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- W4220783424 endingPage "2905" @default.
- W4220783424 startingPage "2905" @default.
- W4220783424 abstract "For over a century, the role of the preoptic hypothalamus and adjacent basal forebrain in sleep-wake regulation has been recognized. However, for years, the identity and location of sleep- and wake-promoting neurons in this region remained largely unresolved. Twenty-five years ago, Saper and colleagues uncovered a small collection of sleep-active neurons in the ventrolateral preoptic nucleus (VLPO) of the preoptic hypothalamus, and since this seminal discovery the VLPO has been intensively investigated by labs around the world, including our own. Herein, we first review the history of the preoptic area, with an emphasis on the VLPO in sleep-wake control. We then attempt to synthesize our current understanding of the circuit, cellular and synaptic bases by which the VLPO both regulates and is itself regulated, in order to exert a powerful control over behavioral state, as well as examining data suggesting an involvement of the VLPO in other physiological processes." @default.
- W4220783424 created "2022-04-03" @default.
- W4220783424 creator A5026809730 @default.
- W4220783424 creator A5055163801 @default.
- W4220783424 date "2022-03-08" @default.
- W4220783424 modified "2023-10-15" @default.
- W4220783424 title "The Sleep-Promoting Ventrolateral Preoptic Nucleus: What Have We Learned over the Past 25 Years?" @default.
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