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- W4220794290 abstract "Macrophages are central elements of all organs, where they have a multitude of physiological and pathological functions. The first macrophages are produced during fetal development, and most adult organs retain populations of fetal-derived macrophages that self-maintain without major input of hematopoietic stem cell-derived monocytes. Their developmental origins make macrophages highly susceptible to environmental perturbations experienced in early life, in particular the fetal period. It is now well recognized that such adverse developmental conditions contribute to a wide range of diseases later in life. This chapter explores the notion that macrophages are key targets of environmental adversities during development, and mediators of their long-term impact on health and disease. We first briefly summarize our current understanding of macrophage ontogeny and their biology in tissues and consider potential mechanisms by which environmental stressors may mediate fetal programming. We then review evidence for programming of macrophages by adversities ranging from maternal immune activation and diet to environmental pollutants and toxins, which have disease relevance for different organ systems. Throughout this chapter, we contemplate appropriate experimental strategies to study macrophage programming. We conclude by discussing how our current knowledge of macrophage programming could be conceptualized, and finally highlight open questions in the field and approaches to address them." @default.
- W4220794290 created "2022-04-03" @default.
- W4220794290 creator A5000607389 @default.
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- W4220794290 creator A5044582549 @default.
- W4220794290 creator A5080061070 @default.
- W4220794290 date "2022-01-01" @default.
- W4220794290 modified "2023-10-13" @default.
- W4220794290 title "Developmental programming of macrophages by early life adversity" @default.
- W4220794290 cites W1574848475 @default.
- W4220794290 cites W1579115151 @default.
- W4220794290 cites W1588611448 @default.
- W4220794290 cites W1683908058 @default.
- W4220794290 cites W1797422316 @default.
- W4220794290 cites W1844666621 @default.
- W4220794290 cites W1937332911 @default.
- W4220794290 cites W1954497589 @default.
- W4220794290 cites W1964506812 @default.
- W4220794290 cites W1967211742 @default.
- W4220794290 cites W1967640708 @default.
- W4220794290 cites W1969470394 @default.
- W4220794290 cites W1969944303 @default.
- W4220794290 cites W1970760886 @default.
- W4220794290 cites W1971650842 @default.
- W4220794290 cites W1973433801 @default.
- W4220794290 cites W1975941236 @default.
- W4220794290 cites W1977536320 @default.
- W4220794290 cites W1983448585 @default.
- W4220794290 cites W1984554199 @default.
- W4220794290 cites W1984574450 @default.
- W4220794290 cites W1985774052 @default.
- W4220794290 cites W1990565971 @default.
- W4220794290 cites W1998159392 @default.
- W4220794290 cites W1999202036 @default.
- W4220794290 cites W2000199690 @default.
- W4220794290 cites W2001082893 @default.
- W4220794290 cites W2003024378 @default.
- W4220794290 cites W2003677779 @default.
- W4220794290 cites W2010484682 @default.
- W4220794290 cites W2010876644 @default.
- W4220794290 cites W2011096612 @default.
- W4220794290 cites W2018767461 @default.
- W4220794290 cites W2020651859 @default.
- W4220794290 cites W2023666964 @default.
- W4220794290 cites W2024190010 @default.
- W4220794290 cites W2024894183 @default.
- W4220794290 cites W2025162592 @default.
- W4220794290 cites W2031603575 @default.
- W4220794290 cites W2032266027 @default.
- W4220794290 cites W2032951893 @default.
- W4220794290 cites W2035672333 @default.
- W4220794290 cites W2037506901 @default.
- W4220794290 cites W2044315491 @default.
- W4220794290 cites W2044569441 @default.
- W4220794290 cites W2045311674 @default.
- W4220794290 cites W2046357173 @default.
- W4220794290 cites W2048258021 @default.
- W4220794290 cites W2050776663 @default.
- W4220794290 cites W2052110191 @default.
- W4220794290 cites W2054540776 @default.
- W4220794290 cites W2056456647 @default.
- W4220794290 cites W2057949930 @default.
- W4220794290 cites W2060753137 @default.
- W4220794290 cites W2066072238 @default.
- W4220794290 cites W2067401763 @default.
- W4220794290 cites W2068630231 @default.
- W4220794290 cites W2070936810 @default.
- W4220794290 cites W2074299988 @default.
- W4220794290 cites W2074319917 @default.
- W4220794290 cites W2075153512 @default.
- W4220794290 cites W2078011109 @default.
- W4220794290 cites W2087101282 @default.
- W4220794290 cites W2089249520 @default.
- W4220794290 cites W2091487793 @default.
- W4220794290 cites W2094031116 @default.
- W4220794290 cites W2096179876 @default.
- W4220794290 cites W2098440133 @default.
- W4220794290 cites W2100646399 @default.
- W4220794290 cites W2103392131 @default.
- W4220794290 cites W2105772435 @default.
- W4220794290 cites W2108800680 @default.
- W4220794290 cites W2115116599 @default.
- W4220794290 cites W2121291228 @default.
- W4220794290 cites W2124841332 @default.
- W4220794290 cites W2125323728 @default.
- W4220794290 cites W2126138300 @default.
- W4220794290 cites W2126263479 @default.
- W4220794290 cites W2126811287 @default.
- W4220794290 cites W2131017300 @default.
- W4220794290 cites W2132092970 @default.
- W4220794290 cites W2133351125 @default.
- W4220794290 cites W2134574297 @default.
- W4220794290 cites W2134842383 @default.
- W4220794290 cites W2135496473 @default.
- W4220794290 cites W2140380746 @default.
- W4220794290 cites W2141645427 @default.
- W4220794290 cites W2142242761 @default.
- W4220794290 cites W2148898943 @default.