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• W4220793759 abstract "NTRK fusions drive oncogenesis in a variety of adult cancers. The approval of the first-generation TRK inhibitors, larotrectinib and entrectinib, for any cancer with an NTRK fusion represented a focal point in tumor-agnostic drug development. These agents achieve high response rates and durable disease control, and display intracranial activity. The use of these agents has resulted in a deeper understanding of the clinical consequences of TRK inhibition. These on-target side effects include dizziness, weight gain, and withdrawal pain. The study of TRK inhibitor resistance led to the development of next generation drugs, such as selitrectinib, repotrectinib, taletrectinib, and other agents that maintain disease control against selected acquired kinase domain mutations. This review discusses the clinical efficacy of TRK inhibitors, their safety profiles, and resistance mechanisms with a focus on data in adult cancers." @default.
• W4220793759 created "2022-04-03" @default.
• W4220793759 creator A5006571734 @default.
• W4220793759 creator A5063199354 @default.
• W4220793759 date "2022-06-01" @default.
• W4220793759 modified "2023-09-30" @default.
• W4220793759 title "TRK inhibitor activity and resistance in TRK fusion-positive cancers in adults" @default.
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• W4220793759 doi "https://doi.org/10.1016/j.cancergen.2022.03.002" @default.
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