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• W4220787710 endingPage "549" @default.
• W4220787710 startingPage "541" @default.
• W4220787710 abstract "Cytotoxic CD8+ T cells are a key element of the adaptative immune system to protect the organism against infections and malignant cells. During their activation and response, T cells undergo different metabolic pathways to support their energetic needs according to their localization and function. However, it has also been recently appreciated that this metabolic reprogramming also directly supports T-cell lineage differentiation. Accordingly, metabolic deficiencies and prolonged stress exposure can impact T-cell differentiation and skew them into an exhausted state. Here, we review how metabolism defines CD8+ T-cell differentiation and function. Moreover, we cover the principal metabolic dysregulation that promotes the exhausted phenotype under tumor or chronic virus conditions. Finally, we summarize recent strategies to reprogram impaired metabolic pathways to promote CD8+ T-cell effector function and survival." @default.
• W4220787710 created "2022-04-03" @default.
• W4220787710 creator A5036489378 @default.
• W4220787710 creator A5045934445 @default.
• W4220787710 creator A5049298421 @default.
• W4220787710 date "2022-03-16" @default.
• W4220787710 modified "2023-10-10" @default.
• W4220787710 title "Metabolic dynamics instruct CD8⁺ T‐cell differentiation and functions" @default.
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• W4220787710 doi "https://doi.org/10.1002/eji.202149486" @default.
• W4220787710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35253907" @default.
• W4220787710 hasPublicationYear "2022" @default.
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