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- W4220784482 abstract "The coronavirus disease 2019 (COVID-19), caused by a novel coronavirus (SARS-CoV-2), has spread worldwide, affecting over 250 million people and resulting in over five million deaths. Antivirals that are effective are still limited. The antiviral activities of the Petasites hybdridus CO2 extract Ze 339 were previously reported. Thus, to assess the anti-SARS-CoV-2 activity of Ze 339 as well as isopetasin and neopetasin as major active compounds, a CPE and plaque reduction assay in Vero E6 cells was used for viral output. Antiviral effects were tested using the original virus (Wuhan) and the Delta variant of SARS-CoV-2. The antiviral drug remdesivir was used as control. Pre-treatment with Ze 339 in SARS-CoV-2-infected Vero E6 cells with either virus variant significantly inhibited virus replication with IC50 values of 0.10 and 0.40 μg/mL, respectively. The IC50 values obtained for isopetasin ranged between 0.37 and 0.88 μM for both virus variants, and that of remdesivir ranged between 1.53 and 2.37 μM. In conclusion, Ze 339 as well as the petasins potently inhibited SARS-CoV-2 replication in vitro of the Wuhan and Delta variants. Since time is of essence in finding effective treatments, clinical studies will have to demonstrate if Ze339 can become a therapeutic option to treat SARS-CoV-2 infections." @default.
- W4220784482 created "2022-04-03" @default.
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- W4220784482 date "2022-01-07" @default.
- W4220784482 modified "2023-10-14" @default.
- W4220784482 title "The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro" @default.
- W4220784482 cites W1936798053 @default.
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- W4220784482 cites W1971668243 @default.
- W4220784482 cites W1978425319 @default.
- W4220784482 cites W1982437898 @default.
- W4220784482 cites W2007187686 @default.
- W4220784482 cites W2025563699 @default.
- W4220784482 cites W2028142158 @default.
- W4220784482 cites W2028304696 @default.
- W4220784482 cites W2037544021 @default.
- W4220784482 cites W2052907531 @default.
- W4220784482 cites W2055584532 @default.
- W4220784482 cites W2061777515 @default.
- W4220784482 cites W2093287488 @default.
- W4220784482 cites W2105649494 @default.
- W4220784482 cites W2129872180 @default.
- W4220784482 cites W2135732933 @default.
- W4220784482 cites W2157491227 @default.
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- W4220784482 cites W3020710323 @default.
- W4220784482 cites W3023169013 @default.
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- W4220784482 cites W3043870823 @default.
- W4220784482 cites W3048558600 @default.
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- W4220784482 cites W3090886099 @default.
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- W4220784482 cites W3125622076 @default.
- W4220784482 cites W3130263757 @default.
- W4220784482 cites W3130872060 @default.
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- W4220784482 cites W3207750149 @default.
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- W4220784482 doi "https://doi.org/10.3390/v14010106" @default.
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