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- W4220790767 abstract "Abstract Bipolar disorder is associated with substantial functional impairment, high health care costs, and premature mortality. The neurobiological mechanisms associated with bipolar disorder, however, are not well understood. In recent years, numerous studies about posttranscriptional regulation mechanisms have emerged in neuroscience. In this context, microRNAs (miRNAs), which belong to the noncoding RNA family and regulate gene expression via posttranscriptional mechanisms, have gained prominence. Their role in regulating the entire gene circuitry has provided a unique opportunity to characterize them at the genome-wide level and has stimulated investigators to scrutinize their involvement in disease pathogenesis and treatment response. Compared to other psychiatric illnesses, the studies of miRNAs in bipolar disorder are in the early stages; nevertheless, the results are quite encouraging and compel investigators to pursue more in-depth analyses using various approaches. The present chapter reviews miRNAs in the predictive validity of bipolar disorder pathogenesis, in the mechanisms of action of antimanic agents, and in their role as biomarkers of treatment response." @default.
- W4220790767 created "2022-04-03" @default.
- W4220790767 creator A5008149764 @default.
- W4220790767 date "2022-04-01" @default.
- W4220790767 modified "2023-09-26" @default.
- W4220790767 title "MiRNAs as predictors of bipolar disorder diagnosis and treatment response" @default.
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- W4220790767 doi "https://doi.org/10.1093/med/9780197574522.003.0012" @default.
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