FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220793882> ?p ?o ?g. }

• W4220793882 abstract "Local anesthetics with long-lasting effects and selectivity for nociceptors have been sought over the past decades. In this study, we investigated whether amiodarone, a multiple channel blocker, provides long-lasting local anesthesia and whether adding a TRPV1 channel activator selectively prolongs sensory anesthetic effects without prolonging motor blockade. Additionally, we examined whether amiodarone provides long-lasting analgesic effects against inflammatory pain without TRPV1 channel activator co-administration. In the sciatic nerve block model, 32 adult C57BL/6J mice received either bupivacaine, amiodarone with or without capsaicin (a TRPV1 agonist), or vehicle via peri-sciatic nerve injection. Sensory and motor blockade were assessed either by pinprick and toe spread tests, respectively. In another set of 16 mice, inflammatory pain was induced in the hind paw by zymosan injection, followed by administration of either amiodarone or vehicle. Mechanical and thermal sensitivity and paw thickness were assessed using the von Frey and Hargreaves tests, respectively. The possible cardiovascular and neurological side effects of local amiodarone injection were assessed in another set of 12 mice. In the sciatic nerve block model, amiodarone produced robust anesthesia, and the co-administration of TRPV1 agonist capsaicin prolonged the duration of sensory blockade, but not that of motor blockade [complete sensory block duration: 195.0 ± 9.8 min vs. 28.8 ± 1.3 min, F (2, 21) = 317.6, p < 0.01, complete motor block duration: 27.5 ± 1.6 min vs. 21.3 ± 2.3 min, F (2, 22) = 11.1, p = 0.0695]. In the zymosan-induced inflammatory pain model, low-dose amiodarone was effective in reversing the mechanical and thermal hypersensitivity not requiring capsaicin co-administration [50% withdrawal threshold at 8 h (g): 0.85 ± 0.09 vs. 0.25 ± 0.08, p < 0.01, withdrawal latency at 4 h (s) 8.5 ± 0.5 vs. 5.7 ± 1.4, p < 0.05]. Low-dose amiodarone did not affect zymosan-induced paw inflammation. Local amiodarone did not cause cardiovascular or central nervous system side effects. Amiodarone may have the potential to be a long-acting and nociceptor-selective local anesthetic and analgesic method acting over open-state large-pore channels." @default.
• W4220793882 created "2022-04-03" @default.
• W4220793882 creator A5001217608 @default.
• W4220793882 creator A5008126485 @default.
• W4220793882 creator A5009327401 @default.
• W4220793882 creator A5053761554 @default.
• W4220793882 creator A5067717998 @default.
• W4220793882 creator A5074122274 @default.
• W4220793882 creator A5085391531 @default.
• W4220793882 date "2022-03-18" @default.
• W4220793882 modified "2023-10-14" @default.
• W4220793882 title "Amiodarone Provides Long-Lasting Local Anesthesia and Analgesia in Open-State Mouse Nociceptors" @default.
• W4220793882 cites W1585790473 @default.
• W4220793882 cites W1596924664 @default.
• W4220793882 cites W1971459402 @default.
• W4220793882 cites W2022652178 @default.
• W4220793882 cites W2023213874 @default.
• W4220793882 cites W2040827718 @default.
• W4220793882 cites W2040927330 @default.
• W4220793882 cites W2047937742 @default.
• W4220793882 cites W2103351070 @default.
• W4220793882 cites W2105469906 @default.
• W4220793882 cites W2110243945 @default.
• W4220793882 cites W2112163451 @default.
• W4220793882 cites W2121836743 @default.
• W4220793882 cites W2124798906 @default.
• W4220793882 cites W2144832875 @default.
• W4220793882 cites W2168210103 @default.
• W4220793882 cites W2170982145 @default.
• W4220793882 cites W2409950447 @default.
• W4220793882 cites W2770068524 @default.
• W4220793882 cites W2800508734 @default.
• W4220793882 cites W2894329539 @default.
• W4220793882 cites W2948753093 @default.
