FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220794948> ?p ?o ?g. }

• W4220794948 abstract "The relative contribution of selection and neutrality in shaping species genetic diversity is one of the most central and controversial questions in evolutionary theory. Genomic data provide growing evidence that linked selection, i.e. the modification of genetic diversity at neutral sites through linkage with selected sites, might be pervasive over the genome. Several studies proposed that linked selection could be modeled as first approximation by a local reduction (e.g. purifying selection, selective sweeps) or increase (e.g. balancing selection) of effective population size (Ne). At the genome-wide scale, this leads to variations of Ne from one region to another, reflecting the heterogeneity of selective constraints and recombination rates between regions. We investigate here the consequences of such genomic variations of Ne on the genome-wide distribution of coalescence times. The underlying motivation concerns the impact of linked selection on demographic inference, because the distribution of coalescence times is at the heart of several important demographic inference approaches. Using the concept of inverse instantaneous coalescence rate, we demonstrate that in a panmictic population, linked selection always results in a spurious apparent decrease of Ne along time. Balancing selection has a particularly large effect, even when it concerns a very small part of the genome. We also study more general models including genuine population size changes, population structure or transient selection and find that the effect of linked selection can be significantly reduced by that of population structure. The models and conclusions presented here are also relevant to the study of other biological processes generating apparent variations of Ne along the genome." @default.
• W4220794948 created "2022-04-03" @default.
• W4220794948 creator A5004699011 @default.
• W4220794948 creator A5018561698 @default.
• W4220794948 creator A5018787679 @default.
• W4220794948 creator A5018816923 @default.
• W4220794948 date "2022-01-20" @default.
• W4220794948 modified "2023-10-18" @default.
• W4220794948 title "Heterogeneity in effective size across the genome: effects on the inverse instantaneous coalescence rate (IICR) and implications for demographic inference under linked selection" @default.
• W4220794948 cites W1772281102 @default.
• W4220794948 cites W1941027263 @default.
• W4220794948 cites W1964224776 @default.
• W4220794948 cites W2046799846 @default.
• W4220794948 cites W2091705028 @default.
• W4220794948 cites W2107021548 @default.
• W4220794948 cites W2109195195 @default.
• W4220794948 cites W2116067961 @default.
• W4220794948 cites W2118020384 @default.
• W4220794948 cites W2125300654 @default.
• W4220794948 cites W2125375261 @default.
• W4220794948 cites W2126204254 @default.
• W4220794948 cites W2134599124 @default.
• W4220794948 cites W2144658220 @default.
• W4220794948 cites W2152832004 @default.
• W4220794948 cites W2155670634 @default.
• W4220794948 cites W2173518071 @default.
• W4220794948 cites W2190140475 @default.
• W4220794948 cites W2289445866 @default.
• W4220794948 cites W2295452771 @default.
• W4220794948 cites W2460587805 @default.
• W4220794948 cites W2517999713 @default.
• W4220794948 cites W2766773217 @default.
• W4220794948 cites W2767318757 @default.
• W4220794948 cites W2802604216 @default.
• W4220794948 cites W2810174954 @default.
• W4220794948 cites W2839641827 @default.
• W4220794948 cites W2888373299 @default.
• W4220794948 cites W2891696188 @default.
• W4220794948 cites W2901659912 @default.
• W4220794948 cites W2913083861 @default.
• W4220794948 cites W2949297378 @default.
• W4220794948 cites W2949352374 @default.
• W4220794948 cites W2951062006 @default.
• W4220794948 cites W2951480227 @default.
• W4220794948 cites W2952978770 @default.
• W4220794948 cites W3011565822 @default.
• W4220794948 cites W3012079654 @default.
• W4220794948 cites W3081022498 @default.
• W4220794948 cites W3083581329 @default.
• W4220794948 cites W3131376036 @default.
• W4220794948 cites W3161704324 @default.
• W4220794948 cites W4232591682 @default.
• W4220794948 cites W4235125648 @default.
• W4220794948 cites W4251304755 @default.
• W4220794948 cites W91426214 @default.
• W4220794948 doi "https://doi.org/10.1093/genetics/iyac008" @default.
• W4220794948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35100421" @default.
• W4220794948 hasPublicationYear "2022" @default.
• W4220794948 type Work @default.
• W4220794948 citedByCount "8" @default.
• W4220794948 countsByYear W42207949482022 @default.
• W4220794948 countsByYear W42207949482023 @default.
• W4220794948 crossrefType "journal-article" @default.
• W4220794948 hasAuthorship W4220794948A5004699011 @default.
• W4220794948 hasAuthorship W4220794948A5018561698 @default.
• W4220794948 hasAuthorship W4220794948A5018787679 @default.
• W4220794948 hasAuthorship W4220794948A5018816923 @default.
• W4220794948 hasBestOaLocation W42207949481 @default.
• W4220794948 hasConcept C104317684 @default.
• W4220794948 hasConcept C119857082 @default.
• W4220794948 hasConcept C137848329 @default.
• W4220794948 hasConcept C141231307 @default.
• W4220794948 hasConcept C144024400 @default.
• W4220794948 hasConcept C149923435 @default.
• W4220794948 hasConcept C154945302 @default.
• W4220794948 hasConcept C169733012 @default.
• W4220794948 hasConcept C2776214188 @default.
• W4220794948 hasConcept C2776620128 @default.
• W4220794948 hasConcept C2908647359 @default.
• W4220794948 hasConcept C3641667 @default.
• W4220794948 hasConcept C41008148 @default.
• W4220794948 hasConcept C54355233 @default.
• W4220794948 hasConcept C68873052 @default.
• W4220794948 hasConcept C7386963 @default.
• W4220794948 hasConcept C75268714 @default.
• W4220794948 hasConcept C78458016 @default.
• W4220794948 hasConcept C80990810 @default.
• W4220794948 hasConcept C81917197 @default.
• W4220794948 hasConcept C86803240 @default.
• W4220794948 hasConceptScore W4220794948C104317684 @default.
• W4220794948 hasConceptScore W4220794948C119857082 @default.
• W4220794948 hasConceptScore W4220794948C137848329 @default.
• W4220794948 hasConceptScore W4220794948C141231307 @default.
• W4220794948 hasConceptScore W4220794948C144024400 @default.
• W4220794948 hasConceptScore W4220794948C149923435 @default.
• W4220794948 hasConceptScore W4220794948C154945302 @default.
• W4220794948 hasConceptScore W4220794948C169733012 @default.
• W4220794948 hasConceptScore W4220794948C2776214188 @default.
• W4220794948 hasConceptScore W4220794948C2776620128 @default.
• W4220794948 hasConceptScore W4220794948C2908647359 @default.

• next