FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220787060> ?p ?o ?g. }

• W4220787060 endingPage "894" @default.
• W4220787060 startingPage "883" @default.
• W4220787060 abstract "Recent work has established that SWI-independent-3 (SIN3) chromatin modification complexes play key roles in cancer progression. We previously demonstrated that knockdown of SIN3A expression promotes human breast cancer cell invasion and metastasis; however, the levels of SIN3A in patient breast carcinoma are not known. We therefore examined SIN3A mRNA and protein in patient tissues and determined that SIN3A expression is lower in breast carcinoma relative to normal breast. Given the 3'-untranslated region (UTR) of SIN3A has several conserved binding sites for oncogenic miRNA, we hypothesized that SIN3A is targeted by miRNA and found that ectopic miR-183 results in decreased SIN3A in breast carcinoma cell lines. Functionally, we demonstrate that miR-183 promotes breast cancer cell migration and invasion in a SIN3A-dependent manner and ectopic miR-183 promotes metastasis in vivo. Patients with breast cancer with high levels of miR-183 and low levels of SIN3A have the shortest overall survival. Given the critical link between metastasis and survival in patients with breast cancer, it is of utmost importance to identify clinically relevant genes involved in metastasis. Here, we report for the first time the aberrant expression of the putative metastasis suppressing gene SIN3A in human breast cancers and propose a mechanism of SIN3A suppression by miR-183.SIN3A expression is decreased in metastatic breast cancer in part due to miR-183." @default.
• W4220787060 created "2022-04-03" @default.
• W4220787060 creator A5007871170 @default.
• W4220787060 creator A5016193026 @default.
• W4220787060 creator A5027888832 @default.
• W4220787060 creator A5030996716 @default.
• W4220787060 creator A5052222320 @default.
• W4220787060 creator A5056324004 @default.
• W4220787060 creator A5058615793 @default.
• W4220787060 creator A5059421147 @default.
• W4220787060 creator A5070323809 @default.
• W4220787060 date "2022-03-01" @default.
• W4220787060 modified "2023-10-18" @default.
• W4220787060 title "Suppression of <i>SIN3A</i> by miR-183 Promotes Breast Cancer Metastasis" @default.
• W4220787060 cites W1536583711 @default.
• W4220787060 cites W1954905760 @default.
• W4220787060 cites W1975437957 @default.
• W4220787060 cites W1985092406 @default.
• W4220787060 cites W2013752850 @default.
• W4220787060 cites W2013758314 @default.
• W4220787060 cites W2050189729 @default.
• W4220787060 cites W2071412381 @default.
• W4220787060 cites W2073539157 @default.
• W4220787060 cites W2096209727 @default.
• W4220787060 cites W2110402883 @default.
• W4220787060 cites W2122595905 @default.
• W4220787060 cites W2125878906 @default.
• W4220787060 cites W2134629862 @default.
• W4220787060 cites W2164675798 @default.
• W4220787060 cites W2170618275 @default.
• W4220787060 cites W2171296186 @default.
• W4220787060 cites W2288757641 @default.
• W4220787060 cites W2322099019 @default.
• W4220787060 cites W2336531131 @default.
• W4220787060 cites W2413276850 @default.
• W4220787060 cites W2491374000 @default.
• W4220787060 cites W2514663093 @default.
• W4220787060 cites W2538285028 @default.
• W4220787060 cites W2742867475 @default.
• W4220787060 cites W2765894303 @default.
• W4220787060 cites W2796739357 @default.
• W4220787060 cites W2801348489 @default.
• W4220787060 cites W2804554615 @default.
• W4220787060 cites W2898502896 @default.
• W4220787060 cites W2905887518 @default.
• W4220787060 cites W2993309005 @default.
• W4220787060 cites W3082970451 @default.
• W4220787060 cites W3119005666 @default.
• W4220787060 doi "https://doi.org/10.1158/1541-7786.mcr-21-0508" @default.
• W4220787060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35247910" @default.
• W4220787060 hasPublicationYear "2022" @default.
• W4220787060 type Work @default.
• W4220787060 citedByCount "4" @default.
• W4220787060 countsByYear W42207870602022 @default.
• W4220787060 countsByYear W42207870602023 @default.
• W4220787060 crossrefType "journal-article" @default.
• W4220787060 hasAuthorship W4220787060A5007871170 @default.
• W4220787060 hasAuthorship W4220787060A5016193026 @default.
• W4220787060 hasAuthorship W4220787060A5027888832 @default.
• W4220787060 hasAuthorship W4220787060A5030996716 @default.
• W4220787060 hasAuthorship W4220787060A5052222320 @default.
• W4220787060 hasAuthorship W4220787060A5056324004 @default.
• W4220787060 hasAuthorship W4220787060A5058615793 @default.
• W4220787060 hasAuthorship W4220787060A5059421147 @default.
• W4220787060 hasAuthorship W4220787060A5070323809 @default.
• W4220787060 hasBestOaLocation W42207870601 @default.
• W4220787060 hasConcept C104317684 @default.
• W4220787060 hasConcept C121608353 @default.
• W4220787060 hasConcept C145059251 @default.
• W4220787060 hasConcept C173396325 @default.
• W4220787060 hasConcept C2779013556 @default.
• W4220787060 hasConcept C3018521938 @default.
• W4220787060 hasConcept C502942594 @default.
• W4220787060 hasConcept C530470458 @default.
• W4220787060 hasConcept C54355233 @default.
• W4220787060 hasConcept C86803240 @default.
• W4220787060 hasConcept C97037327 @default.
• W4220787060 hasConceptScore W4220787060C104317684 @default.
• W4220787060 hasConceptScore W4220787060C121608353 @default.
• W4220787060 hasConceptScore W4220787060C145059251 @default.
• W4220787060 hasConceptScore W4220787060C173396325 @default.
• W4220787060 hasConceptScore W4220787060C2779013556 @default.
• W4220787060 hasConceptScore W4220787060C3018521938 @default.
• W4220787060 hasConceptScore W4220787060C502942594 @default.
• W4220787060 hasConceptScore W4220787060C530470458 @default.
• W4220787060 hasConceptScore W4220787060C54355233 @default.
• W4220787060 hasConceptScore W4220787060C86803240 @default.
• W4220787060 hasConceptScore W4220787060C97037327 @default.
• W4220787060 hasIssue "6" @default.
• W4220787060 hasLocation W42207870601 @default.
• W4220787060 hasLocation W42207870602 @default.
• W4220787060 hasLocation W42207870603 @default.
• W4220787060 hasLocation W42207870604 @default.
• W4220787060 hasOpenAccess W4220787060 @default.
• W4220787060 hasPrimaryLocation W42207870601 @default.
• W4220787060 hasRelatedWork W1499339123 @default.
• W4220787060 hasRelatedWork W2054174996 @default.
• W4220787060 hasRelatedWork W2088061246 @default.

• next