FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4220795767> ?p ?o ?g. }

• W4220795767 abstract "Doxorubicin (DOX)-based chemotherapy induces cardiotoxicity, which is considered the main bottleneck for its clinical application. In this study, we investigated the potential benefit of LCZ696, an angiotensin receptor-neprilysin inhibitor against DOX-induced cardiotoxicity in rats and H9c2 cells and determined whether the mechanism underlying any such effects involves its antioxidant activity. Male Sprague-Dawley rats were randomly separated into four groups, each consisting of 15 rats (DOX (1.5 mg/kg/day intraperitoneally for 10 days followed by non-treatment for 8 days); DOX + valsartan (31 mg/kg/day by gavage from day 1 to day 18); DOX + LCZ696 (68 mg/kg/day by gavage from day 1 to day 18); and control (saline intraperitoneally for 10 days). DOX-induced elevation of cardiac troponin T levels on day 18 was significantly reduced by LCZ696, but not valsartan. The DOX-induced increase in myocardial reactive oxygen species (ROS) levels determined using dihydroethidium was significantly ameliorated by LCZ696, but not valsartan, and was accompanied by the suppression of DOX-induced increase in p47phox. LCZ696 recovered the DOX-induced decrease in phosphorylation of adenosine monophosphate-activated protein kinase and increased the ratio of Bax and Bcl-2. In H9c2 cardiomyocytes, LCZ696 reduced DOX-induced mitochondrial ROS generation and improved cell viability more than valsartan. Our findings indicated that LCZ696 ameliorated DOX-induced cardiotoxicity in rat hearts in vivo and in vitro, possibly by mediating a decrease in oxidative stress." @default.
• W4220795767 created "2022-04-03" @default.
• W4220795767 creator A5013902236 @default.
• W4220795767 creator A5038761025 @default.
• W4220795767 creator A5043379112 @default.
• W4220795767 creator A5043888002 @default.
• W4220795767 creator A5044544721 @default.
• W4220795767 creator A5050052282 @default.
• W4220795767 creator A5054946828 @default.
• W4220795767 creator A5059830493 @default.
• W4220795767 creator A5069940779 @default.
• W4220795767 date "2022-03-23" @default.
• W4220795767 modified "2023-09-26" @default.
• W4220795767 title "LCZ696 ameliorates doxorubicin-induced cardiomyocyte toxicity in rats" @default.
• W4220795767 cites W1969046837 @default.
• W4220795767 cites W1976801946 @default.
• W4220795767 cites W1997643551 @default.
• W4220795767 cites W2032130572 @default.
• W4220795767 cites W2032255547 @default.
• W4220795767 cites W2061497413 @default.
• W4220795767 cites W2066075295 @default.
• W4220795767 cites W2084304742 @default.
• W4220795767 cites W2101425508 @default.
• W4220795767 cites W2109775164 @default.
• W4220795767 cites W2113698123 @default.
• W4220795767 cites W2116655536 @default.
• W4220795767 cites W2117205119 @default.
• W4220795767 cites W2133475821 @default.
• W4220795767 cites W2133931932 @default.
• W4220795767 cites W2161641464 @default.
• W4220795767 cites W2164047272 @default.
• W4220795767 cites W2166727347 @default.
• W4220795767 cites W2219104789 @default.
• W4220795767 cites W2224556300 @default.
• W4220795767 cites W2508734629 @default.
• W4220795767 cites W2602877283 @default.
• W4220795767 cites W2626025616 @default.
• W4220795767 cites W2752615679 @default.
• W4220795767 cites W2782989835 @default.
• W4220795767 cites W2793811377 @default.
• W4220795767 cites W2800400752 @default.
• W4220795767 cites W2800855528 @default.
• W4220795767 cites W2913659775 @default.
• W4220795767 cites W2913819594 @default.
• W4220795767 cites W2936272451 @default.
• W4220795767 cites W2946052904 @default.
• W4220795767 cites W2955313267 @default.
• W4220795767 cites W2980685854 @default.
• W4220795767 cites W2990867293 @default.
• W4220795767 cites W3013813924 @default.
• W4220795767 cites W3018618577 @default.
• W4220795767 cites W3036482718 @default.
• W4220795767 cites W3083836943 @default.
• W4220795767 cites W3087335547 @default.
• W4220795767 cites W3087594112 @default.
• W4220795767 cites W3087881743 @default.
• W4220795767 cites W3111514975 @default.
• W4220795767 cites W3119310840 @default.
• W4220795767 cites W4229825080 @default.
• W4220795767 cites W4244656864 @default.
• W4220795767 doi "https://doi.org/10.1038/s41598-022-09094-z" @default.
• W4220795767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35322164" @default.
• W4220795767 hasPublicationYear "2022" @default.
• W4220795767 type Work @default.
• W4220795767 citedByCount "8" @default.
• W4220795767 countsByYear W42207957672022 @default.
• W4220795767 countsByYear W42207957672023 @default.
• W4220795767 crossrefType "journal-article" @default.
• W4220795767 hasAuthorship W4220795767A5013902236 @default.
• W4220795767 hasAuthorship W4220795767A5038761025 @default.
• W4220795767 hasAuthorship W4220795767A5043379112 @default.
• W4220795767 hasAuthorship W4220795767A5043888002 @default.
• W4220795767 hasAuthorship W4220795767A5044544721 @default.
• W4220795767 hasAuthorship W4220795767A5050052282 @default.
• W4220795767 hasAuthorship W4220795767A5054946828 @default.
• W4220795767 hasAuthorship W4220795767A5059830493 @default.
• W4220795767 hasAuthorship W4220795767A5069940779 @default.
• W4220795767 hasBestOaLocation W42207957671 @default.
• W4220795767 hasConcept C126322002 @default.
• W4220795767 hasConcept C134018914 @default.
• W4220795767 hasConcept C184235292 @default.
• W4220795767 hasConcept C185592680 @default.
• W4220795767 hasConcept C195794163 @default.
• W4220795767 hasConcept C2776108454 @default.
• W4220795767 hasConcept C2776151105 @default.
• W4220795767 hasConcept C2776694085 @default.
• W4220795767 hasConcept C2777387769 @default.
• W4220795767 hasConcept C2778233292 @default.
• W4220795767 hasConcept C2779676291 @default.
• W4220795767 hasConcept C2781303535 @default.
• W4220795767 hasConcept C29730261 @default.
• W4220795767 hasConcept C541997718 @default.
• W4220795767 hasConcept C55493867 @default.
• W4220795767 hasConcept C71924100 @default.
• W4220795767 hasConcept C84393581 @default.
• W4220795767 hasConcept C98274493 @default.
• W4220795767 hasConceptScore W4220795767C126322002 @default.
• W4220795767 hasConceptScore W4220795767C134018914 @default.
• W4220795767 hasConceptScore W4220795767C184235292 @default.
• W4220795767 hasConceptScore W4220795767C185592680 @default.

• next