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• W4220793071 abstract "The genome streamlining theory suggests that reduction of microbial genome size optimizes energy utilization in stressful environments. Although this hypothesis has been explored in several cases of low-nutrient (oligotrophic) and high-temperature environments, little work has been carried out on microorganisms from low-pH environments, and what has been reported is inconclusive. In this study, we performed a large-scale comparative genomics investigation of more than 260 bacterial high-quality genome sequences of acidophiles, together with genomes of their closest phylogenetic relatives that live at circum-neutral pH. A statistically supported correlation is reported between reduction of genome size and decreasing pH that we demonstrate is due to gene loss and reduced gene sizes. This trend is independent from other genome size constraints such as temperature and G + C content. Genome streamlining in the evolution of acidophilic bacteria is thus supported by our results. The analyses of predicted Clusters of Orthologous Genes (COG) categories and subcellular location predictions indicate that acidophiles have a lower representation of genes encoding extracellular proteins, signal transduction mechanisms, and proteins with unknown function but are enriched in inner membrane proteins, chaperones, basic metabolism, and core cellular functions. Contrary to other reports for genome streamlining, there was no significant change in paralog frequencies across pH. However, a detailed analysis of COG categories revealed a higher proportion of genes in acidophiles in the following categories: replication and repair, amino acid transport, and intracellular trafficking. This study brings increasing clarity regarding the genomic adaptations of acidophiles to life at low pH while putting elements, such as the reduction of average gene size, under the spotlight of streamlining theory." @default.
• W4220793071 created "2022-04-03" @default.
• W4220793071 creator A5041456165 @default.
• W4220793071 creator A5046504376 @default.
• W4220793071 creator A5052449406 @default.
• W4220793071 creator A5054079058 @default.
• W4220793071 creator A5078704965 @default.
• W4220793071 date "2022-03-21" @default.
• W4220793071 modified "2023-09-26" @default.
• W4220793071 title "A Large-Scale Genome-Based Survey of Acidophilic Bacteria Suggests That Genome Streamlining Is an Adaption for Life at Low pH" @default.
• W4220793071 cites W1162644523 @default.
• W4220793071 cites W1163977700 @default.
• W4220793071 cites W1517466915 @default.
• W4220793071 cites W1579194849 @default.
• W4220793071 cites W1967694965 @default.
• W4220793071 cites W1969224299 @default.
• W4220793071 cites W1969827977 @default.
• W4220793071 cites W1984112966 @default.
• W4220793071 cites W1985818080 @default.
• W4220793071 cites W1988678841 @default.
• W4220793071 cites W1989687753 @default.
• W4220793071 cites W1989997854 @default.
• W4220793071 cites W1998752502 @default.
• W4220793071 cites W2000618501 @default.
• W4220793071 cites W2002823903 @default.
• W4220793071 cites W2004254961 @default.
• W4220793071 cites W2011301426 @default.
• W4220793071 cites W2011967714 @default.
• W4220793071 cites W2012003686 @default.
• W4220793071 cites W2012720430 @default.
• W4220793071 cites W2013971322 @default.
• W4220793071 cites W2013998951 @default.
• W4220793071 cites W2014422859 @default.
• W4220793071 cites W2017221574 @default.
• W4220793071 cites W2017335389 @default.
• W4220793071 cites W2017911769 @default.
• W4220793071 cites W2018526864 @default.
• W4220793071 cites W2021627231 @default.
• W4220793071 cites W2027382501 @default.
• W4220793071 cites W2030742563 @default.
• W4220793071 cites W2036906015 @default.
• W4220793071 cites W2038464976 @default.
• W4220793071 cites W2054878678 @default.
• W4220793071 cites W2056399133 @default.
• W4220793071 cites W2057568778 @default.
• W4220793071 cites W2067872462 @default.
• W4220793071 cites W2075680815 @default.
• W4220793071 cites W2077337646 @default.
• W4220793071 cites W2079151120 @default.
• W4220793071 cites W2092604303 @default.
• W4220793071 cites W2093882865 @default.
• W4220793071 cites W2095172074 @default.
• W4220793071 cites W2095449747 @default.
• W4220793071 cites W2096093282 @default.
• W4220793071 cites W2099571549 @default.
• W4220793071 cites W2103585651 @default.
• W4220793071 cites W2110065044 @default.
• W4220793071 cites W2112364185 @default.
• W4220793071 cites W2113273019 @default.
• W4220793071 cites W2113350312 @default.
• W4220793071 cites W2119489506 @default.
• W4220793071 cites W2120445687 @default.
• W4220793071 cites W2121055398 @default.
• W4220793071 cites W2122319775 @default.
• W4220793071 cites W2127132269 @default.
• W4220793071 cites W2127751528 @default.
• W4220793071 cites W2129168664 @default.
• W4220793071 cites W2131281388 @default.
• W4220793071 cites W2132496668 @default.
• W4220793071 cites W2132870251 @default.
• W4220793071 cites W2133917399 @default.
• W4220793071 cites W2134201593 @default.
• W4220793071 cites W2136632285 @default.
• W4220793071 cites W2137475545 @default.
• W4220793071 cites W2138361239 @default.
• W4220793071 cites W2139183861 @default.
• W4220793071 cites W2140709908 @default.
• W4220793071 cites W2143919288 @default.
• W4220793071 cites W2144792423 @default.
• W4220793071 cites W2146008744 @default.
• W4220793071 cites W2147414892 @default.
• W4220793071 cites W2150550043 @default.
• W4220793071 cites W2153572376 @default.
• W4220793071 cites W2162792752 @default.
• W4220793071 cites W2167188257 @default.
• W4220793071 cites W2167877584 @default.
• W4220793071 cites W2171706806 @default.
• W4220793071 cites W2224056471 @default.
• W4220793071 cites W2230300757 @default.
• W4220793071 cites W2243605584 @default.
• W4220793071 cites W2253528435 @default.
• W4220793071 cites W2287701396 @default.
• W4220793071 cites W2308113567 @default.
• W4220793071 cites W2308145610 @default.
• W4220793071 cites W2409930878 @default.
• W4220793071 cites W2467063962 @default.
• W4220793071 cites W2504995927 @default.
• W4220793071 cites W2505229594 @default.
• W4220793071 cites W2521334340 @default.
• W4220793071 cites W2523188367 @default.

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