FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220787514> ?p ?o ?g. }

• W4220787514 endingPage "1504" @default.
• W4220787514 startingPage "1495" @default.
• W4220787514 abstract "Alzheimer's disease (AD) co-pathology is common in dementia with Lewy bodies and is associated with increased decline. Plasma pTau181 is a blood-based biomarker that can detect AD co-pathology.We investigated whether pTau181 was associated with cognitive decline in mild cognitive impairment with Lewy bodies (MCI-LB) and MCI with AD (MCI-AD).We assessed plasma pTau181 using a single-molecule array (Simoa) immunoassay at baseline and follow-up in a longitudinal cohort of MCI-LB, MCI-AD, and controls.One hundred forty-six subjects (56 probable MCI-LB, 22 possible MCI-LB, 44 MCI-AD, and 24 controls) were reviewed for up to 5.7 years. Probable MCI-LB had significantly higher pTau181 (22.2% mean increase) compared with controls and significantly lower (24.4% mean decrease) levels compared with MCI-AD. Receiver operating characteristic analyses of pTau181 in discriminating probable MCI-LB from controls showed an area under the curve (AUC) of 0.68 (83% specificity, 57% sensitivity); for discriminating MCI-AD from healthy controls, AUC was 0.8 (83.3% specificity, 72.7% sensitivity). pTau181 concentration was less useful in discriminating between probable MCI-LB and MCI-AD: AUC of 0.64 (71.4% specificity, 52.3% sensitivity). There was an association between pTau181 and cognitive decline in MCI-AD but not in MCI-LB. In a subset with repeat samples there was a nonsignificant 3% increase per follow-up year in plasma pTau181. The rate of change in pTau181 was not significantly different in different diagnostic subgroups.pTau181 was not associated with an increased decline assessed using either baseline or repeat pTau181. pTau181 partially discriminated probable MCI-LB from controls and MCI-AD from controls but was not useful in distinguishing probable MCI-LB from MCI-AD. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society." @default.
• W4220787514 created "2022-04-03" @default.
• W4220787514 creator A5004869474 @default.
• W4220787514 creator A5008840640 @default.
• W4220787514 creator A5009178087 @default.
• W4220787514 creator A5014262891 @default.
• W4220787514 creator A5021309430 @default.
• W4220787514 creator A5027704222 @default.
• W4220787514 creator A5034270323 @default.
• W4220787514 creator A5035122709 @default.
• W4220787514 creator A5045246299 @default.
• W4220787514 creator A5067183224 @default.
• W4220787514 creator A5073721007 @default.
• W4220787514 creator A5077730818 @default.
• W4220787514 creator A5079766290 @default.
• W4220787514 creator A5082040813 @default.
• W4220787514 date "2022-03-23" @default.
• W4220787514 modified "2023-10-18" @default.
• W4220787514 title "A Longitudinal Study of Plasma <scp>pTau181</scp> in Mild Cognitive Impairment with Lewy Bodies and Alzheimer's Disease" @default.
• W4220787514 cites W2115017507 @default.
• W4220787514 cites W2121179979 @default.
• W4220787514 cites W2137422269 @default.
• W4220787514 cites W2141933000 @default.
• W4220787514 cites W2151689101 @default.
• W4220787514 cites W2151958260 @default.
• W4220787514 cites W2166263576 @default.
• W4220787514 cites W2292273527 @default.
• W4220787514 cites W2437089597 @default.
• W4220787514 cites W2574030000 @default.
• W4220787514 cites W2582524520 @default.
• W4220787514 cites W2589963787 @default.
• W4220787514 cites W2623521763 @default.
• W4220787514 cites W2765268397 @default.
• W4220787514 cites W2771599582 @default.
• W4220787514 cites W2974051306 @default.
• W4220787514 cites W2995668974 @default.
• W4220787514 cites W2997974303 @default.
• W4220787514 cites W3009441391 @default.
• W4220787514 cites W3018431352 @default.
• W4220787514 cites W3023694881 @default.
• W4220787514 cites W3036386775 @default.
• W4220787514 cites W3044633524 @default.
• W4220787514 cites W3045644607 @default.
• W4220787514 cites W3093943691 @default.
• W4220787514 cites W3095209702 @default.
• W4220787514 cites W3099667207 @default.
• W4220787514 cites W3111319985 @default.
• W4220787514 cites W3119309452 @default.
• W4220787514 cites W3133843610 @default.
• W4220787514 cites W3135124194 @default.
• W4220787514 cites W3137861752 @default.
• W4220787514 cites W3154164963 @default.
• W4220787514 cites W3164390524 @default.
• W4220787514 cites W3216057464 @default.
• W4220787514 doi "https://doi.org/10.1002/mds.28994" @default.
• W4220787514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35318733" @default.
• W4220787514 hasPublicationYear "2022" @default.
• W4220787514 type Work @default.
• W4220787514 citedByCount "7" @default.
• W4220787514 countsByYear W42207875142022 @default.
• W4220787514 countsByYear W42207875142023 @default.
• W4220787514 crossrefType "journal-article" @default.
• W4220787514 hasAuthorship W4220787514A5004869474 @default.
• W4220787514 hasAuthorship W4220787514A5008840640 @default.
• W4220787514 hasAuthorship W4220787514A5009178087 @default.
• W4220787514 hasAuthorship W4220787514A5014262891 @default.
• W4220787514 hasAuthorship W4220787514A5021309430 @default.
• W4220787514 hasAuthorship W4220787514A5027704222 @default.
• W4220787514 hasAuthorship W4220787514A5034270323 @default.
• W4220787514 hasAuthorship W4220787514A5035122709 @default.
• W4220787514 hasAuthorship W4220787514A5045246299 @default.
• W4220787514 hasAuthorship W4220787514A5067183224 @default.
• W4220787514 hasAuthorship W4220787514A5073721007 @default.
• W4220787514 hasAuthorship W4220787514A5077730818 @default.
• W4220787514 hasAuthorship W4220787514A5079766290 @default.
• W4220787514 hasAuthorship W4220787514A5082040813 @default.
• W4220787514 hasBestOaLocation W42207875142 @default.
• W4220787514 hasConcept C126322002 @default.
• W4220787514 hasConcept C142724271 @default.
• W4220787514 hasConcept C143998085 @default.
• W4220787514 hasConcept C15744967 @default.
• W4220787514 hasConcept C185592680 @default.
• W4220787514 hasConcept C2778548049 @default.
• W4220787514 hasConcept C2779134260 @default.
• W4220787514 hasConcept C2779483572 @default.
• W4220787514 hasConcept C2781197716 @default.
• W4220787514 hasConcept C2984863031 @default.
• W4220787514 hasConcept C2984915365 @default.
• W4220787514 hasConcept C502032728 @default.
• W4220787514 hasConcept C55493867 @default.
• W4220787514 hasConcept C58471807 @default.
• W4220787514 hasConcept C71924100 @default.
• W4220787514 hasConcept C72563966 @default.
• W4220787514 hasConcept C76318530 @default.
• W4220787514 hasConcept C90924648 @default.
• W4220787514 hasConceptScore W4220787514C126322002 @default.
• W4220787514 hasConceptScore W4220787514C142724271 @default.
• W4220787514 hasConceptScore W4220787514C143998085 @default.

• next