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- W4220788502 abstract "Phase-transfer catalysis (PTC) is one of the most powerful catalytic manifolds for asymmetric synthesis. Chiral cationic or anionic PTC strategies have enabled a variety of transformations, yet studies on the use of insoluble inorganic salts as nucleophiles for the synthesis of enantioenriched molecules have remained elusive. A long-standing challenge is the development of methods for asymmetric carbon-fluorine bond formation from readily available and cost-effective alkali metal fluorides. In this Perspective, we describe how H-bond donors can provide a solution through fluoride binding. We use examples, primarily from our own research, to discuss how hydrogen bonding interactions impact fluoride reactivity and the role of H-bond donors as phase-transfer catalysts to bring solid-phase alkali metal fluorides in solution. These studies led to hydrogen bonding phase-transfer catalysis (HB-PTC), a new concept in PTC, originally crafted for alkali metal fluorides but offering opportunities beyond enantioselective fluorination. Looking ahead, the unlimited options that one can consider to diversify the H-bond donor, the inorganic salt, and the electrophile, herald a new era in phase-transfer catalysis. Whether abundant inorganic salts of lattice energy significantly higher than those studied to date could be considered as nucleophiles, e.g., CaF2, remains an open question, with solutions that may be found through synergistic PTC catalysis or beyond PTC." @default.
- W4220788502 created "2022-04-03" @default.
- W4220788502 creator A5034457900 @default.
- W4220788502 creator A5052546806 @default.
- W4220788502 date "2022-03-16" @default.
- W4220788502 modified "2023-09-30" @default.
- W4220788502 title "Hydrogen Bonding Phase-Transfer Catalysis with Alkali Metal Fluorides and Beyond" @default.
- W4220788502 cites W1924927508 @default.
- W4220788502 cites W1963623224 @default.
- W4220788502 cites W1964305404 @default.
- W4220788502 cites W1965449936 @default.
- W4220788502 cites W1974758589 @default.
- W4220788502 cites W1976424313 @default.
- W4220788502 cites W1976866491 @default.
- W4220788502 cites W1981814861 @default.
- W4220788502 cites W1982539812 @default.
- W4220788502 cites W1987401917 @default.
- W4220788502 cites W1988562282 @default.
- W4220788502 cites W1991147890 @default.
- W4220788502 cites W1993507339 @default.
- W4220788502 cites W1995677115 @default.
- W4220788502 cites W1998049497 @default.
- W4220788502 cites W2004654426 @default.
- W4220788502 cites W2017332198 @default.
- W4220788502 cites W2019538458 @default.
- W4220788502 cites W2023040593 @default.
- W4220788502 cites W2032089270 @default.
- W4220788502 cites W2032257982 @default.
- W4220788502 cites W2033556576 @default.
- W4220788502 cites W2034475135 @default.
- W4220788502 cites W2039193236 @default.
- W4220788502 cites W2046880515 @default.
- W4220788502 cites W2053112965 @default.
- W4220788502 cites W2056805429 @default.
- W4220788502 cites W2057509100 @default.
- W4220788502 cites W2063283966 @default.
- W4220788502 cites W2064303660 @default.
- W4220788502 cites W2065834277 @default.
- W4220788502 cites W2067857310 @default.
- W4220788502 cites W2068422331 @default.
- W4220788502 cites W2077102194 @default.
- W4220788502 cites W2079612070 @default.
- W4220788502 cites W2080434800 @default.
- W4220788502 cites W2082774852 @default.
- W4220788502 cites W2095617225 @default.
- W4220788502 cites W2095649875 @default.
- W4220788502 cites W2099925248 @default.
- W4220788502 cites W2104283415 @default.
- W4220788502 cites W2111695887 @default.
- W4220788502 cites W2112862862 @default.
- W4220788502 cites W2114466724 @default.
- W4220788502 cites W2115701502 @default.
- W4220788502 cites W2116087305 @default.
- W4220788502 cites W2116166338 @default.
- W4220788502 cites W2132032759 @default.
- W4220788502 cites W2133135526 @default.
- W4220788502 cites W2143298936 @default.
- W4220788502 cites W2148385329 @default.
- W4220788502 cites W2152960926 @default.
- W4220788502 cites W2157923062 @default.
- W4220788502 cites W2158974750 @default.
- W4220788502 cites W2172010059 @default.
- W4220788502 cites W2180629184 @default.
- W4220788502 cites W2263981172 @default.
- W4220788502 cites W2264719596 @default.
- W4220788502 cites W2280487965 @default.
- W4220788502 cites W2299621452 @default.
- W4220788502 cites W2314905383 @default.
- W4220788502 cites W2316492176 @default.
- W4220788502 cites W2319489245 @default.
- W4220788502 cites W2319646828 @default.
- W4220788502 cites W2326006968 @default.
- W4220788502 cites W2334721406 @default.
- W4220788502 cites W2410103223 @default.
- W4220788502 cites W2411068258 @default.
- W4220788502 cites W2510289573 @default.
- W4220788502 cites W2514191390 @default.
- W4220788502 cites W2567397185 @default.
- W4220788502 cites W2606917403 @default.
- W4220788502 cites W2749221743 @default.
- W4220788502 cites W2767817928 @default.
- W4220788502 cites W2772375513 @default.
- W4220788502 cites W2779444628 @default.
- W4220788502 cites W2785609333 @default.
- W4220788502 cites W2789933221 @default.
- W4220788502 cites W2792927639 @default.
- W4220788502 cites W2795534721 @default.
- W4220788502 cites W2799471671 @default.
- W4220788502 cites W2887447004 @default.
- W4220788502 cites W2911570773 @default.
- W4220788502 cites W2912961601 @default.
- W4220788502 cites W2950965966 @default.
- W4220788502 cites W2996323222 @default.
- W4220788502 cites W2999992244 @default.
- W4220788502 cites W3010565290 @default.
- W4220788502 cites W3011376102 @default.
- W4220788502 cites W3019266968 @default.
- W4220788502 cites W3021570698 @default.