Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220793455> ?p ?o ?g. }
- W4220793455 endingPage "103688" @default.
- W4220793455 startingPage "103688" @default.
- W4220793455 abstract "Short open reading frame (sORF)-encoded peptides (sPEPs) have been found across a wide range of genomic locations in a variety of species. To date, their identification, validation, and characterisation in the human fungal pathogen Cryptococcus neoformans has been limited due to a lack of standardised protocols. We have developed an enrichment process that enables sPEP detection within a protein sample from this polysaccharide-encapsulated yeast, and implemented proteogenomics to provide insights into the validity of predicted and hypothetical sORFs annotated in the C. neoformans genome. Novel sORFs were discovered within the 5' and 3' UTRs of known transcripts as well as in non-coding RNAs. One novel candidate, dubbed NPB1, that resided in an RNA annotated as non-coding, was chosen for characterisation. Through the creation of both specific point mutations and a full deletion allele, the function of the new sPEP, Npb1, was shown to resemble that of the bacterial trans-translation protein SmpB." @default.
- W4220793455 created "2022-04-03" @default.
- W4220793455 creator A5004300103 @default.
- W4220793455 creator A5017990514 @default.
- W4220793455 creator A5031381367 @default.
- W4220793455 creator A5065433879 @default.
- W4220793455 creator A5071580241 @default.
- W4220793455 creator A5080285308 @default.
- W4220793455 creator A5086644034 @default.
- W4220793455 date "2022-05-01" @default.
- W4220793455 modified "2023-10-17" @default.
- W4220793455 title "Identification and characterisation of sPEPs in Cryptococcus neoformans" @default.
- W4220793455 cites W1555645785 @default.
- W4220793455 cites W1803102843 @default.
- W4220793455 cites W1979544330 @default.
- W4220793455 cites W1981593008 @default.
- W4220793455 cites W1996104434 @default.
- W4220793455 cites W2003861150 @default.
- W4220793455 cites W2015009994 @default.
- W4220793455 cites W2021341670 @default.
- W4220793455 cites W2025905237 @default.
- W4220793455 cites W2029173942 @default.
- W4220793455 cites W2041882488 @default.
- W4220793455 cites W2061004320 @default.
- W4220793455 cites W2063324492 @default.
- W4220793455 cites W2076652419 @default.
- W4220793455 cites W2078190145 @default.
- W4220793455 cites W2078266900 @default.
- W4220793455 cites W2079843936 @default.
- W4220793455 cites W2081465448 @default.
- W4220793455 cites W2082120419 @default.
- W4220793455 cites W2098472248 @default.
- W4220793455 cites W2098716124 @default.
- W4220793455 cites W2100424218 @default.
- W4220793455 cites W2102431286 @default.
- W4220793455 cites W2103286668 @default.
- W4220793455 cites W2103937512 @default.
- W4220793455 cites W2110728577 @default.
- W4220793455 cites W2114165700 @default.
- W4220793455 cites W2118868063 @default.
- W4220793455 cites W2124779706 @default.
- W4220793455 cites W2126926134 @default.
- W4220793455 cites W2135581618 @default.
- W4220793455 cites W2138255346 @default.
- W4220793455 cites W2146341019 @default.
- W4220793455 cites W2152358678 @default.
- W4220793455 cites W2157401644 @default.
- W4220793455 cites W2163865644 @default.
- W4220793455 cites W2168517773 @default.
- W4220793455 cites W2309998549 @default.
- W4220793455 cites W2336846619 @default.
- W4220793455 cites W2522950276 @default.
- W4220793455 cites W2558158323 @default.
- W4220793455 cites W2582077910 @default.
- W4220793455 cites W2605835384 @default.
- W4220793455 cites W2755251026 @default.
- W4220793455 cites W2768421721 @default.
- W4220793455 cites W2770089238 @default.
- W4220793455 cites W2789857505 @default.
- W4220793455 cites W2793153410 @default.
- W4220793455 cites W2802279743 @default.
- W4220793455 cites W2897867064 @default.
- W4220793455 cites W2899250708 @default.
- W4220793455 cites W2901584955 @default.
- W4220793455 cites W2914192686 @default.
- W4220793455 cites W2917341168 @default.
- W4220793455 cites W2921207335 @default.
- W4220793455 cites W2942901128 @default.
- W4220793455 cites W2946448303 @default.
- W4220793455 cites W2949523281 @default.
- W4220793455 cites W2988240595 @default.
- W4220793455 cites W3004957522 @default.
- W4220793455 cites W3009646777 @default.
- W4220793455 cites W3009675335 @default.
- W4220793455 cites W3010001459 @default.
- W4220793455 cites W3016548801 @default.
- W4220793455 doi "https://doi.org/10.1016/j.fgb.2022.103688" @default.
- W4220793455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35339703" @default.
- W4220793455 hasPublicationYear "2022" @default.
- W4220793455 type Work @default.
- W4220793455 citedByCount "0" @default.
- W4220793455 crossrefType "journal-article" @default.
- W4220793455 hasAuthorship W4220793455A5004300103 @default.
- W4220793455 hasAuthorship W4220793455A5017990514 @default.
- W4220793455 hasAuthorship W4220793455A5031381367 @default.
- W4220793455 hasAuthorship W4220793455A5065433879 @default.
- W4220793455 hasAuthorship W4220793455A5071580241 @default.
- W4220793455 hasAuthorship W4220793455A5080285308 @default.
- W4220793455 hasAuthorship W4220793455A5086644034 @default.
- W4220793455 hasConcept C104317684 @default.
- W4220793455 hasConcept C141231307 @default.
- W4220793455 hasConcept C145741570 @default.
- W4220793455 hasConcept C167625842 @default.
- W4220793455 hasConcept C189206191 @default.
- W4220793455 hasConcept C2777893358 @default.
- W4220793455 hasConcept C2778952914 @default.
- W4220793455 hasConcept C47289529 @default.
- W4220793455 hasConcept C54355233 @default.