Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220783622> ?p ?o ?g. }
- W4220783622 endingPage "199" @default.
- W4220783622 startingPage "190" @default.
- W4220783622 abstract "Nanomedicine offered hope for improving the treatment of cancer but the survival benefits of the clinically approved nanomedicines are modest in many cases when compared to conventional chemotherapy. Metronomic therapy, defined as the frequent, low dose administration of chemotherapeutics - is being tested in clinical trials as an alternative to the conventional maximum tolerated dose (MTD) chemotherapy schedule. Although metronomic chemotherapy has not been clinically approved yet, it has shown better survival than MTD in many preclinical studies. When beneficial, metronomic therapy seems to be associated with normalization of the tumor microenvironment including improvements in tumor perfusion, tissue oxygenation and drug delivery as well as activation of the immune system. Recent preclinical studies suggest that nanomedicines can cause similar changes in the tumor microenvironment. Here, by employing a mathematical framework, we show that both approaches can serve as normalization strategies to enhance treatment. Furthermore, employing murine breast and fibrosarcoma tumor models as well as ultrasound shear wave elastography and contrast-enhanced ultrasound, we provide evidence that the approved nanomedicine Doxil can induce normalization in a dose-dependent manner by improving tumor perfusion as a result of tissue softening. Finally, we show that pretreatment with a normalizing dose of Doxil can improve the efficacy of immune checkpoint inhibition." @default.
- W4220783622 created "2022-04-03" @default.
- W4220783622 creator A5003082907 @default.
- W4220783622 creator A5015585176 @default.
- W4220783622 creator A5040343131 @default.
- W4220783622 creator A5057504407 @default.
- W4220783622 creator A5079241025 @default.
- W4220783622 creator A5084140964 @default.
- W4220783622 date "2022-05-01" @default.
- W4220783622 modified "2023-10-13" @default.
- W4220783622 title "Normalizing tumor microenvironment with nanomedicine and metronomic therapy to improve immunotherapy" @default.
- W4220783622 cites W1063491141 @default.
- W4220783622 cites W1556819620 @default.
- W4220783622 cites W1557142436 @default.
- W4220783622 cites W1568339005 @default.
- W4220783622 cites W1603230122 @default.
- W4220783622 cites W1963655681 @default.
- W4220783622 cites W1968583232 @default.
- W4220783622 cites W1971026321 @default.
- W4220783622 cites W1972135632 @default.
- W4220783622 cites W1972146805 @default.
- W4220783622 cites W1983530966 @default.
- W4220783622 cites W1985858988 @default.
- W4220783622 cites W1998266575 @default.
- W4220783622 cites W2006202974 @default.
- W4220783622 cites W2014282546 @default.
- W4220783622 cites W2022540958 @default.
- W4220783622 cites W2030646983 @default.
- W4220783622 cites W2032986552 @default.
- W4220783622 cites W2047959632 @default.
- W4220783622 cites W2074544404 @default.
- W4220783622 cites W2081820338 @default.
- W4220783622 cites W2082412368 @default.
- W4220783622 cites W2090806526 @default.
- W4220783622 cites W2094785364 @default.
- W4220783622 cites W2102866212 @default.
- W4220783622 cites W2118365548 @default.
- W4220783622 cites W2126163864 @default.
- W4220783622 cites W2137816700 @default.
- W4220783622 cites W2143203694 @default.
- W4220783622 cites W2158303916 @default.
- W4220783622 cites W2167798860 @default.
- W4220783622 cites W2169965478 @default.
- W4220783622 cites W2170193835 @default.
- W4220783622 cites W218692517 @default.
- W4220783622 cites W2303436115 @default.
- W4220783622 cites W2309770165 @default.
- W4220783622 cites W2344644350 @default.
- W4220783622 cites W2345662229 @default.
- W4220783622 cites W2471959940 @default.
- W4220783622 cites W2510143430 @default.
- W4220783622 cites W2531093247 @default.
- W4220783622 cites W2543004764 @default.
- W4220783622 cites W2549514299 @default.
- W4220783622 cites W2567825448 @default.
- W4220783622 cites W2586781596 @default.
- W4220783622 cites W2586843734 @default.
- W4220783622 cites W2587926752 @default.
- W4220783622 cites W2606343471 @default.
- W4220783622 cites W2727515347 @default.
- W4220783622 cites W2727766182 @default.
- W4220783622 cites W2743577629 @default.
- W4220783622 cites W2769133871 @default.
- W4220783622 cites W2793869682 @default.
- W4220783622 cites W2802690679 @default.
- W4220783622 cites W2897422388 @default.
- W4220783622 cites W2897523860 @default.
- W4220783622 cites W2909301717 @default.
- W4220783622 cites W2909932177 @default.
- W4220783622 cites W2924910315 @default.
- W4220783622 cites W2935731174 @default.
- W4220783622 cites W2972159813 @default.
- W4220783622 cites W2975889253 @default.
- W4220783622 cites W3003714437 @default.
- W4220783622 cites W3003951026 @default.
- W4220783622 cites W3004769637 @default.
- W4220783622 cites W3010803877 @default.
- W4220783622 cites W3012904002 @default.
- W4220783622 cites W3039872033 @default.
- W4220783622 cites W3042686911 @default.
- W4220783622 cites W3089860158 @default.
- W4220783622 cites W3091906446 @default.
- W4220783622 cites W3112322911 @default.
- W4220783622 cites W3130926674 @default.
- W4220783622 cites W3165564116 @default.
- W4220783622 cites W3171627245 @default.
- W4220783622 cites W3199169464 @default.
- W4220783622 cites W609539997 @default.
- W4220783622 doi "https://doi.org/10.1016/j.jconrel.2022.03.008" @default.
- W4220783622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35271911" @default.
- W4220783622 hasPublicationYear "2022" @default.
- W4220783622 type Work @default.
- W4220783622 citedByCount "19" @default.
- W4220783622 countsByYear W42207836222022 @default.
- W4220783622 countsByYear W42207836222023 @default.
- W4220783622 crossrefType "journal-article" @default.
- W4220783622 hasAuthorship W4220783622A5003082907 @default.
- W4220783622 hasAuthorship W4220783622A5015585176 @default.