Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220787733> ?p ?o ?g. }
- W4220787733 endingPage "236" @default.
- W4220787733 startingPage "220" @default.
- W4220787733 abstract "Self-assembly of amphipathic styrene maleic acid copolymers with phospholipids in aqueous solution results in the formation of ‘nanodiscs’ containing a planar segment of phospholipid bilayer encapsulated by a polymer belt. Recently, studies have reported that lipids rapidly exchange between both nanodiscs in solution and external sources of lipids. Outstanding questions remain regarding details of polymer-lipid interactions, factors influencing lipid exchange and structural effects of such exchange processes. Here, the dynamic behaviour of nanodiscs is investigated, specifically the role of membrane charge and polymer chemistry. Two model systems are investigated: fluorescently labelled phospholipid vesicles, and Langmuir monolayers of phospholipids. Using fluorescence spectroscopy and time-resolved neutron reflectometry, the membrane potential, monolayer structure and composition are monitored with respect to time upon polymer and nanodisc interactions. In the presence of external lipids, polymer chains embed throughout lipid membranes, the extent of which is governed by the net membrane charge. Nanodiscs stabilised by three different polymers will all exchange lipids and polymer with monolayers to differing extents, related to the properties of the stabilising polymer belt. These results demonstrate the dynamic nature of nanodiscs which interact with the local environment and are likely to deposit both lipids and polymer at all stages of use." @default.
- W4220787733 created "2022-04-03" @default.
- W4220787733 creator A5002914756 @default.
- W4220787733 creator A5004063906 @default.
- W4220787733 creator A5025082802 @default.
- W4220787733 creator A5029342859 @default.
- W4220787733 creator A5041620475 @default.
- W4220787733 creator A5045216678 @default.
- W4220787733 creator A5050157916 @default.
- W4220787733 creator A5051160190 @default.
- W4220787733 creator A5060227303 @default.
- W4220787733 creator A5071277880 @default.
- W4220787733 date "2022-11-01" @default.
- W4220787733 modified "2023-10-16" @default.
- W4220787733 title "The interaction of styrene maleic acid copolymers with phospholipids in Langmuir monolayers, vesicles and nanodiscs; a structural study" @default.
- W4220787733 cites W1853656863 @default.
- W4220787733 cites W1990691888 @default.
- W4220787733 cites W2000714076 @default.
- W4220787733 cites W2008868458 @default.
- W4220787733 cites W2017041065 @default.
- W4220787733 cites W2024900979 @default.
- W4220787733 cites W2037081137 @default.
- W4220787733 cites W2057652020 @default.
- W4220787733 cites W2057653477 @default.
- W4220787733 cites W2089587226 @default.
- W4220787733 cites W2112877862 @default.
- W4220787733 cites W2114895447 @default.
- W4220787733 cites W2117349454 @default.
- W4220787733 cites W2145847261 @default.
- W4220787733 cites W2162850330 @default.
- W4220787733 cites W2311115706 @default.
- W4220787733 cites W2318293511 @default.
- W4220787733 cites W2369234542 @default.
- W4220787733 cites W2407998709 @default.
- W4220787733 cites W2409887094 @default.
- W4220787733 cites W2463509572 @default.
- W4220787733 cites W2518634075 @default.
- W4220787733 cites W2524092786 @default.
- W4220787733 cites W2531071156 @default.
- W4220787733 cites W2546951667 @default.
- W4220787733 cites W2547997755 @default.
- W4220787733 cites W2548237550 @default.
- W4220787733 cites W2573895878 @default.
- W4220787733 cites W2586024373 @default.
- W4220787733 cites W2587450560 @default.
- W4220787733 cites W2588088434 @default.
- W4220787733 cites W2604571273 @default.
- W4220787733 cites W2734328419 @default.
- W4220787733 cites W2736054689 @default.
- W4220787733 cites W2754872215 @default.
- W4220787733 cites W2755023530 @default.
- W4220787733 cites W2755372503 @default.
- W4220787733 cites W2758667808 @default.
- W4220787733 cites W2769585426 @default.
- W4220787733 cites W2770834937 @default.
- W4220787733 cites W2775805070 @default.
- W4220787733 cites W2778624787 @default.
- W4220787733 cites W2789666433 @default.
- W4220787733 cites W2790705492 @default.
- W4220787733 cites W2794539206 @default.
- W4220787733 cites W2802739845 @default.
- W4220787733 cites W2803466132 @default.
- W4220787733 cites W2808000708 @default.
- W4220787733 cites W2809186947 @default.
- W4220787733 cites W2811205622 @default.
- W4220787733 cites W2823734027 @default.
- W4220787733 cites W2894117653 @default.
- W4220787733 cites W2905101937 @default.
- W4220787733 cites W2911469881 @default.
- W4220787733 cites W2920967420 @default.
- W4220787733 cites W2951760581 @default.
- W4220787733 cites W2990909085 @default.
- W4220787733 cites W3003015667 @default.
- W4220787733 cites W3003265699 @default.
- W4220787733 cites W3012949518 @default.
- W4220787733 cites W3015826028 @default.
- W4220787733 cites W3019841737 @default.
- W4220787733 cites W3045190875 @default.
- W4220787733 cites W3089400930 @default.
- W4220787733 cites W3137337540 @default.
- W4220787733 cites W3161182887 @default.
- W4220787733 cites W3164867969 @default.
- W4220787733 cites W3199412415 @default.
- W4220787733 cites W4221125904 @default.
- W4220787733 cites W816578122 @default.
- W4220787733 doi "https://doi.org/10.1016/j.jcis.2022.03.102" @default.
- W4220787733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35716617" @default.
- W4220787733 hasPublicationYear "2022" @default.
- W4220787733 type Work @default.
- W4220787733 citedByCount "4" @default.
- W4220787733 countsByYear W42207877332022 @default.
- W4220787733 countsByYear W42207877332023 @default.
- W4220787733 crossrefType "journal-article" @default.
- W4220787733 hasAuthorship W4220787733A5002914756 @default.
- W4220787733 hasAuthorship W4220787733A5004063906 @default.
- W4220787733 hasAuthorship W4220787733A5025082802 @default.
- W4220787733 hasAuthorship W4220787733A5029342859 @default.
- W4220787733 hasAuthorship W4220787733A5041620475 @default.