• W4220793882 cites W2980961929 @default.
• W4220793882 cites W2991162290 @default.
• W4220793882 cites W2994216830 @default.
• W4220793882 cites W3003226602 @default.
• W4220793882 cites W3042566401 @default.
• W4220793882 cites W3161802642 @default.
• W4220793882 cites W3211845012 @default.
• W4220793882 doi "https://doi.org/10.3389/fphar.2022.872477" @default.
• W4220793882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35370742" @default.
• W4220793882 hasPublicationYear "2022" @default.
• W4220793882 type Work @default.
• W4220793882 citedByCount "0" @default.
• W4220793882 crossrefType "journal-article" @default.
• W4220793882 hasAuthorship W4220793882A5001217608 @default.
• W4220793882 hasAuthorship W4220793882A5008126485 @default.
• W4220793882 hasAuthorship W4220793882A5009327401 @default.
• W4220793882 hasAuthorship W4220793882A5053761554 @default.
• W4220793882 hasAuthorship W4220793882A5067717998 @default.
• W4220793882 hasAuthorship W4220793882A5074122274 @default.
• W4220793882 hasAuthorship W4220793882A5085391531 @default.
• W4220793882 hasBestOaLocation W42207938821 @default.
• W4220793882 hasConcept C104211972 @default.
• W4220793882 hasConcept C126322002 @default.
• W4220793882 hasConcept C15490471 @default.
• W4220793882 hasConcept C155164980 @default.
• W4220793882 hasConcept C160145004 @default.
• W4220793882 hasConcept C168481208 @default.
• W4220793882 hasConcept C170493617 @default.
• W4220793882 hasConcept C172659308 @default.
• W4220793882 hasConcept C2778094803 @default.
• W4220793882 hasConcept C2778468042 @default.
• W4220793882 hasConcept C2778938600 @default.
• W4220793882 hasConcept C2778994108 @default.
• W4220793882 hasConcept C2779161974 @default.
• W4220793882 hasConcept C2780051329 @default.
• W4220793882 hasConcept C2780820201 @default.
• W4220793882 hasConcept C2781149210 @default.
• W4220793882 hasConcept C42219234 @default.
• W4220793882 hasConcept C71924100 @default.
• W4220793882 hasConcept C98274493 @default.
• W4220793882 hasConceptScore W4220793882C104211972 @default.
• W4220793882 hasConceptScore W4220793882C126322002 @default.
• W4220793882 hasConceptScore W4220793882C15490471 @default.
• W4220793882 hasConceptScore W4220793882C155164980 @default.
• W4220793882 hasConceptScore W4220793882C160145004 @default.
• W4220793882 hasConceptScore W4220793882C168481208 @default.
• W4220793882 hasConceptScore W4220793882C170493617 @default.
• W4220793882 hasConceptScore W4220793882C172659308 @default.
• W4220793882 hasConceptScore W4220793882C2778094803 @default.
• W4220793882 hasConceptScore W4220793882C2778468042 @default.
• W4220793882 hasConceptScore W4220793882C2778938600 @default.
• W4220793882 hasConceptScore W4220793882C2778994108 @default.
• W4220793882 hasConceptScore W4220793882C2779161974 @default.
• W4220793882 hasConceptScore W4220793882C2780051329 @default.
• W4220793882 hasConceptScore W4220793882C2780820201 @default.
• W4220793882 hasConceptScore W4220793882C2781149210 @default.
• W4220793882 hasConceptScore W4220793882C42219234 @default.
• W4220793882 hasConceptScore W4220793882C71924100 @default.
• W4220793882 hasConceptScore W4220793882C98274493 @default.
• W4220793882 hasFunder F4320334764 @default.
• W4220793882 hasLocation W42207938821 @default.
• W4220793882 hasLocation W42207938822 @default.
• W4220793882 hasLocation W42207938823 @default.
• W4220793882 hasLocation W42207938824 @default.
• W4220793882 hasOpenAccess W4220793882 @default.
• W4220793882 hasPrimaryLocation W42207938821 @default.

• next