Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220786677> ?p ?o ?g. }
- W4220786677 abstract "Cerebrospinal kappa free light chain (KFLC)-index is a marker of intrathecal immunoglobulin synthesis that aids in the diagnosis of multiple sclerosis (MS). However, little evidence exists on its prognostic role. Our aim is to analyze the relationship between KFLC-index and other MS biomarkers and to explore its prognostic role. This is a monocentric observational study in a cohort of 52 people with relapsing MS (pwRMS) performed on prospectively acquired clinical data and with retrospective evaluation of biomarkers. We measured KFLC-index, immunoglobulin intrathecal synthesis, cerebrospinal fluid (CSF) chitinase 3-like 1 (CHI3L1), and neurofilament light protein (NFL) and reviewed MRI to detect leptomeningeal contrast enhancement (LMCE). We compared time to Expanded Disability Status Scale (EDSS) 3 and to initiation of high-efficacy disease-modifying therapies (heDMTs) by multivariate Cox regression analysis. Median KFLC-index correlated with IgG/IgM indexes (p < 0.0001/p < 0.05) and IgG-oligoclonal bands (OCGBs) (p < 0.001). Patients with IgM-oligoclonal bands (OCMBs) had a higher KFLC-index (p = 0.049). KFLC-index was higher in patients with LMCE (p = 0.008) and correlated with CHI3L1 (p = 0.007), but disease activity had no effect on its value. Bivariate and multivariate analyses confirmed KFLC-index > 58 as an independent risk factor for reaching an EDSS of 3 (hazard ratio (HR) = 12.4; 95% CI = 1.1-147; p = 0.047) and for the need of treatment with heDMTs (HR = 3.0; 95% CI = 1.2-7.1; p = 0.0013). To conclude, our data suggest a potential prognostic role of the KFLC-index during the MS course." @default.
- W4220786677 created "2022-04-03" @default.
- W4220786677 creator A5006458279 @default.
- W4220786677 creator A5007179321 @default.
- W4220786677 creator A5010071577 @default.
- W4220786677 creator A5015882829 @default.
- W4220786677 creator A5025930344 @default.
- W4220786677 creator A5027286857 @default.
- W4220786677 creator A5032470996 @default.
- W4220786677 creator A5037869698 @default.
- W4220786677 creator A5044241886 @default.
- W4220786677 creator A5051118910 @default.
- W4220786677 creator A5059496061 @default.
- W4220786677 creator A5062690727 @default.
- W4220786677 creator A5065748677 @default.
- W4220786677 creator A5072532110 @default.
- W4220786677 creator A5079195072 @default.
- W4220786677 creator A5087022404 @default.
- W4220786677 date "2022-03-07" @default.
- W4220786677 modified "2023-10-09" @default.
- W4220786677 title "High Levels of Cerebrospinal Fluid Kappa Free Light Chains Relate to IgM Intrathecal Synthesis and Might Have Prognostic Implications in Relapsing Multiple Sclerosis" @default.
- W4220786677 cites W1976005099 @default.
- W4220786677 cites W1983668865 @default.
- W4220786677 cites W1986889796 @default.
- W4220786677 cites W1991846128 @default.
- W4220786677 cites W2031694038 @default.
- W4220786677 cites W2050176801 @default.
- W4220786677 cites W2084866804 @default.
- W4220786677 cites W2094298397 @default.
- W4220786677 cites W2095979075 @default.
- W4220786677 cites W2118818657 @default.
- W4220786677 cites W2151454941 @default.
- W4220786677 cites W2160872052 @default.
- W4220786677 cites W2169159041 @default.
- W4220786677 cites W2614063182 @default.
- W4220786677 cites W2777074421 @default.
- W4220786677 cites W2792851064 @default.
- W4220786677 cites W2793475829 @default.
- W4220786677 cites W2913392021 @default.
- W4220786677 cites W2972689467 @default.
- W4220786677 cites W2985088294 @default.
- W4220786677 cites W2986476626 @default.
- W4220786677 cites W3008592094 @default.
- W4220786677 cites W3035297591 @default.
- W4220786677 cites W3047023088 @default.
- W4220786677 cites W3087234381 @default.
- W4220786677 cites W3120918985 @default.
- W4220786677 cites W3164619089 @default.
- W4220786677 cites W3165430172 @default.
- W4220786677 cites W3183511191 @default.
- W4220786677 cites W3198017924 @default.
- W4220786677 doi "https://doi.org/10.3389/fimmu.2022.827738" @default.
- W4220786677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35330910" @default.
- W4220786677 hasPublicationYear "2022" @default.
- W4220786677 type Work @default.
- W4220786677 citedByCount "5" @default.
- W4220786677 countsByYear W42207866772022 @default.
- W4220786677 countsByYear W42207866772023 @default.
- W4220786677 crossrefType "journal-article" @default.
- W4220786677 hasAuthorship W4220786677A5006458279 @default.
- W4220786677 hasAuthorship W4220786677A5007179321 @default.
- W4220786677 hasAuthorship W4220786677A5010071577 @default.
- W4220786677 hasAuthorship W4220786677A5015882829 @default.
- W4220786677 hasAuthorship W4220786677A5025930344 @default.
- W4220786677 hasAuthorship W4220786677A5027286857 @default.
- W4220786677 hasAuthorship W4220786677A5032470996 @default.
- W4220786677 hasAuthorship W4220786677A5037869698 @default.
- W4220786677 hasAuthorship W4220786677A5044241886 @default.
- W4220786677 hasAuthorship W4220786677A5051118910 @default.
- W4220786677 hasAuthorship W4220786677A5059496061 @default.
- W4220786677 hasAuthorship W4220786677A5062690727 @default.
- W4220786677 hasAuthorship W4220786677A5065748677 @default.
- W4220786677 hasAuthorship W4220786677A5072532110 @default.
- W4220786677 hasAuthorship W4220786677A5079195072 @default.
- W4220786677 hasAuthorship W4220786677A5087022404 @default.
- W4220786677 hasBestOaLocation W42207866771 @default.
- W4220786677 hasConcept C126322002 @default.
- W4220786677 hasConcept C138885662 @default.
- W4220786677 hasConcept C141071460 @default.
- W4220786677 hasConcept C157820659 @default.
- W4220786677 hasConcept C159654299 @default.
- W4220786677 hasConcept C167135981 @default.
- W4220786677 hasConcept C203014093 @default.
- W4220786677 hasConcept C207103383 @default.
- W4220786677 hasConcept C2778724333 @default.
- W4220786677 hasConcept C2779651940 @default.
- W4220786677 hasConcept C2780640218 @default.
- W4220786677 hasConcept C2780892749 @default.
- W4220786677 hasConcept C36394416 @default.
- W4220786677 hasConcept C38180746 @default.
- W4220786677 hasConcept C41895202 @default.
- W4220786677 hasConcept C44249647 @default.
- W4220786677 hasConcept C50382708 @default.
- W4220786677 hasConcept C71924100 @default.
- W4220786677 hasConcept C72563966 @default.
- W4220786677 hasConcept C90924648 @default.
- W4220786677 hasConceptScore W4220786677C126322002 @default.
- W4220786677 hasConceptScore W4220786677C138885662 @default.
- W4220786677 hasConceptScore W4220786677C141071460 @default.
- W4220786677 hasConceptScore W4220786677C157820659 @default.