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• W4220786656 endingPage "339737" @default.
• W4220786656 startingPage "339737" @default.
• W4220786656 abstract "The kidney is a vital organ and susceptible to various diseases. Photoacoustic (PA) imaging provides a powerful technique for studying kidney dysfunction, for which many smart photoacoustic imaging agents have been developed. But the complete clearance of the introduced contrast agents after imaging remains to be challenging, leading to long-term toxicity concerns. In this study, we synthesized black phosphorous quantum dots (BPQDs) with ultra-small size (1.74 ± 0.23 nm after surface modification) and strong PA signal for imaging kidney dysfunction. Importantly, the renal-clearance property and biodegradability of the developed BPQDs help circumvent the long-term toxicity issue for in vivo studies. Based on these BPQDs, both acute kidney injury and chronic kidney disease were successfully detected in the living mice by PA imaging, with higher detection sensitivity than the clinical serum indices examination method. This BPQDs-based PA imaging method should have a promising potential for the early diagnosis of kidney dysfunction in clinic." @default.
• W4220786656 created "2022-04-03" @default.
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• W4220786656 date "2022-04-01" @default.
• W4220786656 modified "2023-09-23" @default.
• W4220786656 title "Renal-clearable and biodegradable black phosphorus quantum dots for photoacoustic imaging of kidney dysfunction" @default.
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• W4220786656 doi "https://doi.org/10.1016/j.aca.2022.339737" @default.
• W4220786656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35397900" @default.
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