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- W4220784534 endingPage "112814" @default.
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- W4220784534 abstract "The human fungal pathogen Candida albicans can cause many kinds of infections, including biofilm infections on medical devices, while the available antifungal drugs are limited to only a few. In this study, alantolactone (Ala) demonstrated antifungal activities against C. albicans, as well as other Candida species, with a MIC of 72 μg/mL. Ala could also inhibit the adhesion, yeast-to-hyphal transition, biofilm formation and development of C. albicans. The exopolysaccharide of biofilm matrix and extracellular phospholipase production could also be reduced by Ala treatment. Ala could increase permeability of C. albicans cell membrane and ROS contribute to the anti-biofilm activity of Ala. Overall, the present study suggests that Ala may provide a promising candidate for developing antifungal drugs against C. albicans infections." @default.
- W4220784534 created "2022-04-03" @default.
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- W4220784534 date "2022-05-01" @default.
- W4220784534 modified "2023-10-14" @default.
- W4220784534 title "Antifungal effects of alantolactone on Candida albicans: An in vitro study" @default.
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- W4220784534 doi "https://doi.org/10.1016/j.biopha.2022.112814" @default.
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