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• W4220796518 endingPage "106170" @default.
• W4220796518 startingPage "106170" @default.
• W4220796518 abstract "The purpose of this work is to explore the preparation of nanofibrous orally dispersible films (ODFs) by needleless electrospinning from the active pharmaceutical ingredient (API) Tadalafil using particles suspended in a solution of polymers and other excipients. The prepared films were characterized by a combination of scanning electron microscopy, mechanical tests, measurements of the disintegration time and dissolution characteristic, X-ray diffraction, and differential scanning calorimetry. Furthermore, we investigated the impact of lamination pressures in the range of 0 to 5 bars combined with films at various relative humidity values on the mechanical properties of the ODF. An increase in lamination pressure resulted in higher Young's modulus values, with the maximum value observed for a sample laminated at a pressure of 5 bar and the maximum stress and strain of the prepared ODF at a lamination pressure of 1.2 bar. Moreover, there was a significant increase in the disintegration time with increase in lamination pressure. The disintegration time ranged from 0.35 s for non-laminated samples to 12 s for samples laminated at a pressure of 5 bar. On the contrary, the lamination pressure did not reveal to have any impact on the dissolution kinetics. These results confirmed that the lamination pressure can improve the processability of ODFs without affecting the API dissolution kinetics." @default.
• W4220796518 created "2022-04-03" @default.
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• W4220796518 date "2022-06-01" @default.
• W4220796518 modified "2023-10-04" @default.
• W4220796518 title "The impact of the lamination pressure on the properties of electrospinned nanofibrous films" @default.
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• W4220796518 doi "https://doi.org/10.1016/j.ejps.2022.106170" @default.
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