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- W4220790004 abstract "Recurrent metastasis is a major fatal cause of breast cancer. Regretfully, the driving force and the molecular beneath have not been fully illustrated yet. In this study, a cohort of breast cancer patients with locoregional metastasis was recruited. For them, we collected the matched samples of the primary tumor and metastatic tumor, and then we determined the mutation profiles with whole-exome sequencing (WES). On basis of the profiles, we identified a list of deleterious variants in eight susceptible genes. Of them, filamin A (FLNA) was considered a potential driver gene of metastasis, and its low expression could enhance 5 years' relapse survival rate by 15%. To prove the finding, we constructed a stable FLNA knockout tumor cell line, which manifested that the cell abilities of proliferation, migration, and invasion were significantly weakened in response to the gene knockout. Subsequently, xenograft mouse experiments further proved that FLNA knockout could inhibit local or distal metastasis. Putting all the results together, we consolidated that FLNA could be a potential driver gene to metastasis of breast cancer, in particular triple-negative breast cancer. Additional experiments also suggested that FLNA might intervene in metastasis via the regulation of MMP-1 expression. In summary, this study demonstrates that FLNA may play as a positive regulator in cancer proliferation and recurrence. It provides new insight into breast cancer metastasis and suggests a potential new therapeutic target for breast cancer therapy." @default.
- W4220790004 created "2022-04-03" @default.
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- W4220790004 date "2022-03-11" @default.
- W4220790004 modified "2023-10-06" @default.
- W4220790004 title "Filamin A Is a Potential Driver of Breast Cancer Metastasis via Regulation of MMP-1" @default.
- W4220790004 cites W1271389891 @default.
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- W4220790004 cites W1966657242 @default.
- W4220790004 cites W1970413157 @default.
- W4220790004 cites W1984068087 @default.
- W4220790004 cites W1984326475 @default.
- W4220790004 cites W1984418041 @default.
- W4220790004 cites W1992437471 @default.
- W4220790004 cites W1995097523 @default.
- W4220790004 cites W1997196951 @default.
- W4220790004 cites W2014229457 @default.
- W4220790004 cites W2018893986 @default.
- W4220790004 cites W2022828121 @default.
- W4220790004 cites W2024345327 @default.
- W4220790004 cites W2025647419 @default.
- W4220790004 cites W2047425230 @default.
- W4220790004 cites W2078131718 @default.
- W4220790004 cites W2080063013 @default.
- W4220790004 cites W2086179251 @default.
- W4220790004 cites W2087963453 @default.
- W4220790004 cites W2089335658 @default.
- W4220790004 cites W2097893542 @default.
- W4220790004 cites W2100641827 @default.
- W4220790004 cites W2100867326 @default.
- W4220790004 cites W2103441770 @default.
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- W4220790004 cites W2108234281 @default.
- W4220790004 cites W2109372707 @default.
- W4220790004 cites W2111326065 @default.
- W4220790004 cites W2114029728 @default.
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- W4220790004 cites W2123230988 @default.
- W4220790004 cites W2127094853 @default.
- W4220790004 cites W2129952088 @default.
- W4220790004 cites W2131271579 @default.
- W4220790004 cites W2134539328 @default.
- W4220790004 cites W2142187664 @default.
- W4220790004 cites W2143238378 @default.
- W4220790004 cites W2145187337 @default.
- W4220790004 cites W2148105023 @default.
- W4220790004 cites W2149015358 @default.
- W4220790004 cites W2167264978 @default.
- W4220790004 cites W2173858545 @default.
- W4220790004 cites W2192080449 @default.
- W4220790004 cites W2207977286 @default.
- W4220790004 cites W2256016639 @default.
- W4220790004 cites W2535426958 @default.
- W4220790004 cites W2546921687 @default.
- W4220790004 cites W2555771555 @default.
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- W4220790004 cites W2577934600 @default.
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- W4220790004 cites W2779187290 @default.
- W4220790004 cites W2898234690 @default.
- W4220790004 cites W2931296773 @default.
- W4220790004 cites W2946213115 @default.
- W4220790004 cites W2965576600 @default.
- W4220790004 cites W2967901922 @default.
- W4220790004 cites W2980673911 @default.
- W4220790004 cites W2981263336 @default.
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- W4220790004 doi "https://doi.org/10.3389/fonc.2022.836126" @default.
- W4220790004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35359350" @default.
- W4220790004 hasPublicationYear "2022" @default.
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