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- W4220791856 abstract "Transforming growth factor-β (TGF-β) plays important roles in wound healing. The activity of TGF-β is initiated upon the binding of the growth factor to the extracellular domains of its receptors. We sought to facilitate the activation by clustering these extracellular domains. To do so, we used a known peptide that binds to TGF-β receptors without diminishing their affinity for TGF-β. We conjugated this peptide to a collagen-mimetic peptide that can anneal to the damaged collagen in a wound bed. We find that the conjugate enhances collagen deposition and wound closure in mice in a manner consistent with the clustering of TGF-β receptors. This strategy provides a means to upregulate the TGF-β signaling pathway without adding exogenous TGF-β and could inspire means to treat severe wounds." @default.
- W4220791856 created "2022-04-03" @default.
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- W4220791856 creator A5085428806 @default.
- W4220791856 creator A5088907274 @default.
- W4220791856 date "2022-01-27" @default.
- W4220791856 modified "2023-10-18" @default.
- W4220791856 title "Bifunctional Peptide that Anneals to Damaged Collagen and Clusters TGF-β Receptors Enhances Wound Healing" @default.
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- W4220791856 doi "https://doi.org/10.1021/acschembio.1c00745" @default.
- W4220791856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35084170" @default.
- W4220791856 hasPublicationYear "2022" @default.
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