Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220783494> ?p ?o ?g. }
- W4220783494 abstract "ABSTRACT Resident and recruited macrophages control the development and proliferation of the liver. We have previously shown in multiple species that treatment with a macrophage colony stimulating factor (CSF1)-Fc fusion protein initiated hepatocyte proliferation and promoted repair in models of acute hepatic injury in mice. Here, we investigated the impact of CSF1-Fc on resolution of advanced fibrosis and liver regeneration, using a non-resolving toxin-induced model of chronic liver injury and fibrosis in C57BL/6J mice. Co-administration of CSF1-Fc with exposure to thioacetamide (TAA) exacerbated inflammation consistent with monocyte contributions to initiation of pathology. After removal of TAA, either acute or chronic CSF1-Fc treatment promoted liver growth, prevented progression and promoted resolution of fibrosis. Acute CSF1-Fc treatment was also anti-fibrotic and pro-regenerative in a model of partial hepatectomy in mice with established fibrosis. The beneficial impacts of CSF1-Fc treatment were associated with monocyte-macrophage recruitment and increased expression of remodelling enzymes and growth factors. These studies indicate that CSF1-dependent macrophages contribute to both initiation and resolution of fibrotic injury and that CSF1-Fc has therapeutic potential in human liver disease." @default.
- W4220783494 created "2022-04-03" @default.
- W4220783494 creator A5003769756 @default.
- W4220783494 creator A5016516554 @default.
- W4220783494 creator A5017977416 @default.
- W4220783494 creator A5023418406 @default.
- W4220783494 creator A5034604471 @default.
- W4220783494 creator A5038250336 @default.
- W4220783494 creator A5045601521 @default.
- W4220783494 creator A5048627047 @default.
- W4220783494 creator A5057306266 @default.
- W4220783494 creator A5063583921 @default.
- W4220783494 creator A5068722957 @default.
- W4220783494 creator A5074496476 @default.
- W4220783494 creator A5077509611 @default.
- W4220783494 creator A5081026788 @default.
- W4220783494 creator A5083402180 @default.
- W4220783494 creator A5086464749 @default.
- W4220783494 creator A5086500057 @default.
- W4220783494 creator A5091187950 @default.
- W4220783494 date "2022-04-01" @default.
- W4220783494 modified "2023-09-29" @default.
- W4220783494 title "Therapeutic potential of macrophage colony-stimulating factor in chronic liver disease" @default.
- W4220783494 cites W1529809181 @default.
- W4220783494 cites W1807054663 @default.
- W4220783494 cites W1879194923 @default.
- W4220783494 cites W18982853 @default.
- W4220783494 cites W1953291717 @default.
- W4220783494 cites W1968925643 @default.
- W4220783494 cites W1972126834 @default.
- W4220783494 cites W1980325398 @default.
- W4220783494 cites W1983188536 @default.
- W4220783494 cites W1987844765 @default.
- W4220783494 cites W2004709015 @default.
- W4220783494 cites W2008621673 @default.
- W4220783494 cites W2008924384 @default.
- W4220783494 cites W2018046176 @default.
- W4220783494 cites W2023149416 @default.
- W4220783494 cites W2042386759 @default.
- W4220783494 cites W2046768800 @default.
- W4220783494 cites W2072801301 @default.
- W4220783494 cites W2073415492 @default.
- W4220783494 cites W2090738619 @default.
- W4220783494 cites W2103863906 @default.
- W4220783494 cites W2104116192 @default.
- W4220783494 cites W2104676478 @default.
- W4220783494 cites W2118363577 @default.
- W4220783494 cites W2126915565 @default.
- W4220783494 cites W2127580144 @default.
- W4220783494 cites W2133860937 @default.
- W4220783494 cites W2141006081 @default.
- W4220783494 cites W2163386417 @default.
- W4220783494 cites W2167794093 @default.
- W4220783494 cites W2167818251 @default.
- W4220783494 cites W2220594341 @default.
- W4220783494 cites W2231409040 @default.
- W4220783494 cites W2324163874 @default.
- W4220783494 cites W2335708867 @default.
- W4220783494 cites W2341070770 @default.
- W4220783494 cites W2467815567 @default.
- W4220783494 cites W2493456104 @default.
- W4220783494 cites W2560971730 @default.
- W4220783494 cites W2566211026 @default.
- W4220783494 cites W2594352786 @default.
- W4220783494 cites W2594491387 @default.
- W4220783494 cites W2601083211 @default.
- W4220783494 cites W2770634512 @default.
- W4220783494 cites W2784608122 @default.
- W4220783494 cites W2789547963 @default.
- W4220783494 cites W2885800282 @default.
- W4220783494 cites W2893835498 @default.
- W4220783494 cites W2901423145 @default.
- W4220783494 cites W2905503365 @default.
- W4220783494 cites W2913970656 @default.
- W4220783494 cites W2915844574 @default.
- W4220783494 cites W2917277724 @default.
- W4220783494 cites W2921132259 @default.
- W4220783494 cites W2944258220 @default.
- W4220783494 cites W2950214167 @default.
- W4220783494 cites W2968071898 @default.
- W4220783494 cites W2968470226 @default.
- W4220783494 cites W2978004942 @default.
- W4220783494 cites W2979268390 @default.
- W4220783494 cites W3001215024 @default.
- W4220783494 cites W3001420005 @default.
- W4220783494 cites W3017134069 @default.
- W4220783494 cites W3041246764 @default.
- W4220783494 cites W3047433286 @default.
- W4220783494 cites W3048499400 @default.
- W4220783494 cites W3088449656 @default.
- W4220783494 cites W3092551009 @default.
- W4220783494 cites W3095484986 @default.
- W4220783494 cites W3096243080 @default.
- W4220783494 cites W3096816466 @default.
- W4220783494 cites W3152047148 @default.
- W4220783494 cites W3170023211 @default.
- W4220783494 cites W4200254979 @default.
- W4220783494 cites W4250007760 @default.
- W4220783494 doi "https://doi.org/10.1242/dmm.049387" @default.
- W4220783494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35169835" @default.