Bronchoalveolar lavage from intranasally immunized mice efficiently neutralized SARS-CoV-2, which has not been the case in intramuscularly immunized group. Moreover, substantially higher percentages of epitope-specific CD8 T cells exhibiting a tissue resident phenotype were found in the lungs of intranasally immunized animals. Finally, both intranasal and intramuscular vaccination with ChAdOx1-S efficiently protected the mice after the challenge with recombinant herpesvirus expressing the Spike protein. Our results demonstrate that intranasal application of adenoviral vector ChAdOx1-S induces superior mucosal immunity and therefore could be a promising strategy for putting the COVID-19 pandemic under control." @default.
- W4220782046 created "2022-04-03" @default.
- W4220782046 creator A5000623894 @default.
- W4220782046 creator A5002355345 @default.
- W4220782046 creator A5017232542 @default.
- W4220782046 creator A5018061229 @default.
- W4220782046 creator A5020330068 @default.
- W4220782046 creator A5020630796 @default.
- W4220782046 creator A5025090132 @default.
- W4220782046 creator A5026424307 @default.
- W4220782046 creator A5032941389 @default.
- W4220782046 creator A5038051461 @default.
- W4220782046 creator A5042057389 @default.
- W4220782046 creator A5044182395 @default.
- W4220782046 creator A5044457664 @default.
- W4220782046 creator A5052845799 @default.
- W4220782046 creator A5058279269 @default.
- W4220782046 creator A5067875517 @default.
- W4220782046 creator A5070847454 @default.
- W4220782046 creator A5081869877 @default.
- W4220782046 creator A5088042204 @default.
- W4220782046 creator A5088466792 @default.
- W4220782046 date "2022-03-31" @default.
- W4220782046 modified "2023-10-16" @default.
- W4220782046 title "ChAdOx1‐S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination" @default.
- W4220782046 cites W2012102254 @default.
- W4220782046 cites W2099149491 @default.
- W4220782046 cites W2105415231 @default.
- W4220782046 cites W2115813759 @default.
- W4220782046 cites W2365822624 @default.
- W4220782046 cites W2673562052 @default.
- W4220782046 cites W2884137508 @default.
- W4220782046 cites W2885513998 @default.
- W4220782046 cites W2973957080 @default.
- W4220782046 cites W2982641611 @default.
- W4220782046 cites W3042833857 @default.
- W4220782046 cites W3049654234 @default.
- W4220782046 cites W3086125063 @default.
- W4220782046 cites W3111255098 @default.
- W4220782046 cites W3111590711 @default.
- W4220782046 cites W3121177038 @default.
- W4220782046 cites W3138437538 @default.
- W4220782046 cites W3153508314 @default.
- W4220782046 cites W3153636933 @default.
- W4220782046 cites W3166555921 @default.
- W4220782046 cites W3171609527 @default.
- W4220782046 cites W3174633785 @default.
- W4220782046 cites W3179359240 @default.
- W4220782046 cites W3184287782 @default.
- W4220782046 cites W3188350838 @default.
- W4220782046 cites W3205166428 @default.
- W4220782046 cites W3216348181 @default.
- W4220782046 cites W3216944372 @default.
- W4220782046 cites W4200079077 @default.
- W4220782046 cites W4200368137 @default.
- W4220782046 cites W4200539520 @default.
- W4220782046 cites W4205483821 @default.
- W4220782046 cites W4212869616 @default.
- W4220782046 cites W4225411516 @default.
- W4220782046 cites W4226120088 @default.
- W4220782046 doi "https://doi.org/10.1002/eji.202249823" @default.
- W4220782046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35304741" @default.
- W4220782046 hasPublicationYear "2022" @default.
- W4220782046 type Work @default.
- W4220782046 citedByCount "7" @default.
- W4220782046 countsByYear W42207820462022 @default.
- W4220782046 countsByYear W42207820462023 @default.
- W4220782046 crossrefType "journal-article" @default.
- W4220782046 hasAuthorship W4220782046A5000623894 @default.
- W4220782046 hasAuthorship W4220782046A5002355345 @default.
- W4220782046 hasAuthorship W4220782046A5017232542 @default.
- W4220782046 hasAuthorship W4220782046A5018061229 @default.
- W4220782046 hasAuthorship W4220782046A5020330068 @default.
- W4220782046 hasAuthorship W4220782046A5020630796 @default.
- W4220782046 hasAuthorship W4220782046A5025090132 @default.
- W4220782046 hasAuthorship W4220782046A5026424307 @default.
- W4220782046 hasAuthorship W4220782046A5032941389 @default.
- W4220782046 hasAuthorship W4220782046A5038051461 @default.
- W4220782046 hasAuthorship W4220782046A5042057389 @default.
- W4220782046 hasAuthorship W4220782046A5044182395 @default.
- W4220782046 hasAuthorship W4220782046A5044457664 @default.
- W4220782046 hasAuthorship W4220782046A5052845799 @default.
- W4220782046 hasAuthorship W4220782046A5058279269 @default.
- W4220782046 hasAuthorship W4220782046A5067875517 @default.
- W4220782046 hasAuthorship W4220782046A5070847454 @default.
- W4220782046 hasAuthorship W4220782046A5081869877 @default.
- W4220782046 hasAuthorship W4220782046A5088042204 @default.
- W4220782046 hasAuthorship W4220782046A5088466792 @default.
- W4220782046 hasBestOaLocation W42207820462 @default.
- W4220782046 hasConcept C104317684 @default.
- W4220782046 hasConcept C159047783 @default.
- W4220782046 hasConcept C159654299 @default.
- W4220782046 hasConcept C203014093 @default.
- W4220782046 hasConcept C22070199 @default.
- W4220782046 hasConcept C2776548049 @default.
- W4220782046 hasConcept C2779261636 @default.
- W4220782046 hasConcept C2779341262 @default.
- W4220782046 hasConcept C2780801004 @default.